{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:35:27Z","timestamp":1758962127012},"reference-count":57,"publisher":"Hindawi Limited","issue":"7","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1111\/and.12699","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T02:53:48Z","timestamp":1475204028000},"page":"e12699","source":"Crossref","is-referenced-by-count":10,"title":["Protective effects of vitamin E on sodium arsenite-induced toxicity, testicular measurements and histopathological studies of testes in Teddy goat bucks"],"prefix":"10.1155","volume":"49","author":[{"given":"M.","family":"Zubair","sequence":"first","affiliation":[{"name":"Department of Theriogenology; University of Agriculture; Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Theriogenology; University of Agriculture; Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Saleemi","sequence":"additional","affiliation":[{"name":"Department of Pathology; University of Agriculture; Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. T.","family":"Gul","sequence":"additional","affiliation":[{"name":"Department of Pathology; University of Agriculture; Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Theriogenology; University of Agriculture; Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Umar","sequence":"additional","affiliation":[{"name":"Department of Theriogenology; University of Agriculture; Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"10.1111\/and.12699-BIB0001|and12699-cit-0001","doi-asserted-by":"crossref","first-page":"287","DOI":"10.29309\/TPMJ\/2008.15.02.2760","article-title":"Arsenic induced microscopic changes in rat testis","volume":"15","author":"Ahmad","year":"2008","journal-title":"Professional Medical Journal"},{"key":"10.1111\/and.12699-BIB0002|and12699-cit-0002","first-page":"130","article-title":"Factors affecting body size and horn length in small holder rams","volume":"1","author":"Akpa","year":"2006","journal-title":"Savannah Journal of Agriculture"},{"key":"10.1111\/and.12699-BIB0003|and12699-cit-0003","first-page":"7","article-title":"Relationships between body and scrotal measurements, and semen characteristics in Yankasa ram","volume":"4","author":"Akpa","year":"2012","journal-title":"Continental Journal of Animal and Veterinary Research"},{"key":"10.1111\/and.12699-BIB0004|and12699-cit-0004","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/j.1939-4640.1981.tb00595.x","article-title":"A critical review of methods for evaluation of spermatogenesis from seminal characteristics","volume":"2","author":"Aman","year":"1982","journal-title":"Journal of Andrology"},{"key":"10.1111\/and.12699-BIB0005|and12699-cit-0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.9734\/BBJ\/2015\/12325","article-title":"Effect of arsenic (As) on the spermatogenesis of Black Bengal goat (Capra hircus) reared at the arsenic prone area of Mymensingh District in Bangladesh","volume":"5","author":"Awal","year":"2015","journal-title":"British Biotechnology Journal"},{"key":"10.1111\/and.12699-BIB0006|and12699-cit-0006","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0093-691X(96)00245-2","article-title":"Testicular shape and its relationship in sperm production of matured Holstein bulls","volume":"46","author":"Bailey","year":"1996","journal-title":"Theriogenology"},{"key":"10.1111\/and.12699-BIB0007|and12699-cit-0007","first-page":"125","volume-title":"Theory and Practice of Histological Techniques","author":"Bancroft","year":"2007","edition":"6"},{"key":"10.1111\/and.12699-BIB0008|and12699-cit-0008","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1615\/JEnvironPatholToxicolOncol.v26.i1.40","article-title":"Investigation on the genotoxic effects of long-term administration of sodium arsenite in bone marrow and testicular cell in vivo using comet assay","volume":"26","author":"Biswas","year":"2006","journal-title":"Journal of Environmental Pathology, Toxicology and Oncology"},{"key":"10.1111\/and.12699-BIB0009|and12699-cit-0009","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ecoenv.2012.11.023","article-title":"Simultaneously evaluate the toxic levels of fluoride and arsenic species in underground water of Tharparkar and possible contaminant sources: A multivariate study","volume":"89","author":"Brahman","year":"2013","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"10.1111\/and.12699-BIB0102|and12699-cit-0102","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/bmj.305.6854.609","article-title":"Evidence for decreasing quality of semen during past 50 years","volume":"305","author":"Carlsen","year":"1992","journal-title":"BMJ"},{"key":"10.1111\/and.12699-BIB0010|and12699-cit-0010","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.taap.2006.11.009","article-title":"Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis","volume":"218","author":"Chang","year":"2007","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1111\/and.12699-BIB0011|and12699-cit-0011","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1289\/ehp.8457219","article-title":"Effect of ethylene glycol monoethyl ether on various parameters of testicular function in the F344 rats","volume":"57","author":"Chapin","year":"1984","journal-title":"Environ Health Perspectives"},{"key":"10.1111\/and.12699-BIB0012|and12699-cit-0012","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0531-5565(01)00118-8","article-title":"Age-related increase in mitochondrial superoxide generation in the testosterone producing cells of Brown Norway rat testes: Relationship to reduced steroidogenic function","volume":"36","author":"Chen","year":"2001","journal-title":"Experimental Gerontology"},{"key":"10.1111\/and.12699-BIB0013|and12699-cit-0013","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.exger.2005.06.004","article-title":"Vitamin E, aging and Leydig cell steroidogenesis","volume":"40","author":"Chen","year":"2005","journal-title":"Experimental Gerontology"},{"key":"10.1111\/and.12699-BIB0014|and12699-cit-0014","first-page":"331","article-title":"Dependence of testicular germ cells on hormones: A quantitative study in hypophysectomized testosterone treated rats","volume":"82","author":"Chowdhury","year":"1979","journal-title":"Journal of Andrology"},{"key":"10.1111\/and.12699-BIB0015|and12699-cit-0015","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1439-0272.1999.tb02853.x","article-title":"The effects of p-nonylphenol on the fertility potential of male rats after gestational, lactational and direct exposure","volume":"31","author":"Jager","year":"1998","journal-title":"Andrologia"},{"key":"10.1111\/and.12699-BIB0103|and12699-cit-0103","first-page":"878","article-title":"Effect of selenium and \/or vitamin E administration on semen sharacteristics, plasma testosterone level and some immunogenetic constituents in seminal plasma proteins of Baladi Bucks","volume":"12","author":"El-Sheshtawy","year":"2014","journal-title":"Global Veterinaria"},{"key":"10.1111\/and.12699-BIB0016|and12699-cit-0016","first-page":"2","article-title":"Protective effect of thymoquinone against arsenic-induced testicular toxicity in rats","volume":"8","author":"Fouad","year":"2014","journal-title":"International Journal of Medical Health Pharmaceutical and Biomedical Engineering"},{"key":"10.1111\/and.12699-BIB0017|and12699-cit-0017","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00244-012-9810-3","article-title":"Arsenic exposure to dairy cows in Bangladesh","volume":"64","author":"Ghosh","year":"2013","journal-title":"Archives of Environmental Contamination and Toxicology"},{"key":"10.1111\/and.12699-BIB0018|and12699-cit-0018","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0278-6915(84)90092-9","article-title":"Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells","volume":"22","author":"Gray","year":"1984","journal-title":"Food and Chemical Toxicology"},{"key":"10.1111\/and.12699-BIB0019|and12699-cit-0019","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0378-4274(98)00115-5","article-title":"Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico","volume":"99","author":"Hern\u00e1ndez-Zavala","year":"1998","journal-title":"Toxicology Letters"},{"key":"10.1111\/and.12699-BIB0020|and12699-cit-0020","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0891-5849(89)90163-9","article-title":"Steroid and xenobiotic effects on the adrenal cortex: Mediation by oxidative and other mechanisms","volume":"6","author":"Hornsby","year":"1989","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1111\/and.12699-BIB0021|and12699-cit-0021","doi-asserted-by":"crossref","first-page":"883","DOI":"10.9734\/BBJ\/2014\/9939","article-title":"Assessment of toxic metals in dairy milk and animal feed in Peshawar, Pakistan","volume":"4","author":"Iftikhar","year":"2014","journal-title":"British Biotechnology Journal"},{"key":"10.1111\/and.12699-BIB0022|and12699-cit-0022","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1477-7827-4-9","article-title":"Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: Possible an estrogenic mode of action","volume":"4","author":"Jana","year":"2006","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.1111\/and.12699-BIB0023|and12699-cit-0023","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1210\/endo.142.9.8375","article-title":"Caspase-3 and caspase- activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced intratesticular testosterone","volume":"142","author":"Kim","year":"2001","journal-title":"Endocrinology"},{"key":"10.1111\/and.12699-BIB0101|and12699-cit-0101","first-page":"137","article-title":"Naturally occurring arsenic in groundwaters of the midwestern United States","volume":"18","author":"Korte","year":"1991","journal-title":"Environmental Geology"},{"key":"10.1111\/and.12699-BIB0025|and12699-cit-0025","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.2527\/1997.75112994x","article-title":"Effects of dietary selenium and vitamin E on boar performance and tissue responses, semen quality, and subsequent fertilization rates in mature gilts","volume":"75","author":"Marin-Guzman","year":"1997","journal-title":"Journal of Animal Science"},{"key":"10.1111\/and.12699-BIB0026|and12699-cit-0026","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1530\/acta.0.1020470","article-title":"Vitamin E prolongs survival and function of porcine Leydig cells in culture","volume":"102","author":"Mather","year":"1983","journal-title":"Acta Endocrinologica (Copenh.)"},{"key":"10.1111\/and.12699-BIB0027|and12699-cit-0027","first-page":"428","article-title":"Status of arsenic in certain feeds, water and animals in Bareilly and Mukteswar region","volume":"30","author":"Mohanta","year":"2013","journal-title":"Indian Journal of Animal Nutrition"},{"key":"10.1111\/and.12699-BIB0028|and12699-cit-0028","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1642-431X(12)60084-9","article-title":"Effect of vitamin E on sperm number and testis histopathology of sodium arsenite-treated rats","volume":"2","author":"Momeni","year":"2012","journal-title":"Reproductive Biology"},{"key":"10.1111\/and.12699-BIB0029|and12699-cit-0029","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1439-0272.2000.00391.x","article-title":"Sertoli\u00a0cells as a target for reproductive hazards","volume":"32","author":"Monsees","year":"2000","journal-title":"Andrologia"},{"key":"10.1111\/and.12699-BIB0030|and12699-cit-0030","first-page":"39","article-title":"Effect of zingiber officinale (Ginger) on sodium arsenite- induced reproductive toxicity in male rats","volume":"13","author":"Morakinyo","year":"2010","journal-title":"African Journal of Biomedical Sciences"},{"key":"10.1111\/and.12699-BIB0031|and12699-cit-0031","first-page":"193","volume-title":"Goat Production","author":"Morand-Fehr","year":"1981"},{"key":"10.1111\/and.12699-BIB0032|and12699-cit-0032","first-page":"73","article-title":"Studies on arsenic toxicity in male rat gonads and its protection by high dietary protein supplementation","volume":"2","author":"Mukherjee","year":"2009","journal-title":"Al Ameen Journal of Medical Sciences"},{"key":"10.1111\/and.12699-BIB0033|and12699-cit-0033","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/26387","article-title":"Arsenic poisoning of Bangladesh ground water","volume":"395","author":"Nickson","year":"1998","journal-title":"Nature"},{"key":"10.1111\/and.12699-BIB0034|and12699-cit-0034","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4067\/S0717-95022008000100020","article-title":"Sperm morphological studies of West African Dwarf bucks treated with pumpkin plant (Cucurbita pepo)","volume":"26","author":"Oyeyemi","year":"2008","journal-title":"International Journal of Morphology"},{"key":"10.1111\/and.12699-BIB0035|and12699-cit-0035","unstructured":"Pakistan Council of Research in Water Resources(PCRWR) 2002 \u201cWater quality status in Pakistan, 1st report 2001-2002,\u201d"},{"key":"10.1111\/and.12699-BIB0036|and12699-cit-0036","first-page":"365","volume-title":"The Sertoli Cell","author":"Pelliniemi","year":"1993"},{"key":"10.1111\/and.12699-BIB0037|and12699-cit-0037","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1210\/endo.137.1.8536600","article-title":"Induction of lipid peroxidation during steroidogenesis in the rat testis","volume":"137","author":"Peltola","year":"1996","journal-title":"Endocrinology"},{"key":"10.1111\/and.12699-BIB0038|and12699-cit-0038","first-page":"289","article-title":"Morphological changes of the intestinal villi in chickens fed the dietary charcoal powder including wood vinegar compounds","volume":"38","author":"Samanya","year":"2001","journal-title":"Asian Journal of Andrology"},{"key":"10.1111\/and.12699-BIB0039|and12699-cit-0039","first-page":"27","article-title":"Effects of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats","volume":"5","author":"Sarkar","year":"2003","journal-title":"Asian Journal of Andrology"},{"key":"10.1111\/and.12699-BIB0040|and12699-cit-0040","first-page":"266","article-title":"Diagnosis of avain paramyxovirus type-1 infection in chicken by immunoflourescence technique","volume":"13","author":"Shahzad","year":"2011","journal-title":"International Journal of Agriculture and Biology"},{"key":"10.1111\/and.12699-BIB0041|and12699-cit-0041","first-page":"348","article-title":"Morphometrical study of seminiferous tubules of mice using arsenic and Chlorophytum borivilianum","volume":"2","author":"Sharma","year":"2011","journal-title":"Pharmacologyonline"},{"key":"10.1111\/and.12699-BIB0042|and12699-cit-0042","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1677\/joe.0.1170019","article-title":"Re-evaluation of the intratesticular level of testosterone required for quantitative maintenance of spermatogenesis in the rat","volume":"117","author":"Sharpe","year":"1988","journal-title":"Journal of Endocrinology"},{"key":"10.1111\/and.12699-BIB0043|and12699-cit-0043","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1289\/ehp.951031136","article-title":"Gestational and lactational exposures of rat to xenoestrogen results in reduced testicular size and sperm Production","volume":"103","author":"Sharpe","year":"1995","journal-title":"Environmental Health Perspectives"},{"key":"10.1111\/and.12699-BIB0044|and12699-cit-0044","first-page":"172","article-title":"Testosterone and spermatogenesis: Identification of stage dependent, androgen- regulated proteins secreted by adult rat seminiferous tubules","volume":"13","author":"Sharpe","year":"1992","journal-title":"Journal of Andrology"},{"key":"10.1111\/and.12699-BIB0045|and12699-cit-0045","volume-title":"Statistical Methods","author":"Snedecor","year":"1967"},{"key":"10.1111\/and.12699-BIB0046|and12699-cit-0046","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/aja.2009.29","article-title":"Stereological study of the effects of Vitamin E on testis structure in rats treated with para-nonylphenol","volume":"11","author":"Soleimani","year":"2009","journal-title":"Asian Journal of Andrology"},{"key":"10.1111\/and.12699-BIB0048|and12699-cit-0048","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pestbp.2006.06.010","article-title":"Acute, subacute and subchronic administration of methyl parathion-induced testicular damage in male rats and protective role of vitamins C and E","volume":"87","author":"Uzunhisarcikli","year":"2007","journal-title":"Pesticide Biology and Physiology"},{"key":"10.1111\/and.12699-BIB0049|and12699-cit-0049","doi-asserted-by":"crossref","first-page":"128","DOI":"10.5455\/javar.2015.b61","article-title":"Chronic natural arsenic exposure affecting histoarchitecture of gonads in Black Bengal goats (Capra aegagrushircus)","volume":"2","author":"Wares","year":"2015","journal-title":"Journal of Advanced Veterinary and Animal Research"},{"key":"10.1111\/and.12699-BIB0050|and12699-cit-0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3329\/jbau.v11i1.18220","article-title":"Environmental health hazard of arsenic on epididymis and ductus deferens in male Black Bengal goats","volume":"11","author":"Wares","year":"2013","journal-title":"Journal of Bangladesh Agricultural University"},{"key":"10.1111\/and.12699-BIB0051|and12699-cit-0051","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/BF00770599","article-title":"Arsenic contamination in surface drainage and groundwater in part of the southeast Asian tin belt, Nakhon Si Thammarat Province, southern Thailand","volume":"27","author":"Williams","year":"1996","journal-title":"Environmental Geology"},{"key":"10.1111\/and.12699-BIB0052|and12699-cit-0052","first-page":"217","volume-title":"Trace Elements in Human Nutrition and Health","author":"World Health Organization","year":"1996"},{"key":"10.1111\/and.12699-BIB0053|and12699-cit-0053","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/humrep\/15.7.1543","article-title":"Significance of human testicular mast cells and their subtypes in male infertility","volume":"15","author":"Yamanaka","year":"2000","journal-title":"Human Reproduction"},{"key":"10.1111\/and.12699-BIB0054|and12699-cit-0054","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.anireprosci.2009.08.004","article-title":"Effect of vitamin E supplementation on semen quality and the testicular cell membranal and mitochondrial antioxidant abilities in Aohan fine-wool sheep","volume":"118","author":"Yue","year":"2010","journal-title":"Animal Reproduction Science"},{"key":"10.1111\/and.12699-BIB0055|and12699-cit-0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.anireprosci.2008.05.076","article-title":"Effect of vitamin E supplementation on development of reproductive organs in Boer goat","volume":"113","author":"Zhu","year":"2009","journal-title":"Animal Reproduction Science"},{"key":"10.1111\/and.12699-BIB0056|and12699-cit-0056","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.mam.2007.05.004","article-title":"Vitamin E: An overview of major research directions","volume":"28","author":"Zingg","year":"2007","journal-title":"Molecular Aspects of Medicine"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12699","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12699\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:38:29Z","timestamp":1671539909000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,29]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,9]]}},"URL":"https:\/\/doi.org\/10.1111\/and.12699","archive":["Portico"],"relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9,29]]}}}