{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:48:33Z","timestamp":1785548913565,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973003"],"award-info":[{"award-number":["30973003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901993"],"award-info":[{"award-number":["30901993"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Administration of TCM of Jiangsu province","award":["LZ11093"],"award-info":[{"award-number":["LZ11093"]}]},{"name":"Young Medical Talents of Jiangsu Province","award":["QNRC2016530"],"award-info":[{"award-number":["QNRC2016530"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1111\/and.12922","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T10:27:27Z","timestamp":1512469647000},"page":"e12922","source":"Crossref","is-referenced-by-count":18,"title":["Establishment of experimental autoimmune prostatitis model by T<sub>2<\/sub>peptide in aluminium hydroxide adjuvant"],"prefix":"10.1155","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-1724","authenticated-orcid":false,"given":"L.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy; School of Basic Medicine and Clinical Pharmacy; China Pharmaceutical University; Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. U.","family":"Ihsan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy; School of Basic Medicine and Clinical Pharmacy; China Pharmaceutical University; Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy; School of Basic Medicine and Clinical Pharmacy; China Pharmaceutical University; Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy; School of Basic Medicine and Clinical Pharmacy; China Pharmaceutical University; Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy; School of Basic Medicine and Clinical Pharmacy; China Pharmaceutical University; Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"issue":"5","key":"10.1111\/and.12922-BIB0001|and12922-cit-0001","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0090-4295(98)00390-2","article-title":"Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis\/chronic pelvic pain syndrome","volume":"52","author":"Alexander","year":"1998","journal-title":"Urology"},{"issue":"1","key":"10.1111\/and.12922-BIB0002|and12922-cit-0002","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0264-410X(95)80009-3","article-title":"Contribution of electrostatic and hydrophobic interactions to the adsorption of proteins by aluminium-containing adjuvants","volume":"13","author":"Al-Shakhshir","year":"1995","journal-title":"Vaccine"},{"issue":"6","key":"10.1111\/and.12922-BIB0003|and12922-cit-0003","first-page":"R415","article-title":"A novel murine model of chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) induced by immunization with a spermine binding protein (p25) peptide","volume":"304","author":"Altuntas","year":"2013","journal-title":"American Journal of Physiology: Regulatory, Integrative and Comparative Physiology"},{"key":"10.1111\/and.12922-BIB0004|and12922-cit-0004","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annual Review of Immunology"},{"issue":"1","key":"10.1111\/and.12922-BIB0005|and12922-cit-0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00042307-200301000-00005","article-title":"Chronic prostatitis","volume":"13","author":"Batstone","year":"2003","journal-title":"Current Opinion in Urology"},{"issue":"1","key":"10.1111\/and.12922-BIB0006|and12922-cit-0006","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/MOU.0b013e32835abd4a","article-title":"Correlation between benign prostatic hyperplasia and inflammation","volume":"23","author":"Bostanci","year":"2013","journal-title":"Current Opinion in Urology"},{"issue":"7","key":"10.1111\/and.12922-BIB0007|and12922-cit-0007","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.4049\/jimmunol.159.7.3113","article-title":"Induction of tissue-specific autoimmune prostatitis with prostatic acid phosphatase immunization: Implications for immunotherapy of prostate cancer","volume":"159","author":"Fong","year":"1997","journal-title":"The Journal of Immunology"},{"issue":"2","key":"10.1111\/and.12922-BIB0008|and12922-cit-0008","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1439-0272.1983.tb00129.x","article-title":"C-reactive protein in semen and serum of men with chronic prostatitis","volume":"15","author":"Girgis","year":"1983","journal-title":"Andrologia"},{"issue":"3","key":"10.1111\/and.12922-BIB0009|and12922-cit-0009","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jcf.2010.01.005","article-title":"Sputum and serum calprotectin are useful biomarkers during CF exacerbation","volume":"9","author":"Gray","year":"2010","journal-title":"Journal of Cystic Fibrosis"},{"issue":"5","key":"10.1111\/and.12922-BIB0010|and12922-cit-0010","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1586\/14760584.6.5.685","article-title":"Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation","volume":"6","author":"Hem","year":"2007","journal-title":"Expert Review of Vaccines"},{"key":"10.1111\/and.12922-BIB0011|and12922-cit-0011","article-title":"The role of inflammatory cytokines and ERK1\/2 signaling in chronic prostatitis\/chronic pelvic pain syndrome with related mental health disorders","volume":"6","author":"Hu","year":"2016","journal-title":"Scientific Reports"},{"issue":"11-12","key":"10.1111\/and.12922-BIB0012|and12922-cit-0012","doi-asserted-by":"crossref","first-page":"403","DOI":"10.5489\/cuaj.2179","article-title":"Psychosocial mechanisms of the pain and quality of life relationship for chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS)","volume":"8","author":"Krsmanovic","year":"2014","journal-title":"Canadian Urological Association Journal"},{"issue":"3","key":"10.1111\/and.12922-BIB0013|and12922-cit-0013","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000052453","article-title":"Immunocytological analysis of leukocyte subpopulations in urine specimens before and after prostatic massage","volume":"39","author":"Ludwig","year":"2001","journal-title":"European Urology"},{"issue":"3","key":"10.1111\/and.12922-BIB0014|and12922-cit-0014","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12672-010-0063-1","article-title":"Testosterone regulates tight junction proteins and influences prostatic autoimmune responses","volume":"2","author":"Meng","year":"2011","journal-title":"Hormones and Cancer"},{"issue":"1","key":"10.1111\/and.12922-BIB0015|and12922-cit-0015","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0022-5347(05)67497-6","article-title":"IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis","volume":"164","author":"Nadler","year":"2000","journal-title":"Journal of Urology"},{"key":"10.1111\/and.12922-BIB0016|and12922-cit-0016","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0022-5347(17)41924-0","article-title":"The role of androgens and estrogens in the pathogenesis of experimental nonbacterial prostatitis","volume":"140","author":"Naslund","year":"1988","journal-title":"The Journal of Urology"},{"issue":"12","key":"10.1111\/and.12922-BIB0017|and12922-cit-0017","doi-asserted-by":"crossref","first-page":"8504","DOI":"10.4049\/jimmunol.177.12.8504","article-title":"Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol","volume":"177","author":"Penna","year":"2006","journal-title":"The Journal of Immunology"},{"issue":"5","key":"10.1111\/and.12922-BIB0018|and12922-cit-0018","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1586\/eci.09.37","article-title":"Prostate autoimmunity: From experimental models to clinical counterparts","volume":"5","author":"Penna","year":"2009","journal-title":"Expert Review of Clinical Immunology"},{"issue":"5 Suppl","key":"10.1111\/and.12922-BIB0020|and12922-cit-0020","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1016\/j.juro.2008.03.139","article-title":"Mechanisms in prostatitis\/chronic pelvic pain syndrome","volume":"179","author":"Pontari","year":"2008","journal-title":"Journal of Urology"},{"key":"10.1111\/and.12922-BIB0021|and12922-cit-0021","first-page":"1389","article-title":"Prostate Extract With Aluminum Hydroxide Injection as a Novel Animal Model for Chronic Prostatitis\/Chronic Pelvic Pain Syndrome","volume":"80","author":"Qi","year":"2012","journal-title":"Journal of Urology"},{"issue":"2","key":"10.1111\/and.12922-BIB0022|and12922-cit-0022","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/clim.2002.5281","article-title":"Prostatein or steroid binding protein (PSBP) induces experimental autoimmune prostatitis (EAP) in NOD mice","volume":"105","author":"Rivero","year":"2002","journal-title":"Clinical Immunology"},{"issue":"11","key":"10.1111\/and.12922-BIB0023|and12922-cit-0023","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/aje\/kwp085","article-title":"Associations between C-reactive protein and benign prostatic hyperplasia\/lower urinary tract symptom outcomes in a population-based cohort","volume":"169","author":"St Sauver","year":"2009","journal-title":"American Journal of Epidemiology"},{"issue":"3","key":"10.1111\/and.12922-BIB0024|and12922-cit-0024","first-page":"365","article-title":"Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens","volume":"82","author":"Taguchi","year":"1994","journal-title":"Immunology"},{"issue":"7","key":"10.1111\/and.12922-BIB0025|and12922-cit-0025","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1464-410X.2012.11088.x","article-title":"Alpha-blockers, antibiotics and anti-inflammatories have a role in the management of chronic prostatitis\/chronic pelvic pain syndrome","volume":"110","author":"Thakkinstian","year":"2012","journal-title":"BJU International"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12922\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T17:28:15Z","timestamp":1693330095000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"URL":"https:\/\/doi.org\/10.1111\/and.12922","archive":["Portico"],"relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12,4]]}}}