{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:53:39Z","timestamp":1789588419299,"version":"build-2803163510"},"reference-count":111,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003033","name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n Productiva","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006449","name":"Fundaci\u00f3n Alberto J. Roemmers","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006449","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010413","name":"Fundaci\u00f3n Ren\u00e9 Bar\u00f3n","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010413","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundaci\u00f3n Williams"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1111\/and.13034","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:48:42Z","timestamp":1525826922000},"page":"e13034","source":"Crossref","is-referenced-by-count":60,"title":["Ageing and inflammation in the male reproductive tract"],"prefix":"10.1155","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-6245","authenticated-orcid":false,"given":"M. B.","family":"Frungieri","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental, CONICET; Ciudad de Buenos Aires Argentina"},{"name":"C\u00e1tedra de Qu\u00edmica; Ciclo B\u00e1sico Com\u00fan; Universidad de Buenos Aires; Ciudad de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Calandra","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental, CONICET; Ciudad de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bartke","sequence":"additional","affiliation":[{"name":"Geriatrics Research; Department of Internal Medicine; School of Medicine; Southern Illinois University; Springfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Matzkin","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental, CONICET; Ciudad de Buenos Aires Argentina"},{"name":"Departamento de Bioqu\u00edmica Humana; Facultad de Medicina; Universidad de Buenos Aires; Ciudad de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"10.1111\/and.13034-BIB0001|and13034-cit-0001","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1093\/humrep\/det112","article-title":"Paracetamol, aspirin and indomethacin display endocrine disrupting properties in the adult human testis in vitro","volume":"28","author":"Albert","year":"2013","journal-title":"Human Reproduction"},{"key":"10.1111\/and.13034-BIB0002|and13034-cit-0002","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tem.2009.11.005","article-title":"Metabolic reprogramming, caloric restriction and aging","volume":"21","author":"Anderson","year":"2010","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1111\/and.13034-BIB0003|and13034-cit-0003","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2605.2010.01112.x","article-title":"Zaditen (Ketotifen), as\u00a0mast cell\u00a0blocker, improves sperm quality, chromatin integrity and pregnancy rate after varicocelectomy","volume":"34","author":"Azadi","year":"2011","journal-title":"International Journal of Andrology"},{"key":"10.1111\/and.13034-BIB0004|and13034-cit-0004","first-page":"123","article-title":"Impact of inflammation on male reproductive tract","volume":"16","author":"Azenabor","year":"2015","journal-title":"Journal of Reproduction & Infertility"},{"key":"10.1111\/and.13034-BIB0005|and13034-cit-0005","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2265.1976.tb01964.x","article-title":"Changes in the pituitary-testicular system with age","volume":"5","author":"Baker","year":"1976","journal-title":"Clinical Endocrinology - Oxford"},{"key":"10.1111\/and.13034-BIB0006|and13034-cit-0006","first-page":"13","article-title":"Apoptotic changes in aging testis","volume":"21","author":"Barbutska","year":"2015","journal-title":"Acta Morphologica et Anthropologica"},{"key":"10.1111\/and.13034-BIB0007|and13034-cit-0007","doi-asserted-by":"crossref","first-page":"B199","DOI":"10.1093\/gerona\/54.5.B199","article-title":"Effect of aging and dietary restriction on rat testicular germ cell apoptosis","volume":"54","author":"Barnes","year":"1999","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1111\/and.13034-BIB0008|and13034-cit-0008","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1874609808666150422123355","article-title":"Early life events can shape\u00a0aging\u00a0and longevity","volume":"8","author":"Bartke","year":"2015","journal-title":"Current Aging Science"},{"key":"10.1111\/and.13034-BIB0009|and13034-cit-0009","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ghir.2016.02.002","article-title":"The somatotropic axis and\u00a0aging: Benefits of endocrine defects","volume":"27","author":"Bartke","year":"2016","journal-title":"Growth Hormone & IGF Research"},{"key":"10.1111\/and.13034-BIB0010|and13034-cit-0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2046-2395-2-8","article-title":"Understanding how we age: Insights into inflammaging","volume":"2","author":"Baylis","year":"2013","journal-title":"Longevity & Healthspan"},{"key":"10.1111\/and.13034-BIB0011|and13034-cit-0011","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1530\/JOE-10-0402","article-title":"Cardiac extrinsic apoptotic pathway is silent in young but activated in elder mice overexpressing bovine GH: Interplay with the intrinsic pathway","volume":"210","author":"Bogazzi","year":"2011","journal-title":"Journal of Endocrinology"},{"key":"10.1111\/and.13034-BIB0012|and13034-cit-0012","first-page":"72","article-title":"Dynamics of proliferation and apoptosis in the human\u00a0bulbourethral glands\u00a0in the process of\u00a0aging","volume":"129","author":"Boronikhina","year":"2006","journal-title":"Morfologiia"},{"key":"10.1111\/and.13034-BIB0013|and13034-cit-0013","first-page":"63","article-title":"Age-related changes in glycoprotein composition in human\u00a0bulbourethral glands","volume":"131","author":"Boronikhina","year":"2007","journal-title":"Morfologiia"},{"key":"10.1111\/and.13034-BIB0014|and13034-cit-0014","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1017\/CBO9780511736254.006","volume-title":"An introduction to male reproductive medicine","author":"Brannigan","year":"2011"},{"key":"10.1111\/and.13034-BIB0015|and13034-cit-0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1385\/ENDO:11:1:41","article-title":"Antioxidative mechanisms and plasma growth hormone levels: Potential relationship in the aging process","volume":"11","author":"Brown-Borg","year":"1999","journal-title":"Endocrine"},{"key":"10.1111\/and.13034-BIB0016|and13034-cit-0016","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.mad.2003.07.001","article-title":"Growth hormone administration to long-living dwarf mice alters multiple components of the antioxidative defense system","volume":"124","author":"Brown-Borg","year":"2003","journal-title":"Mechanisms of Ageing and Development"},{"key":"10.1111\/and.13034-BIB0017|and13034-cit-0017","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00062752-200105000-00001","article-title":"Aging and proinflammatory cytokines","volume":"8","author":"Bruunsgaard","year":"2001","journal-title":"Current Opinion in Hematology"},{"key":"10.1111\/and.13034-BIB0018|and13034-cit-0018","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jsbmb.2003.10.007","article-title":"Aging alters the functional expression of enzymatic and non-enzymatic antioxidant defense systems in testicular rat Leydig cells","volume":"88","author":"Cao","year":"2004","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"key":"10.1111\/and.13034-BIB0019|and13034-cit-0019","first-page":"233","article-title":"Bovine seminal vesiculitis. A review and update","volume":"13","author":"Cavalieri","year":"1997","journal-title":"Veterinary Clinics: Food Animal Practice"},{"key":"10.1111\/and.13034-BIB0020|and13034-cit-0020","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1210\/endo.140.3.6557","article-title":"Pituitary and testicular function in growth hormone receptor gene knockout mice","volume":"140","author":"Chandrashekar","year":"1999","journal-title":"Endocrinology"},{"key":"10.1111\/and.13034-BIB0021|and13034-cit-0021","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0531-5565(01)00118-8","article-title":"Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: Relationship to reduced steroidogenic function?","volume":"36","author":"Chen","year":"2001","journal-title":"Experimental Gerontology"},{"key":"10.1111\/and.13034-BIB0022|and13034-cit-0022","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mce.2009.01.023","article-title":"Leydig cells: From stem cells to aging","volume":"306","author":"Chen","year":"2009","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1111\/and.13034-BIB0023|and13034-cit-0023","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.exger.2005.06.004","article-title":"Vitamin E, aging and Leydig cell steroidogenesis","volume":"40","author":"Chen","year":"2005","journal-title":"Experimental Gerontology"},{"key":"10.1111\/and.13034-BIB0024|and13034-cit-0024","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-59745-453-7_7","volume-title":"The Leydig cell in health and disease","author":"Chen","year":"2007"},{"key":"10.1111\/and.13034-BIB0025|and13034-cit-0025","doi-asserted-by":"crossref","first-page":"14877","DOI":"10.1073\/pnas.96.26.14877","article-title":"Long-term\u00a0suppression of Leydig cell steroidogenesis prevents Leydig cell aging","volume":"96","author":"Chen","year":"1999","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1111\/and.13034-BIB0026|and13034-cit-0026","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1158\/0008-5472.CAN-04-1216","article-title":"Protein profiling of microdissected prostate tissue links growth differentiation factor 15 to prostate carcinogenesis","volume":"64","author":"Cheung","year":"2004","journal-title":"Cancer Research"},{"key":"10.1111\/and.13034-BIB0027|and13034-cit-0027","first-page":"147","article-title":"Role\u00a0of\u00a0inflammation\u00a0in\u00a0benign prostatic hyperplasia","volume":"13","author":"Chughtai","year":"2011","journal-title":"Reviews in Urology"},{"key":"10.1111\/and.13034-BIB0028|and13034-cit-0028","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1365-2605.2005.00499.x","article-title":"A neglected gland: A review of Cowper's gland","volume":"28","author":"Chughtai","year":"2005","journal-title":"International Journal of Andrology"},{"key":"10.1111\/and.13034-BIB0029|and13034-cit-0029","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.urology.2007.11.041","article-title":"Age-related increase of reactive oxygen species in neat semen in healthy fertile men","volume":"71","author":"Cocuzza","year":"2008","journal-title":"Urology"},{"key":"10.1111\/and.13034-BIB0030|and13034-cit-0030","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1210\/en.2003-0374","article-title":"Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span","volume":"144","author":"Coschigano","year":"2003","journal-title":"Endocrinology"},{"key":"10.1111\/and.13034-BIB0031|and13034-cit-0031","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ghir.2010.06.001","article-title":"Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice","volume":"20","author":"Coschigano","year":"2010","journal-title":"Growth Hormone & IGF Research"},{"key":"10.1111\/and.13034-BIB0032|and13034-cit-0032","doi-asserted-by":"crossref","first-page":"H1882","DOI":"10.1152\/ajpheart.412.2008","article-title":"Endothelial function and vascular oxidative stress in long-lived GH\/IGF-deficient Ames dwarf mice","volume":"295","author":"Csiszar","year":"2008","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1111\/and.13034-BIB0033|and13034-cit-0033","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1095\/biolreprod62.1.103","article-title":"Ovarian follicle apoptosis in bovine growth hormone transgenic mice","volume":"62","author":"Danilovich","year":"2000","journal-title":"Biology of Reproduction"},{"key":"10.1111\/and.13034-BIB0034|and13034-cit-0034","first-page":"e979114","article-title":"Interpreting histopathology in the epididymis","volume":"8","author":"De Grava Kempinas","year":"2015","journal-title":"Spermatogenesis"},{"key":"10.1111\/and.13034-BIB0035|and13034-cit-0035","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.2174\/138161209789058110","article-title":"An update of the oxidation-inflammation theory of aging: The involvement of the immune system in oxi-inflamm-aging","volume":"15","author":"De la Fuente","year":"2009","journal-title":"Current Pharmaceutical Design"},{"key":"10.1111\/and.13034-BIB0036|and13034-cit-0036","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrc2090","article-title":"Inflammation in prostate carcinogenesis","volume":"7","author":"De Marzo","year":"2007","journal-title":"Nature Reviews Cancer"},{"key":"10.1111\/and.13034-BIB0037|and13034-cit-0037","doi-asserted-by":"crossref","first-page":"E74","DOI":"10.5489\/cuaj.10116","article-title":"Vasitis: Clinical and ultrasound confusion with inguinal hernia clarified by computed tomography","volume":"5","author":"Eddy","year":"2011","journal-title":"Canadian Urological Association Journal"},{"key":"10.1111\/and.13034-BIB0038|and13034-cit-0038","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1210\/jcem.87.2.8201","article-title":"Age\u00a0trends\u00a0in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study","volume":"87","author":"Feldman","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1111\/and.13034-BIB0039|and13034-cit-0039","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cellsig.2004.09.017","article-title":"The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1\/2)","volume":"17","author":"Frungieri","year":"2005","journal-title":"Cellular Signalling"},{"key":"10.1111\/and.13034-BIB0040|and13034-cit-0040","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0015-0282(02)03206-5","article-title":"Number, distribution pattern, and identification of macrophages in the testes of infertile men","volume":"78","author":"Frungieri","year":"2002","journal-title":"Fertility and Sterility"},{"key":"10.1111\/and.13034-BIB0041|and13034-cit-0041","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1210\/en.2006-0090","article-title":"Cyclooxygenase-2 and prostaglandin F2 alpha in Syrian hamster Leydig cells: inhibitory role on luteinizing hormone\/human chorionic gonadotropin-stimulated testosterone production","volume":"147","author":"Frungieri","year":"2006","journal-title":"Endocrinology"},{"key":"10.1111\/and.13034-BIB0042|and13034-cit-0042","doi-asserted-by":"crossref","first-page":"15072","DOI":"10.1073\/pnas.232422999","article-title":"Proliferative action of mast cell tryptase is mediated by PAR2, COX2, prostaglandins and PPAR\u03b3: Possible relevance to human fibrotic disorders","volume":"99","author":"Frungieri","year":"2002","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1111\/and.13034-BIB0043|and13034-cit-0043","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1258\/ebm.2010.010202","article-title":"Decreased expression level of apoptosis related genes and\/or proteins in skeletal muscles, but not in hearts, of growth hormone receptor knockout mice","volume":"236","author":"Gesing","year":"2011","journal-title":"Experimental Biology and Medicine"},{"key":"10.1111\/and.13034-BIB0044|and13034-cit-0044","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jmor.10287","article-title":"Ultrastructure of testicular macrophages in aging mice","volume":"263","author":"Giannessi","year":"2005","journal-title":"Journal of Morphology"},{"key":"10.1111\/and.13034-BIB0045|and13034-cit-0045","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1477-7827-8-148","article-title":"Expression of the TGF-beta1 system in human testicular pathologies","volume":"8","author":"Gonzalez","year":"2010","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.1111\/and.13034-BIB0046|and13034-cit-0046","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0378-4320(97)00019-5","article-title":"Impaired sperm characteristics in postpubertal growth hormone deficient dwarf (dw\/dw) rats","volume":"49","author":"Gravance","year":"1997","journal-title":"Animal Reproduction Science"},{"key":"10.1111\/and.13034-BIB0047|and13034-cit-0047","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/jemt.20704","article-title":"Cytokines and chemokines in testicular inflammation: A brief review","volume":"72","author":"Guazzone","year":"2009","journal-title":"Microscopy Research and Technique"},{"key":"10.1111\/and.13034-BIB0048|and13034-cit-0048","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/(SICI)1097-0045(20000101)42:1<73::AID-PROS9>3.0.CO;2-G","article-title":"Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma","volume":"42","author":"Gupta","year":"2000","journal-title":"Prostate"},{"key":"10.1111\/and.13034-BIB0049|and13034-cit-0049","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0165-0378(02)00020-7","article-title":"Testicular macrophage modulation of\u00a0Leydig cell\u00a0steroidogenesis","volume":"57","author":"Hales","year":"2002","journal-title":"Journal of Reproductive Immunology"},{"key":"10.1111\/and.13034-BIB0050|and13034-cit-0050","first-page":"117","volume-title":"The Leydig cell in health and disease","author":"Hales","year":"2007"},{"key":"10.1111\/and.13034-BIB0051|and13034-cit-0051","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1210\/jcem.86.2.7219","article-title":"Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging","volume":"86","author":"Harman","year":"2001","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1111\/and.13034-BIB0052|and13034-cit-0052","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/014850101316901307","article-title":"The treatment with tranilast, a\u00a0mast cell\u00a0blocker, for idiopathic oligozoospermia","volume":"47","author":"Hibi","year":"2001","journal-title":"Archives of Andrology"},{"key":"10.1111\/and.13034-BIB0053|and13034-cit-0053","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jcp.41.4.419","article-title":"Vasitis nodosa and associated clinical findings","volume":"41","author":"Hirschowitz","year":"1988","journal-title":"Journal of Clinical Pathology"},{"key":"10.1111\/and.13034-BIB0054|and13034-cit-0054","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH633>3.0.CO;2-X","article-title":"Immunohistochemical localization of interleukin-6 and its receptor in benign, premalignant and malignant prostate tissue","volume":"191","author":"Hobisch","year":"2000","journal-title":"The Journal of Pathology"},{"key":"10.1111\/and.13034-BIB0055|and13034-cit-0055","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1258\/ebm.2010.009335","article-title":"Anti-inflammatory activity of soy and tea in prostate cancer prevention","volume":"235","author":"Hsu","year":"2010","journal-title":"Experimental Biology and Medicine"},{"key":"10.1111\/and.13034-BIB0056|and13034-cit-0056","first-page":"267","article-title":"Seminal\u00a0vesiculitis","volume":"24","author":"Hull","year":"2008","journal-title":"Veterinary Clinics: Food Animal Practice"},{"key":"10.1111\/and.13034-BIB0057|and13034-cit-0057","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.autrev.2010.09.026","article-title":"Testicular autoimmunity","volume":"10","author":"Jacobo","year":"2011","journal-title":"Autoimmunity Reviews"},{"key":"10.1111\/and.13034-BIB0058|and13034-cit-0058","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5489\/cuaj.1129","article-title":"Nonsteroidal anti-inflammatory drugs and prostate cancer: A systematic review of the literature and meta-analysis","volume":"3","author":"Jafari","year":"2009","journal-title":"Canadian Urological Association Journal"},{"key":"10.1111\/and.13034-BIB0059|and13034-cit-0059","first-page":"451","article-title":"Inflammation in aging: Cause, effect, or both?","volume":"13","author":"Jenny","year":"2012","journal-title":"Discovery Medicine"},{"key":"10.1111\/and.13034-BIB0060|and13034-cit-0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/9780470696019.ch6","volume-title":"Male infertility: A guide for the clinician","author":"Jequier","year":"2000"},{"key":"10.1111\/and.13034-BIB0061|and13034-cit-0061","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s11255-013-0610-0","article-title":"Quantitative histological analysis and ultrastructure of the aging human testis","volume":"6","author":"Jiang","year":"2014","journal-title":"International Urology and Nephrology"},{"key":"10.1111\/and.13034-BIB0062|and13034-cit-0062","first-page":"35","article-title":"Evaluation of the human testis and its age-related dysfunction","volume":"302","author":"Johnson","year":"1989","journal-title":"Progress in Clinical and Biological Research"},{"key":"10.1111\/and.13034-BIB0063|and13034-cit-0063","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/00365590802223585","article-title":"Chronic abacterial\u00a0prostatitis: Living with a troublesome disease affecting many aspects of life","volume":"42","author":"Jonsson","year":"2008","journal-title":"Scandinavian Journal of Urology and Nephrology"},{"key":"10.1111\/and.13034-BIB0064|and13034-cit-0064","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1365-2605.2012.01281.x","article-title":"Evidence for an adaptation in ROS scavenging systems in human testicular peritubular cells from infertility patients","volume":"35","author":"Kampfer","year":"2012","journal-title":"International Journal of Andrology"},{"key":"10.1111\/and.13034-BIB0065|and13034-cit-0065","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/j.1939-4640.2003.tb02661.x","article-title":"Balance of apoptosis and proliferation of germ cells related to spermatogenesis in aged men","volume":"24","author":"Kimura","year":"2003","journal-title":"Journal of Andrology"},{"key":"10.1111\/and.13034-BIB0066|and13034-cit-0066","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0090-4295(00)00674-9","article-title":"Expression of cyclooxygenase-1 and cyclooxygenase-2 in the human prostate","volume":"56","author":"Kirschenbaum","year":"2000","journal-title":"Urology"},{"key":"10.1111\/and.13034-BIB0067|and13034-cit-0067","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.exger.2004.01.009","article-title":"Inflammatory mediators in the elderly","volume":"39","author":"Krabbe","year":"2004","journal-title":"Experimental Gerontology"},{"key":"10.1111\/and.13034-BIB0068|and13034-cit-0068","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1439-0272.2007.00822.x","article-title":"Male accessory gland infection","volume":"40","author":"Krause","year":"2008","journal-title":"Andrologia"},{"key":"10.1111\/and.13034-BIB0069|and13034-cit-0069","doi-asserted-by":"crossref","first-page":"E715","DOI":"10.1073\/pnas.1715035115","article-title":"Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism","volume":"115","author":"Kristensen","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1111\/and.13034-BIB0070|and13034-cit-0070","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nrendo.2016.55","article-title":"Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects","volume":"12","author":"Kristensen","year":"2016","journal-title":"Nature Reviews Endocrinology"},{"key":"10.1111\/and.13034-BIB0071|and13034-cit-0071","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.2174\/1381612822666161019150241","article-title":"Redox regulation of fertility in\u00a0aging\u00a0male and the role of antioxidants: A savior or stressor","volume":"23","author":"Leisegang","year":"2017","journal-title":"Current Pharmaceutical Design"},{"key":"10.1111\/and.13034-BIB0072|and13034-cit-0072","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1210\/en.2005-0654","article-title":"Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis","volume":"147","author":"Li","year":"2006","journal-title":"Endocrinology"},{"key":"10.1111\/and.13034-BIB0073|and13034-cit-0073","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0531-5565(02)00125-0","article-title":"Effect of aging on macrophage function","volume":"37","author":"Lloberas","year":"2002","journal-title":"Experimental Gerontology"},{"key":"10.1111\/and.13034-BIB0074|and13034-cit-0074","first-page":"116","article-title":"The relationship between testosterone and molecular markers of inflammation in older men","volume":"28","author":"Maggio","year":"2005","journal-title":"Journal of Endocrinological Investigation"},{"key":"10.1111\/and.13034-BIB0075|and13034-cit-0075","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.mad.2005.03.012","article-title":"Overview of caloric restriction and ageing","volume":"126","author":"Masoro","year":"2005","journal-title":"Mechanisms of Ageing and Development"},{"key":"10.1111\/and.13034-BIB0076|and13034-cit-0076","doi-asserted-by":"crossref","first-page":"17293","DOI":"10.3402\/pba.v2i0.17293","article-title":"Growth hormone, inflammation and aging","volume":"2","author":"Masternak","year":"2012","journal-title":"Pathobiology of Aging & Age-Related Diseases"},{"key":"10.1111\/and.13034-BIB0077|and13034-cit-0077","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.fertnstert.2010.01.039","article-title":"Cyclooxygenase-2 in testes of infertile men: Evidence for the induction of prostaglandin synthesis by interleukin-1\u03b2","volume":"94","author":"Matzkin","year":"2010","journal-title":"Fertility and Sterility"},{"key":"10.1111\/and.13034-BIB0078|and13034-cit-0078","doi-asserted-by":"crossref","first-page":"95","DOI":"10.18632\/aging.100875","article-title":"Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes","volume":"8","author":"Matzkin","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"10.1111\/and.13034-BIB0079|and13034-cit-0079","first-page":"723","article-title":"Epididymitis: An Overview","volume":"94","author":"McConaghy","year":"2016","journal-title":"American Family Physician"},{"key":"10.1111\/and.13034-BIB0080|and13034-cit-0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0015-0282(00)00626-9","article-title":"Human testicular mast cells contain tryptase: Increased mast cell number and altered distribution in the testes of infertile men","volume":"74","author":"Meineke","year":"2000","journal-title":"Fertility and Sterility"},{"key":"10.1111\/and.13034-BIB0081|and13034-cit-0081","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/REP-16-0025","article-title":"Resveratrol\u00a0improves reproductive parameters of adult rats varicocelized in peripuberty","volume":"152","author":"Mendes","year":"2016","journal-title":"Reproduction"},{"key":"10.1111\/and.13034-BIB0082|and13034-cit-0082","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrurol.2015.276","article-title":"An update on the diagnosis and management of\u00a0ejaculatory\u00a0duct\u00a0obstruction","volume":"13","author":"Modgil","year":"2016","journal-title":"Nature Reviews Urology"},{"key":"10.1111\/and.13034-BIB0083|and13034-cit-0083","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/j.1939-4640.1998.tb02039.x","article-title":"The effects of\u00a0aging\u00a0on the expression of glutathione S-transferases in the testis and\u00a0epididymis of the Brown Norway rat","volume":"19","author":"Mueller","year":"1998","journal-title":"Journal of Andrology"},{"key":"10.1111\/and.13034-BIB0084|and13034-cit-0084","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2174\/1568010054526322","article-title":"Inflammatory cells and oxygen radicals","volume":"4","author":"Nagata","year":"2005","journal-title":"Current Drug Targets: Inflammation & Allergy"},{"key":"10.1111\/and.13034-BIB0085|and13034-cit-0085","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/sj.bjc.6600869","article-title":"Quantitative analysis of macrophage inhibitory cytokine-1 (MIC-1) gene expression in human prostatic tissues","volume":"88","author":"Nakamura","year":"2003","journal-title":"British Journal of Cancer"},{"key":"10.1111\/and.13034-BIB0086|and13034-cit-0086","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.lpm.2017.05.006","article-title":"Testicular tumors of adrenogenital syndrome: From physiopathology to\u00a0therapy","volume":"46","author":"Naouar","year":"2017","journal-title":"Presse Medicale (Paris, France: 1983)"},{"key":"10.1111\/and.13034-BIB0087|and13034-cit-0087","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0301-2115(95)02539-1","article-title":"Effect of low dose continuous corticosteroid therapy in men with antisperm antibodies on spermatozoal quality and conception rate","volume":"69","author":"Omu","year":"1996","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"10.1111\/and.13034-BIB0088|and13034-cit-0088","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/jemt.1060190209","article-title":"Ultrastructure of the aging human testis","volume":"19","author":"Paniagua","year":"1991","journal-title":"Microscopy Research and Technique"},{"key":"10.1111\/and.13034-BIB0089|and13034-cit-0089","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1474-9728.2004.00102.x","article-title":"Innate immunity in aging: Impact on macrophage function","volume":"3","author":"Plowden","year":"2004","journal-title":"Aging Cell"},{"key":"10.1111\/and.13034-BIB0090|and13034-cit-0090","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: How are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1111\/and.13034-BIB0091|and13034-cit-0091","first-page":"30045","article-title":"Prostaglandin E2 (PGE2) is a testicular peritubular cell-derived factor involved in human testicular homeostasis","author":"Rey-Ares","year":"2018","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1111\/and.13034-BIB0092|and13034-cit-0092","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/pros.21027","article-title":"Inflammation in benign prostatic hyperplasia: A 282 patients\u2019 immunohistochemical analysis","volume":"69","author":"Robert","year":"2009","journal-title":"Prostate"},{"key":"10.1111\/and.13034-BIB0093|and13034-cit-0093","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.2047-2927.2014.00207.x","article-title":"Melatonin in testes of infertile men: Evidence for anti-proliferative and anti-oxidant effects on local macrophage and mast cell populations","volume":"2","author":"Rossi","year":"2014","journal-title":"Andrology"},{"key":"10.1111\/and.13034-BIB0094|and13034-cit-0094","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.mce.2016.06.021","article-title":"Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression\/activity in TM4 Sertoli cells","volume":"434","author":"Rossi","year":"2016","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1111\/and.13034-BIB0095|and13034-cit-0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00345-011-0726-8","article-title":"Influence of urogenital infections and inflammation on semen quality and male fertility","volume":"30","author":"Rusz","year":"2012","journal-title":"World Journal of Urology"},{"key":"10.1111\/and.13034-BIB0096|and13034-cit-0096","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1210\/en.2009-1325","article-title":"15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: Implications for human male fertility","volume":"151","author":"Schell","year":"2010","journal-title":"Endocrinology"},{"key":"10.1111\/and.13034-BIB0097|and13034-cit-0097","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1439-0272.1986.tb01831.x","article-title":"The use of ketotifen, a mast cell blocker, for treatment of oligo- and asthenozoospermia","volume":"18","author":"Schill","year":"1986","journal-title":"Andrologia"},{"key":"10.1111\/and.13034-BIB0098|and13034-cit-0098","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1096\/fasebj.14.1.145","article-title":"Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL\/6NNIA mice","volume":"14","author":"Sell","year":"2000","journal-title":"The FASEB Journal"},{"key":"10.1111\/and.13034-BIB0099|and13034-cit-0099","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.lpm.2013.12.003","article-title":"Aging of the human testis","volume":"43","author":"Sibert","year":"2014","journal-title":"Presse Medicale (Paris, France: 1983)"},{"key":"10.1111\/and.13034-BIB0100|and13034-cit-0100","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1210\/endo.133.6.8243310","article-title":"The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells","volume":"133","author":"Stocco","year":"1993","journal-title":"Endocrinology"},{"key":"10.1111\/and.13034-BIB0101|and13034-cit-0101","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1210\/endo.142.12.8526","article-title":"Gene expression in Brown Norway rat Leydig cells: Effects of age and of age-related germ cell loss","volume":"142","author":"Syntin","year":"2001","journal-title":"Endocrinology"},{"key":"10.1111\/and.13034-BIB0102|and13034-cit-0102","first-page":"583","article-title":"Epididymitis and orchitis: An overview","volume":"79","author":"Trojian","year":"2009","journal-title":"American Family Physician"},{"key":"10.1111\/and.13034-BIB0103|and13034-cit-0103","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1055\/s-2007-980021","article-title":"Elucidation of autoimmune disease mechanism based on testicular and ovarian autoimmune disease models","volume":"27","author":"Tung","year":"1995","journal-title":"Hormone and Metabolic Research"},{"key":"10.1111\/and.13034-BIB0104|and13034-cit-0104","first-page":"A323","article-title":"Male urethritis in general practice. STDs more common at a younger age","volume":"153","author":"Vriend","year":"2009","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"key":"10.1111\/and.13034-BIB0105|and13034-cit-0105","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1210\/en.2005-0298","article-title":"Cyclooxygenase-2 regulation of the age-related decline in testosterone biosynthesis","volume":"146","author":"Wang","year":"2005","journal-title":"Endocrinology"},{"key":"10.1111\/and.13034-BIB0106|and13034-cit-0106","doi-asserted-by":"crossref","first-page":"8426874","DOI":"10.1155\/2016\/8426874","article-title":"An update on inflamm-aging: Mechanisms, prevention, and treatment","volume":"2016","author":"Xia","year":"2016","journal-title":"Journal of Immunology Research"},{"key":"10.1111\/and.13034-BIB0107|and13034-cit-0107","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4111\/icu.2017.58.3.205","article-title":"What are the differences between older and younger patients with epididymitis?","volume":"58","author":"Yamamichi","year":"2017","journal-title":"Investigative and Clinical Urology"},{"key":"10.1111\/and.13034-BIB0108|and13034-cit-0108","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0015-0282(16)57992-8","article-title":"New treatment of idiopathic severe oligozoospermia with mast cell blocker: Results of a single-blind study","volume":"64","author":"Yamamoto","year":"1995","journal-title":"Fertility and Sterility"},{"key":"10.1111\/and.13034-BIB0109|and13034-cit-0109","doi-asserted-by":"crossref","first-page":"913","DOI":"10.7863\/ultra.33.5.913","article-title":"Sonographic\u00a0findings\u00a0of tuberculous\u00a0vasitis","volume":"33","author":"Yang","year":"2014","journal-title":"Journal of Ultrasound in Medicine"},{"key":"10.1111\/and.13034-BIB0110|and13034-cit-0110","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.exger.2013.05.063","article-title":"Effects of moderate exercise over different phases on age-related physiological dysfunction in testes of SAMP8 mice","volume":"48","author":"Zhao","year":"2013","journal-title":"Experimental Gerontology"},{"key":"10.1111\/and.13034-BIB0111|and13034-cit-0111","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1095\/biolreprod63.4.977","article-title":"Regulation of leydig cell steroidogenic function during aging","volume":"63","author":"Zirkin","year":"2000","journal-title":"Biology of Reproduction"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.13034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.13034\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T12:38:30Z","timestamp":1720269510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.13034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":111,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1111\/and.13034","archive":["Portico"],"relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5,8]]}}}