{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:50:00Z","timestamp":1772776200240,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1111\/and.13066","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T08:40:10Z","timestamp":1528879210000},"page":"e13066","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of seminal granulysin in infertile men with varicocele"],"prefix":"10.1155","volume":"50","author":[{"given":"Nancy W.","family":"Mikhael","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology & Andrology; Faculty of Medicine; Benha University; Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa M.","family":"El-Refaie","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology & Andrology; Faculty of Medicine; Benha University; Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jehan H.","family":"Sabry","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology; Faculty of Medicine; Benha University; Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9579-1727","authenticated-orcid":false,"given":"Essam M.","family":"Akl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology & Andrology; Faculty of Medicine; Benha University; Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal Y.","family":"Habashy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology & Andrology; Faculty of Medicine; Benha University; Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-0662","authenticated-orcid":false,"given":"Taymour","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Andrology, Sexology & STIs; Faculty of Medicine; Cairo University; Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"10.1111\/and.13066-BIB0001|and13066-cit-0001","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/1008-682X.172640","article-title":"Epidemiology of varicocele","volume":"18","author":"Alsaikhan","year":"2016","journal-title":"Asian Journal of Andrology"},{"key":"10.1111\/and.13066-BIB0002|and13066-cit-0002","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0022-2836(02)01234-2","article-title":"Granulysin crystal structure and a structure-derived lytic mechanism","volume":"325","author":"Anderson","year":"2003","journal-title":"Journal of Molecular Biology"},{"key":"10.1111\/and.13066-BIB0003|and13066-cit-0003","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bcp.2013.11.004","article-title":"Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors","volume":"87","author":"Aporta","year":"2014","journal-title":"Biochemical Pharmacology"},{"key":"10.1111\/and.13066-BIB0004|and13066-cit-0004","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/cmi.2009.3","article-title":"Cell death mechanisms induced by cytotoxic lymphocytes","volume":"6","author":"Ch\u00e1vez-Gal\u00e1n","year":"2009","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1111\/and.13066-BIB0005|and13066-cit-0005","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.blre.2016.04.005","article-title":"Autophagy as a target for hematological malignancy therapy","volume":"30","author":"Dong","year":"2016","journal-title":"Blood Reviews"},{"key":"10.1111\/and.13066-BIB0006|and13066-cit-0006","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0015-0282(16)37684-1","article-title":"Varicocele size and results of varicocelectomy in selected subfertile men with varicocele","volume":"21","author":"Dubin","year":"1970","journal-title":"Fertility and Sterility"},{"key":"10.1111\/and.13066-BIB0007|and13066-cit-0007","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/0970-1591.78428","article-title":"Varicocele-induced infertility: Newer insights into its pathophysiology","volume":"27","author":"Eisenberg","year":"2011","journal-title":"Indian Journal of Urology"},{"key":"10.1111\/and.13066-BIB0008|and13066-cit-0008","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1439-0272.2008.00894.x","article-title":"Programmed cell death in varicocele-bearing testes","volume":"41","author":"Hassan","year":"2009","journal-title":"Andrologia"},{"key":"10.1111\/and.13066-BIB0009|and13066-cit-0009","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/jcem.83.1.4485","article-title":"Spontaneous germ cell apoptosis in humans: Evidence for ethnic differences in the susceptibility of germ cells to programmed cell death","volume":"83","author":"Hikim","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1111\/and.13066-BIB0010|and13066-cit-0010","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrurol.2017.98","article-title":"Varicocele and male infertility","volume":"14","author":"Jensen","year":"2017","journal-title":"Nature Reviews. Urology"},{"key":"10.1111\/and.13066-BIB0011|and13066-cit-0011","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1464-410X.2005.05807.x","article-title":"The role of apoptosis in the pathogenesis of varicocele","volume":"96","author":"Ku","year":"2005","journal-title":"BJU International"},{"key":"10.1111\/and.13066-BIB0012|and13066-cit-0012","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00345-008-0367-8","article-title":"Involved intrinsic apoptotic pathway of testicular tissues in varicocele-induced rats","volume":"27","author":"Lee","year":"2009","journal-title":"World Journal of Urology"},{"key":"10.1111\/and.13066-BIB0013|and13066-cit-0013","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2217\/imt.15.56","article-title":"Death ligands and granulysin: Mechanisms of tumor cell death induction and therapeutic opportunities","volume":"7","author":"Martinez-Lostao","year":"2015","journal-title":"Immunotherapy"},{"key":"10.1111\/and.13066-BIB0014|and13066-cit-0014","doi-asserted-by":"crossref","first-page":"597495","DOI":"10.1155\/2012\/597495","article-title":"A critical appraisal on the role of varicocele in male infertility","volume":"2012","author":"Miyaoka","year":"2012","journal-title":"Advances in Urology"},{"key":"10.1111\/and.13066-BIB0015|and13066-cit-0015","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1439-0272.2010.01111.x","article-title":"Seminal plasma reactive oxygen species-antioxidants relationship with varicocele grade","volume":"44","author":"Mostafa","year":"2012","journal-title":"Andrologia"},{"key":"10.1111\/and.13066-BIB0016|and13066-cit-0016","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1365-2605.2001.00296.x","article-title":"Varicocelectomy reduces reactive oxygen species levels and increases antioxidant activity of seminal plasma from infertile men with varicocele","volume":"24","author":"Mostafa","year":"2001","journal-title":"International Journal of Andrology"},{"key":"10.1111\/and.13066-BIB0017|and13066-cit-0017","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/andr.12462","article-title":"Seminal SIRT1 expression in infertile oligoasthenoteratozoospermic men with varicocele","volume":"6","author":"Mostafa","year":"2018","journal-title":"Andrology"},{"key":"10.1111\/and.13066-BIB0018|and13066-cit-0018","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.urology.2014.05.016","article-title":"Seminal BAX and BCL2 gene and protein expressions in infertile men with varicocele","volume":"84","author":"Mostafa","year":"2014","journal-title":"Urology"},{"key":"10.1111\/and.13066-BIB0019|and13066-cit-0019","doi-asserted-by":"crossref","first-page":"4302754","DOI":"10.1155\/2016\/4302754","article-title":"Seminal miRNA relationship with apoptotic markers and oxidative stress in infertile men with varicocele","volume":"2016","author":"Mostafa","year":"2016","journal-title":"BioMed Research International"},{"key":"10.1111\/and.13066-BIB0020|and13066-cit-0020","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2353\/ajpath.2008.071169","article-title":"Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion","volume":"173","author":"Nakashima","year":"2008","journal-title":"American Journal of Pathology"},{"key":"10.1111\/and.13066-BIB0021|and13066-cit-0021","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.4049\/jimmunol.171.5.2556","article-title":"Intracellular mediators of granulysin-induced cell death","volume":"171","author":"Okada","year":"2003","journal-title":"The Journal of Immunology"},{"key":"10.1111\/and.13066-BIB0022|and13066-cit-0022","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.4049\/jimmunol.167.3.1222","article-title":"A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis","volume":"167","author":"Pardo","year":"2001","journal-title":"The Journal of Immunology"},{"key":"10.1111\/and.13066-BIB0023|and13066-cit-0023","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/1008-682X.167716","article-title":"Major regulatory mechanisms involved in sperm motility","volume":"19","author":"Pereira","year":"2017","journal-title":"Asian Journal of Andrology"},{"key":"10.1111\/and.13066-BIB0024|and13066-cit-0024","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.urology.2007.08.019","article-title":"Relationship between testicular volume and varicocele in patients with infertility","volume":"71","author":"Sakamoto","year":"2008","journal-title":"Urology"},{"key":"10.1111\/and.13066-BIB0025|and13066-cit-0025","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10815-017-0931-5","article-title":"Genetics and epigenetics of varicocele pathophysiology: An overview","volume":"34","author":"Santana","year":"2017","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"10.1111\/and.13066-BIB0026|and13066-cit-0026","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11934-017-0713-8","article-title":"The role of varicocele in male factor subfertility","volume":"18","author":"Sedaghatpour","year":"2017","journal-title":"Current Urology Reports"},{"key":"10.1111\/and.13066-BIB0027|and13066-cit-0027","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.molimm.2004.07.034","article-title":"Activation of NK cell cytotoxicity","volume":"42","author":"Smyth","year":"2005","journal-title":"Molecular Immunology"},{"key":"10.1111\/and.13066-BIB0028|and13066-cit-0028","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.juro.2011.06.061","article-title":"Effect of smoking status on seminal parameters and apoptotic markers in infertile men","volume":"186","author":"Tawadrous","year":"2011","journal-title":"Journal of Urology"},{"key":"10.1111\/and.13066-BIB0029|and13066-cit-0029","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jri.2009.05.009","article-title":"Male germ cell development: Turning on the apoptotic pathways","volume":"83","author":"Tripathi","year":"2009","journal-title":"Journal of Reproductive Immunology"},{"key":"10.1111\/and.13066-BIB0200|and13066-cit-0200","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000314226","article-title":"Effect of varicocele grade and age on seminal parameters","volume":"85","author":"Vivas-Acevedo","year":"2010","journal-title":"Urologia Internationalis"},{"key":"10.1111\/and.13066-BIB0030|and13066-cit-0030","volume-title":"WHO laboratory manual for the examination and processing of human semen","author":"World Health Organization","year":"2010","edition":"5"},{"key":"10.1111\/and.13066-BIB0031|and13066-cit-0031","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/andr.12445","article-title":"Effect of varicocelectomy and\/or mast cells stabilizer on sperm DNA fragmentation in infertile patients with varicocele","volume":"6","author":"Zaazaa","year":"2018","journal-title":"Andrology"},{"key":"10.1111\/and.13066-BIB0032|and13066-cit-0032","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.fertnstert.2007.11.090","article-title":"Soluble Fas and gonadal hormones in infertile men with varicocele","volume":"91","author":"Zedan","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1111\/and.13066-BIB0033|and13066-cit-0033","doi-asserted-by":"crossref","first-page":"6993","DOI":"10.4049\/jimmunol.0802502","article-title":"Granulysin induces Cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of bid leading to necroptosis","volume":"182","author":"Zhang","year":"2009","journal-title":"The Journal of Immunology"},{"key":"10.1111\/and.13066-BIB0034|and13066-cit-0034","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/01485019808988544","article-title":"Loss of left testicular volume in men with clinical left varicocele: Correlation with grade of varicocele","volume":"41","author":"Zini","year":"1998","journal-title":"Archives of Andrology"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.13066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.13066\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T04:49:06Z","timestamp":1693716546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.13066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1111\/and.13066","archive":["Portico"],"relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6,13]]}}}