{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:06:08Z","timestamp":1788343568197,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671443"],"award-info":[{"award-number":["81671443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601270"],"award-info":[{"award-number":["81601270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1111\/and.13070","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T10:18:22Z","timestamp":1531304302000},"page":"e13070","source":"Crossref","is-referenced-by-count":21,"title":["Effect of adjuvant drug therapy after varicocelectomy on fertility outcome in males with varicocele-associated infertility: Systematic review and meta-analysis"],"prefix":"10.1155","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5364-2299","authenticated-orcid":false,"given":"Yin-Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology; Wuhan Hubei China"},{"name":"Institute of Urology; Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hua","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Urology; Wuhan Hubei China"},{"name":"Institute of Urology; Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao-Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology; Wuhan Hubei China"},{"name":"Institute of Urology; Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology; Wuhan Hubei China"},{"name":"Institute of Urology; Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurab","family":"Pokhrel","sequence":"additional","affiliation":[{"name":"Department of Urology; Wuhan Hubei China"},{"name":"Institute of Urology; Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology; Wuhan Hubei China"},{"name":"Institute of Urology; Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology; Wuhan Hubei China"},{"name":"Institute of Urology; Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology; Wuhan Hubei China"},{"name":"Institute of Urology; Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology; Wuhan Hubei China"},{"name":"Institute of Urology; Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"10.1111\/and.13070-BIB0100|and13070-cit-0100","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.juro.2011.09.041","article-title":"Time for improvement in semen parameters after varicocelectomy","volume":"187","author":"Al Bakri","year":"2012","journal-title":"Journal of Urology"},{"key":"10.1111\/and.13070-BIB0200|and13070-cit-0200","first-page":"441","article-title":"Comparison of recombinant human follicle stimulating hormone (rhFSH), human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) on semen parameters after varicocelectomy: A randomized clinical trial","volume":"10","author":"Amirzargar","year":"2012","journal-title":"Iranian Journal of Reproductive Medicine"},{"key":"10.1111\/and.13070-BIB0300|and13070-cit-0300","doi-asserted-by":"crossref","DOI":"10.5812\/numonthly.59939","article-title":"The effect of saffron on semen analysis in infertile men with clinical varicocele after varicocelectomy","volume":"9","author":"Asr Badr","year":"2017","journal-title":"Nephro-Urology Monthly"},{"key":"10.1111\/and.13070-BIB0004|and13070-cit-0004","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2605.2010.01112.x","article-title":"Zaditen (Ketotifen), as mast cell blocker, improves sperm quality, chromatin integrity and pregnancy rate after varicocelectomy","volume":"34","author":"Azadi","year":"2011","journal-title":"International Journal of Andrology"},{"key":"10.1111\/and.13070-BIB0001|and13070-cit-0001","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10815-013-9961-9","article-title":"Effects of supplement therapy on sperm parameters, protamine content and acrosomal integrity of varicocelectomized subjects","volume":"30","author":"Azizollahi","year":"2013","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"10.1111\/and.13070-BIB0005|and13070-cit-0005","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.eururo.2011.06.018","article-title":"Varicocele and male factor infertility treatment: A new meta-analysis and review of the role of varicocele repair","volume":"60","author":"Baazeem","year":"2011","journal-title":"European Urology"},{"key":"10.1111\/and.13070-BIB0006|and13070-cit-0006","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1046\/j.1464-410x.1999.00353.x","article-title":"The effect of microsurgical varicocelectomy on serum follicle stimulating hormone, testosterone and free testosterone levels in infertile men with varicocele","volume":"84","author":"Cayan","year":"1999","journal-title":"BJU International"},{"key":"10.1111\/and.13070-BIB0007|and13070-cit-0007","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2164\/jandrol.108.005967","article-title":"Treatment of palpable varicocele in infertile men: A meta-analysis to define the best technique","volume":"30","author":"Cayan","year":"2009","journal-title":"Journal of Andrology"},{"key":"10.1111\/and.13070-BIB0008|and13070-cit-0008","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0015-0282(16)54796-7","article-title":"Deterioration of semen parameters over time in men with untreated varicocele: Evidence of progressive testicular damage","volume":"57","author":"Chehval","year":"1992","journal-title":"Fertility and Sterility"},{"key":"10.1111\/and.13070-BIB0009|and13070-cit-0009","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/1008-682X.170441","article-title":"Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation","volume":"18","author":"Cho","year":"2016","journal-title":"Asian Journal of Andrology"},{"key":"10.1111\/and.13070-BIB0010|and13070-cit-0010","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1590\/S1677-5538.IBJU.2015.02.07","article-title":"The effect of adjuvant vitamin C after varicocele surgery on sperm quality and quantity in infertile men: A double blind placebo controlled clinical trial","volume":"41","author":"Cyrus","year":"2015","journal-title":"International Brazilian Journal of Urology"},{"key":"10.1111\/and.13070-BIB0011|and13070-cit-0011","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.eururo.2016.06.044","article-title":"Varicocele is associated with impaired semen quality and reproductive hormone levels: A study of 7035 healthy young men from six European countries","volume":"70","author":"Damsgaard","year":"2016","journal-title":"European Urology"},{"key":"10.1111\/and.13070-BIB0012|and13070-cit-0012","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/and.12521","article-title":"The impact of vitamin E supplementation on semen parameters and pregnancy rates after varicocelectomy: A randomised controlled study","volume":"48","author":"Ener","year":"2016","journal-title":"Andrologia"},{"key":"10.1111\/and.13070-BIB0013|and13070-cit-0013","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(03)13503-9","article-title":"Assessment of efficacy of varicocele repair for male subfertility: A systematic review","volume":"361","author":"Evers","year":"2003","journal-title":"Lancet"},{"key":"10.1111\/and.13070-BIB0014|and13070-cit-0014","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.eururo.2005.11.023","article-title":"Treatment of varicocele in subfertile men: The Cochrane Review-a contrary opinion","volume":"49","author":"Ficarra","year":"2006","journal-title":"European Urology"},{"key":"10.1111\/and.13070-BIB0015|and13070-cit-0015","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4103\/1008-682X.171657","article-title":"An update on the role of medical treatment including antioxidant therapy in varicocele","volume":"18","author":"Garg","year":"2016","journal-title":"Asian Journal of Andrology"},{"key":"10.1111\/and.13070-BIB0016|and13070-cit-0016","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1365-2605.2007.00753.x","article-title":"Oxidative stress biomarkers and hormonal profile in human patients undergoing varicocelectomy","volume":"30","author":"Hurtado de Catalfo","year":"2007","journal-title":"International Journal of Andrology"},{"key":"10.1111\/and.13070-BIB0017|and13070-cit-0017","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrurol.2017.98","article-title":"Varicocele and male infertility","volume":"14","author":"Jensen","year":"2017","journal-title":"Nature Reviews Urology"},{"key":"10.1111\/and.13070-BIB0018|and13070-cit-0018","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.eururo.2012.04.048","article-title":"European association of urology guidelines on male infertility: The 2012 update","volume":"62","author":"Jungwirth","year":"2012","journal-title":"European Urology"},{"key":"10.1111\/and.13070-BIB0019|and13070-cit-0019","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.fertnstert.2006.12.008","article-title":"Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis","volume":"88","author":"Marmar","year":"2007","journal-title":"Fertility and Sterility"},{"key":"10.1111\/and.13070-BIB0020|and13070-cit-0020","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/humupd\/7.5.473","article-title":"Pathophysiology of varicoceles in male infertility","volume":"7","author":"Naughton","year":"2001","journal-title":"Human Reproduction Update"},{"key":"10.1111\/and.13070-BIB0002|and13070-cit-0002","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/and.12067","article-title":"Effect of folic acid and zinc sulphate on endocrine parameters and seminal antioxidant level after varicocelectomy","volume":"46","author":"Nematollahi-Mahani","year":"2014","journal-title":"Andrologia"},{"key":"10.1111\/and.13070-BIB0003|and13070-cit-0003","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s11655-015-2139-9","article-title":"Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study","volume":"22","author":"Park","year":"2016","journal-title":"Chinese Journal of Integrative Medicine"},{"key":"10.1111\/and.13070-BIB0021|and13070-cit-0021","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0094-0143(21)01755-9","article-title":"Varicocele","volume":"14","author":"Pryor","year":"1987","journal-title":"Urologic Clinics of North America"},{"key":"10.1111\/and.13070-BIB0022|and13070-cit-0022","first-page":"1247","article-title":"Curative effect of surgery in combination with compound xuanju capsule in treating subclinical varicocele induced infertility","volume":"28","author":"Qu","year":"2017","journal-title":"Biomedical Research (India)"},{"key":"10.1111\/and.13070-BIB0023|and13070-cit-0023","doi-asserted-by":"crossref","first-page":"912878","DOI":"10.1155\/2014\/912878","article-title":"Free radicals in adolescent varicocele testis","volume":"2014","author":"Romeo","year":"2014","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1111\/and.13070-BIB0024|and13070-cit-0024","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1464-410X.2008.07517.x","article-title":"The assessment of oxidative stress in infertile patients with varicocele","volume":"101","author":"Sakamoto","year":"2008","journal-title":"BJU International"},{"key":"10.1111\/and.13070-BIB0025|and13070-cit-0025","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.juro.2011.12.084","article-title":"The impact of varicocelectomy on sperm parameters: A meta-analysis","volume":"187","author":"Schauer","year":"2012","journal-title":"Journal of Urology"},{"key":"10.1111\/and.13070-BIB0026|and13070-cit-0026","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/andr.12445","article-title":"Effect of varicocelectomy and\/or mast cells stabilizer on sperm DNA fragmentation in infertile patients with varicocele","volume":"6","author":"Zaazaa","year":"2018","journal-title":"Andrology"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.13070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.13070\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:37:33Z","timestamp":1671539853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.13070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1111\/and.13070","archive":["Portico"],"relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,11]]}}}