{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:34:21Z","timestamp":1761129261717},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000592","name":"Fulbright Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Male patients with terminal renal failure are often infertile and exhibit an abnormal sex hormone pattern in plasma. We studied patients in all chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) stages to determine plasma levels of anti\u2010M\u00fcllerian hormone (<jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>), a Sertoli cell\u2010derived marker, and other sex hormones. Seventy\u2010eight male patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stages 1\u20135 and a median age of 40\u00a0years (22\u201350\u00a0years), as well as 20 healthy controls with a median age of 37\u00a0years (26\u201344\u00a0years), were enrolled. The <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> patients were evenly distributed; 18 with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stages 1\u20132, 19 with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 3, 19 with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 4, and 22 with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 5. Cystatin C, follicle\u2010stimulating hormone, luteinizing hormone, prolactin, sex hormone\u2010binding globulin, testosterone, and <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> levels in plasma were analysed. <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> was analysed using the Ansh Labs UltraSensitive <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> assay. Several changes occurred in plasma levels of sex hormones in male patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. Plasma <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> levels were lower in <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stages 1\u20134 by 30% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.041) and by 70% (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) in <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 5 compared with controls. Plasma luteinizing hormone and prolactin levels were higher and testosterone levels were lower compared with controls. The pathophysiological role of this reduction in <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> is unclear, but can be linked to altered Sertoli cell function.<\/jats:p>","DOI":"10.1111\/andr.12116","type":"journal-article","created":{"date-parts":[[2015,10,10]],"date-time":"2015-10-10T06:33:46Z","timestamp":1444458826000},"page":"1160-1164","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010M\u00fcllerian hormone, a Sertoli cell\u2010derived marker, is decreased in plasma of male patients in all stages of chronic kidney disease"],"prefix":"10.1111","volume":"3","author":[{"given":"D.","family":"Eckersten","sequence":"first","affiliation":[{"name":"Department of Nephrology Sk\u00e5ne University Hospital Lund University Malm\u00f6 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