{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:05:23Z","timestamp":1783469123118,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T00:00:00Z","timestamp":1449792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI1100357"],"award-info":[{"award-number":["PI1100357"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To study the prevalence of male obesity\u2010secondary hypogonadism (<jats:styled-content style=\"fixed-case\">MOSH<\/jats:styled-content>) in patients with moderate to severe obesity, we performed a prospective prevalence study including 100 male patients with moderate to severe obesity at a university tertiary hospital. Total testosterone (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>) and sex hormone\u2010binding globulin (<jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>) concentrations among others were assayed in all patients. Serum\u2010free testosterone (<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>) concentration was calculated from <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content> levels. Semen analysis was conducted in 31 patients. We found a prevalence of 45% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 35\u201355%) when considering decreased <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> concentrations. Serum concentrations of <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> were correlated negatively with glucose (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.328, <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and insulin resistance (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.261, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011). The same occurred with <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> and glucose (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.340, <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and insulin resistance (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.246, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.016). Sixty\u2010two percent (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 39\u201385%) of the patients with seminogram also presented abnormal results in semen analysis. The frequencies of low <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> or low <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> values were similar in patients with abnormal or normal semen analysis (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.646 and <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.346, respectively). Ejaculate volume inversely correlated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (\u03c1\u00a0=\u00a0\u22120.400, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.029) and with excess body weight (\u03c1\u00a0=\u00a0\u22120.464, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.010). Our data show the prevalence of <jats:styled-content style=\"fixed-case\">MOSH<\/jats:styled-content> in patients with moderate to severe obesity is high. Low circulating testosterone is associated with insulin resistance and low ejaculate volume with higher <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and excess body weight. Semen analysis must be performed in these patients when considering fertility whether or not presenting low circulating testosterone.<\/jats:p>","DOI":"10.1111\/andr.12135","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T15:10:36Z","timestamp":1449933036000},"page":"62-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Prevalence of male secondary hypogonadism in moderate to severe obesity and its relationship with insulin resistance and excess body weight"],"prefix":"10.1111","volume":"4","author":[{"given":"Berniza","family":"Calder\u00f3n","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital Universitario Ram\u00f3n y Cajal &amp; Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas M.","family":"G\u00f3mez\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital Universitario Ram\u00f3n y Cajal &amp; Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Vega\u2010Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital Universitario Ram\u00f3n y Cajal &amp; Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Mart\u00edn\u2010Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\u2010Research Hospital Universitario Ram\u00f3n y Cajal &amp; Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Fisiopatolog\u00eda de Obesidad y Nutrici\u00f3n (CIBERobn) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Galindo","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Luque\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital Universitario Ram\u00f3n y Cajal &amp; Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor F.","family":"Escobar\u2010Morreale","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital Universitario Ram\u00f3n y Cajal &amp; Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 I.","family":"Botella\u2010Carretero","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital Universitario Ram\u00f3n y Cajal &amp; Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Fisiopatolog\u00eda de Obesidad y Nutrici\u00f3n (CIBERobn) Madrid 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