{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:38:33Z","timestamp":1784864313748,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008252","name":"University of Udine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008252","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012306","name":"University of Trieste","doi-asserted-by":"crossref","award":["2012-2014"],"award-info":[{"award-number":["2012-2014"]}],"id":[{"id":"10.13039\/501100012306","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Concern regarding adverse effects of finasteride is increasing. We aimed to determine the type and frequency of symptoms in men having long\u2010term sexual and non\u2010sexual side effects after finasteride treatment (a condition recently called post\u2010finasteride syndrome, PFS) against androgenetic alopecia (AGA). Subjects were recruited at the Urology Unit of the Trieste University\u2010Hospital, and from a dedicated website. Out of 79 participants, 34% were white Italians, mean age was 33.4\u00a0\u00b1\u00a07.60\u00a0years, mean duration of finasteride use was 27.3\u00a0\u00b1\u00a033.21\u00a0months; mean time from finasteride discontinuation was 44.1\u00a0\u00b1\u00a034.20\u00a0months. Symptoms were investigated by an ad hoc 100 questions' questionnaire, and by validated Arizona Sexual Experience Scale (ASEX) and Aging Male Symptom Scale (AMS) questionnaires. By ASEX questionnaire, 40.5% of participants declared getting and keeping erection very difficult, and 3.8% never achieved; reaching orgasm was declared very difficult by 16.5%, and never achieved by 2.5%. By the ad hoc questionnaire, the most frequent sexual symptoms referred were loss of penis sensitivity (87.3%), decreased ejaculatory force (82.3%), and low penile temperature (78.5%). The most frequent non\u2010sexual symptoms were reduced feeling of life pleasure or emotions (anhedonia) (75.9%); lack of mental concentration (72.2%), and loss of muscle tone\/mass (51.9%). We contributed to inform about symptoms of PFS patients; unexpectedly loss of penis sensitivity was more frequent than severe erectile dysfunction and loss of muscle tone\/mass was affecting half of the subjects. Further studies are necessary to investigate the pathophysiological and biochemical pathways leading to the post\u2010finasteride syndrome.<\/jats:p>","DOI":"10.1111\/andr.12147","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T09:15:09Z","timestamp":1452762909000},"page":"245-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["An observational retrospective evaluation of 79 young men with long\u2010term adverse effects after use of finasteride against androgenetic alopecia"],"prefix":"10.1111","volume":"4","author":[{"given":"G.","family":"Chiriac\u00f2","sequence":"first","affiliation":[{"name":"Urological Hospital Department Department of Medical, Surgical and Health Sciences University of\u00a0Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cauci","sequence":"additional","affiliation":[{"name":"Department of Medical and Biological Sciences School of Medicine University of Udine Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mazzon","sequence":"additional","affiliation":[{"name":"Urological Hospital Department Department of Medical, Surgical and Health Sciences University of\u00a0Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Trombetta","sequence":"additional","affiliation":[{"name":"Urological Hospital Department Department of Medical, Surgical and Health Sciences University of\u00a0Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2009.10.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1612"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.36"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5301\/jbm.5000095"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100237"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1557988314538445"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-4-1136"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199210223271701"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-15"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-23"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.1830"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000158"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02255.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.048"},{"key":"e_1_2_9_16_1","first-page":"S8","article-title":"Preliminary evidence of a peculiar hormonal profile in men with adverse effects after use of finasteride against androgenetic alopecia","volume":"181","author":"La Marra F","year":"2012","journal-title":"Am J Pathol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02548-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/009262300278623"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12269"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.256"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1998.00554.x"},{"key":"e_1_2_9_22_1","first-page":"1251","article-title":"Efficacy and safety of finasteride therapy for benign prostatic hyperplasia: results of a 2\u2010year randomized controlled trial (the PROSPECT study). PROSCAR Safety Plus Efficacy Canadian Two Year Study","volume":"155","author":"Nickel JC","year":"1996","journal-title":"CMAJ"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197511000-00009"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.02.015"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.006007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02157.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1515\/hmbci-2014-0025","article-title":"5alpha\u2010Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis","volume":"20","author":"Traish AM","year":"2014","journal-title":"Horm Mol Biol Clin Investig"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2014.55.6.367"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1515\/hmbci-2015-0015","article-title":"Finasteride, not tamsulosin, increases severity of erectile dysfunction and decreases testosterone levels in men with benign prostatic hyperplasia","volume":"23","author":"Traish AM","year":"2015","journal-title":"Horm Mol Biol Clin Investig"},{"key":"e_1_2_9_30_1","first-page":"1","article-title":"Adverse effects of 5alpha\u2010reductase inhibitors: what do we know, don't know, and need to know?","volume":"2015","author":"Traish AM","year":"2015","journal-title":"Rev Endocr Metab Disord"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/HMBCI.2010.035"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02661.x"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T20:06:40Z","timestamp":1718309200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,13]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/andr.12147"],"URL":"https:\/\/doi.org\/10.1111\/andr.12147","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,13]]},"assertion":[{"value":"2015-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}