{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:18:14Z","timestamp":1773757094232,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25\u201003102"],"award-info":[{"award-number":["25\u201003102"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cryptorchidism, a common anomaly of the male genitalia, affects 2\u20134% of male infants. The post\u2010fertilization effects of unilateral cryptorchidism model in the rat and the effects of antioxidant treatment were investigated. Six\u2010week\u2010old male Wistar rats were randomly separated into four groups. Unilateral cryptorchidism was induced in the right testis of three groups. One group was treated with saline intraperitoneally (i.p.) (Crypto), one group was treated with taurine (500\u00a0mg\/kg, i.p.; Tau), and another group was treated with sivelestat (15\u00a0mg\/kg i.p.; Siv). The control group was treated with saline i.p. The treatment was daily for 8\u00a0weeks. Five days before sacrifice, mating studies were performed. Body, testicular, and epididymal weights were recorded. Malondialdehyde (<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>) levels in the seminal vesicular fluid (<jats:styled-content style=\"fixed-case\">SVF<\/jats:styled-content>) were measured. Testicular levels of <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> and 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine (8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG) were determined bilaterally. <jats:styled-content style=\"fixed-case\">TUNEL<\/jats:styled-content> assay was used to examine <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation bilaterally. Histological examination and the Johnsen score were used to evaluate morphological testicular alterations. The Crypto group demonstrated significantly lower right testicular and epididymal weights, significantly increased <jats:styled-content style=\"fixed-case\">SVF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> levels, testicular <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> and 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG levels, and the apoptotic score bilaterally compared to the controls. Furthermore, histological evaluation revealed significantly reduced spermatogenesis and mild injury to the cryptorchid testes compared to the control. Treatment with both taurine and sivelestat significantly reduced <jats:styled-content style=\"fixed-case\">SVF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> levels, testicular <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>, 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG, and apoptosis bilaterally compared to the Crypto group. Antioxidant treatment was unable to ameliorate spermatogenesis. Newborns delivered by females that mated with Crypto\u2010males had significantly lower body weight compared with the respective animals from the control, Tau and Siv groups. The present study demonstrated that unilateral cryptorchidism\u2010induced testicular damage can significantly affect the contralateral testis as well having further deleterious post\u2010fertilization effect on the development of newborns. Treatment with antioxidants can partially improve the testicular damage bilaterally with beneficial effects for the newborns.<\/jats:p>","DOI":"10.1111\/andr.12154","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T01:27:26Z","timestamp":1452648446000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Post\u2010fertilization effect of bilateral primary testicular damage induced by unilateral cryptorchidism in the rat model"],"prefix":"10.1111","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-8653","authenticated-orcid":false,"given":"P.","family":"Tsounapi","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery Tottori University School of Medicine Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Honda","sequence":"additional","affiliation":[{"name":"Division of Urology 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