{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:01:02Z","timestamp":1790290862843,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Accumulating evidence from animal and human studies suggests that vitamin D, apart from its regulatory effects on musculoskeletal health, is involved in reproductive function in both genders. The basis of the interplay between vitamin D and reproduction lays on the presence of both vitamin D receptor (<jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>) and 1\u03b1\u2010hydroxylase (<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>27B1) enzyme in reproductive organs. In males, <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content> are present in testis, epididymis, prostate, and seminal vesicles. In Sertoli cells, whose secretory activities are ion channel\u2010dependent, vitamin D has been shown to stimulate calcium uptake through a nuclear receptor activity. Epidemiological studies support a positive association between serum 25\u2010hydroxy\u2010vitamin D [25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D] concentrations and sperm motility in both fertile and infertile men In addition, large multi\u2010center, cross\u2010sectional studies from Europe and <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> have shown positive, linear association between 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D and androgen concentrations. On the contrary, there are studies that support an inverse U\u2010shaped association, that is, men with both low and high 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D concentrations demonstrate poorer gonadal function compared with those with intermediate concentrations. Given the rapid increase in over\u2010the\u2010counter use of vitamin D supplements by men that anticipate advantageous health outcomes, the aim of the present commentary is to provide an overview of the studies that present either U\u2010shaped or linear association between 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D concentrations and male gonadal function.<\/jats:p>","DOI":"10.1111\/andr.12173","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T02:09:37Z","timestamp":1458353377000},"page":"542-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Vitamin D and gonadal function in men: a potential inverse U\u2010shaped association?"],"prefix":"10.1111","volume":"4","author":[{"given":"S.","family":"Karras","sequence":"first","affiliation":[{"name":"Unit of Reproductive Endocrinology First Department of Obstetrics and Gynecology Medical School Aristotle University of Thessaloniki Thessaloniki Greece"},{"name":"First Department of Internal Medicine Division of Endocrinology and Metabolism Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Anagnostis","sequence":"additional","affiliation":[{"name":"Unit of Reproductive Endocrinology First Department of Obstetrics and Gynecology Medical School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kotsa","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Division of Endocrinology and Metabolism Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. G.","family":"Goulis","sequence":"additional","affiliation":[{"name":"Unit of Reproductive Endocrinology First Department of Obstetrics and Gynecology Medical School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12031"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.262"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der059"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.09.011"},{"key":"e_1_2_6_7_1","first-page":"1082","article-title":"Efficacy and safety of vitamin D in the treatment of idiopathic oligoasthenozoospermia","volume":"20","author":"Deng XL","year":"2014","journal-title":"Zhonghua Nan Ke Xue"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1628"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03216108"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2012.77"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0743"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2014.00247.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1387789"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04332.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1269854"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.11.002"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01091-4"},{"key":"e_1_2_6_18_1","first-page":"381","article-title":"Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility","volume":"12","author":"Tiwari A","year":"2009","journal-title":"IDrugs"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0068-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03777.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2012.01287.x"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T08:00:40Z","timestamp":1695024040000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,16]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/andr.12173"],"URL":"https:\/\/doi.org\/10.1111\/andr.12173","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,16]]},"assertion":[{"value":"2015-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}