{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:18:59Z","timestamp":1770484739348,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Royal Hallamshire Hospital Cardiology Research Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>There is a clear association between low serum testosterone and coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) in men. Hypotestosteronaemia is associated with accelerated atherosclerosis and a quarter of men with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> are biochemically hypogonadal. Amongst those with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>, hypotestosteronaemia is associated with increased mortality. Testosterone vasodilates coronary arteries, and exogenous testosterone reduces ischaemia. Whether hypotestosteronaemia is a cause or a consequence of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> remains unanswered. The aim of this prospective observational study was to investigate whether coronary revascularization affected androgen status in men with stable angina pectoris. Twenty five men (mean age 62.7, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 9.18) with angiographically significant <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> and symptomatic angina underwent full coronary revascularization by percutaneous coronary intervention. Androgen status and symptoms of angina, stress, depression and sexual function were assessed before, and at one and 6\u00a0months after the coronary revascularization. All patients underwent complete revascularization which was associated with a significant reduction in angina symptoms and ischaemia. No significant difference was seen in total testosterone (11.33\u00a0nmol\/L baseline; 12.56, 1\u00a0month post; 13.04 at 6\u00a0months; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.08). A significant and sustained rise in sex hormone\u2010binding globulin was seen (33.99\u00a0nm\/L baseline; 36.11\u00a0nm\/L 1\u00a0month post <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>; 37.94\u00a0nm\/L at 6\u00a0months; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) Overall, there was no significant alteration in any other marker of androgen status including free testosterone or bioavailable testosterone. There was no change in symptoms of anxiety, depression or sexual function. Coronary revascularization has no sustained effect on androgen status. This supports the hypothesis that hypotestosteronaemia is not a consequence of angina pectoris or myocardial ischaemia.<\/jats:p>","DOI":"10.1111\/andr.12189","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T20:32:22Z","timestamp":1459456342000},"page":"486-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Revascularization with percutaneous coronary intervention does not affect androgen status in males with chronic stable angina pectoris"],"prefix":"10.1111","volume":"4","author":[{"given":"J. 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