{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:20:43Z","timestamp":1787318443937,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,16]],"date-time":"2016-10-16T00:00:00Z","timestamp":1476576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Fund of Istanbul Medeniyet University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Summary<\/jats:title>\n \n We aimed to compare the preventive effects of combined antioxidants (\n CA<\/jats:styled-content>\n 1, 2) with a single antioxidant drug (thymoquinone;\n TQ<\/jats:styled-content>\n ) on experimental testis Ischemia\/Reperfusion (I\/R) injury. Thirty\u2010five adult male Wistar rats were divided into five groups of seven rats each: control, testis I\/R, testis I\/R\u00a0+\u00a0\n CA<\/jats:styled-content>\n 1, testis I\/R\u00a0+\u00a0\n CA<\/jats:styled-content>\n 2, and testis I\/R\u00a0+\u00a0\n TQ<\/jats:styled-content>\n . After 1\u00a0h of testicular ischemia, reperfusion was achieved by detorsion for 4\u00a0h. Antioxidants were intraperitoneally administered for 30\u00a0min prior to reperfusion. All rats were sacrificed 4\u00a0h after reperfusion to evaluate the tissue levels of malondialdehyde (\n MDA<\/jats:styled-content>\n ) and total antioxidant status (\n TAS<\/jats:styled-content>\n ) and the immunohistochemical evaluation of tissue inducible and endothelial nitric acid synthase (\n iNOS<\/jats:styled-content>\n ,\n eNOS<\/jats:styled-content>\n ) and apoptosis protease\u2010activating factor 1 (\n APAF<\/jats:styled-content>\n \u20101).\n MDA<\/jats:styled-content>\n levels were lower and\n TAS<\/jats:styled-content>\n values were higher in the I\/R\u00a0+\u00a0antioxidant groups than in the I\/R group (\n p<\/jats:italic>\n \u00a0<\u00a00.05).\n iNOS<\/jats:styled-content>\n and\n eNOS<\/jats:styled-content>\n levels in the I\/R\u00a0+\u00a0antioxidant groups were also lower than those in the I\/R group (\n p<\/jats:italic>\n \u00a0<\u00a00.05). There were no significant differences between the\n CA<\/jats:styled-content>\n groups and the\n TQ<\/jats:styled-content>\n group according to aforementioned parameters. In addition, tissue\n APAF<\/jats:styled-content>\n \u20101 values were significantly higher in the I\/R group than in the other groups. However, there was a significant difference between the\n TQ<\/jats:styled-content>\n and\n CA<\/jats:styled-content>\n groups in\n APAF<\/jats:styled-content>\n \u20101 levels, which were highest in the\n TQ<\/jats:styled-content>\n group (\n p<\/jats:italic>\n \u00a0<\u00a00.05). Although\n TQ<\/jats:styled-content>\n alone increased\n TAS<\/jats:styled-content>\n values and reduced tissue\n iNOS<\/jats:styled-content>\n and\n eNOS<\/jats:styled-content>\n levels, combined antioxidant treatment may more effectively reduce apoptosis and increase preventive effects in testis I\/R injury.\n <\/jats:p>","DOI":"10.1111\/andr.12268","type":"journal-article","created":{"date-parts":[[2016,10,16]],"date-time":"2016-10-16T22:22:56Z","timestamp":1476656576000},"page":"119-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of combined antioxidants and thymoquinone in the prevention of testis ischemia \u2013 reperfusion injury"],"prefix":"10.1111","volume":"5","author":[{"given":"B.","family":"Erol","sequence":"first","affiliation":[{"name":"Department of Urology School of Medicine Istanbul Medeniyet University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Istanbul Medeniyet University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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A.","family":"Alkoc","sequence":"additional","affiliation":[{"name":"Department of Anatomy School of Medicine Istanbul Medeniyet University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Caskurlu","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Istanbul Medeniyet University Istanbul 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