{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:06Z","timestamp":1787013846722,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501245"],"award-info":[{"award-number":["81501245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270694"],"award-info":[{"award-number":["81270694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Ejaculation is mediated by a spinal generator, which integrates inputs related to the sexual activity and coordinates sympathetic, parasympathetic, and motor outflow. Previous clinical studies indicate that primary premature ejaculation is related to the hyperactivity of the sympathetic nervous system. In this study, we explored the roles of N\u2010methyl\u2010D\u2010aspartic acid (\n                    <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>\n                    ) receptors in paraventricular nucleus of the hypothalamus (\n                    <jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content>\n                    ) on ejaculatory responses and its potential mechanism in the rats. We found that microinjection of 0.20\u00a0nmol\n                    <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>\n                    into the\n                    <jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content>\n                    reduced the latency of intromission and facilitated ejaculation during copulation. Moreover, delayed ejaculation and intromission were observed after the rats were microinjected with\n                    <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>\n                    receptor antagonist D (\u2212)\u20102\u2010Amino\u20105\u2010phosphonopentanoic acid (\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    \u20105). However, we discovered that microinjection of\n                    <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>\n                    into\n                    <jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content>\n                    significantly increased baseline lumbar splanchnic nerve activity (\n                    <jats:styled-content style=\"fixed-case\">LSNA<\/jats:styled-content>\n                    ), and the\n                    <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>\n                    dose was positively correlated with the increased\n                    <jats:styled-content style=\"fixed-case\">LSNA<\/jats:styled-content>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.875,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.04). Meanwhile, the plasma norepinephrine level in rats injected with\n                    <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>\n                    was much higher than that in rats injected with saline (1453.4\u00a0\u00b1\u00a0136.4\u00a0pg\/mL vs. 492.3\u00a0\u00b1\u00a036.8\u00a0pg\/mL,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.01). Additionally,\n                    <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\n                    \u20105 reduced the baseline\n                    <jats:styled-content style=\"fixed-case\">LSNA<\/jats:styled-content>\n                    and abrogated the enhancing activity of\n                    <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>\n                    in\n                    <jats:styled-content style=\"fixed-case\">LSNA<\/jats:styled-content>\n                    . Thus, we propose that\n                    <jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>\n                    receptors in\n                    <jats:styled-content style=\"fixed-case\">PVN<\/jats:styled-content>\n                    may facilitate ejaculation through enhancing the activity of sympathetic system.\n                  <\/jats:p>","DOI":"10.1111\/andr.12274","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T22:51:50Z","timestamp":1479336710000},"page":"153-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N\u2010methyl\u2010D\u2010aspartic acid receptors in paraventricular nucleus"],"prefix":"10.1111","volume":"5","author":[{"given":"J.\u2010D.","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nanjing Drum Tower Hospital Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010J.","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Disease and Molecular Intervention Department of Physiology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.\u2010H.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.\u2010Q.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Disease and Molecular Intervention Department of Physiology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010T.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Andrology Nanjing Drum Tower Hospital Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00088-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-004-0494-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.09.034"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00143-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.268763"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.05163"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990333"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12125"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02450.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.05.055"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.02.020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000703)422:3<352::AID-CNE3>3.0.CO;2-F"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2013.00146.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.4.3_Pt_2.166"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19980915)42:6<398::AID-JEMT3>3.0.CO;2-J"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(98)00007-9"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.6.H2328"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90554-2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90147-3"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90638-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2004.10109.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90517-7"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009850224802"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04252.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2011.11.002"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707366"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90738-1"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02941.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64146-8"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00183-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(79)90025-6"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12654"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2013.23"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91534-L"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.041632"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.046565"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20445"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.08.029"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T05:43:39Z","timestamp":1694929419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/andr.12274"],"URL":"https:\/\/doi.org\/10.1111\/andr.12274","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]},"assertion":[{"value":"2016-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}