{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:30:37Z","timestamp":1779309037532,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Obesity is reported to have adverse effects on semen quality and the endocrine system. In this study, we evaluated the effect of obesity on sperm retrieval outcome and reproductive hormone levels in Japanese men with non\u2010obstructive azoospermia (<jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content>). This study is based on the clinical records of 217 men [172 with a 46,<jats:styled-content style=\"fixed-case\">XY<\/jats:styled-content> karyotype, 45 with Klinefelter syndrome (<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>)] with <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content> who underwent microdissection testicular sperm extraction at Nagoya City University Hospital between January 2004 and December 2014. Body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and serum levels of luteinizing hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>), follicle\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>), and total testosterone (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>) were measured in all patients. In a subset of patients, bioavailable testosterone (<jats:styled-content style=\"fixed-case\">cBAT<\/jats:styled-content>) also was calculated. Values were evaluated separately in patients with and without <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>. Sperm retrieval rates (<jats:styled-content style=\"fixed-case\">SRR<\/jats:styled-content>s) in 46,<jats:styled-content style=\"fixed-case\">XY<\/jats:styled-content> men with a <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> &lt;25\u00a0kg\/m<jats:sup>2<\/jats:sup> and \u226525\u00a0kg\/m<jats:sup>2<\/jats:sup> were 29.3% and 18.4%, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.142), while <jats:styled-content style=\"fixed-case\">SRR<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> men with a <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> &lt;25\u00a0kg\/m<jats:sup>2<\/jats:sup> and \u226525\u00a0kg\/m<jats:sup>2<\/jats:sup> were 25.0% and 35.3%, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.460). <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> level in men with a <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> \u226525\u00a0kg\/m<jats:sup>2<\/jats:sup> was lower than that in men with a <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> &lt;25\u00a0kg\/m<jats:sup>2<\/jats:sup>, regardless of <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> status. According to Pearson product\u2010moment correlation coefficients, <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">cBAT<\/jats:styled-content> levels tended to have negative correlations with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>; however, statistical significance was observed only for <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> level in 46,<jats:styled-content style=\"fixed-case\">XY<\/jats:styled-content> men (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.340, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> levels were negatively correlated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> men (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.466, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001 and <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.647, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, respectively), but not in 46,<jats:styled-content style=\"fixed-case\">XY<\/jats:styled-content> men. These results suggest that obesity may be irrelevant to sperm retrieval outcome in patients with <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content>. The negative correlations between gonadotropins and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> suggest an underlying suppressive effect on gonadotropin excretion, which is distinctive in obese patients with <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/andr.12281","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T21:12:45Z","timestamp":1474492365000},"page":"82-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of obesity on sperm retrieval outcome and reproductive hormone levels in Japanese azoospermic men with and without Klinefelter syndrome"],"prefix":"10.1111","volume":"5","author":[{"given":"S.","family":"Iwatsuki","sequence":"first","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hamakawa","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-2914","authenticated-orcid":false,"given":"Y.","family":"Umemoto","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02246.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S67400"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061466"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0145"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10813.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.122365"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep431"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev057"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2382"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/183302a0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-2-11-615"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16678-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.006460"},{"key":"e_1_2_7_15_1","first-page":"18","article-title":"New cutoffs of obesity and diagnostic criteria for \u2018obesity disease\u2019 [in Japanese]","volume":"6","author":"Matsuzawa Y","year":"2000","journal-title":"Himan Kenkyu"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaq027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.10.025"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.09.021"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.1.131"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.1382"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S190"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60813-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02235.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr017"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.6079"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-013-0262-6"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12281","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T09:43:45Z","timestamp":1694943825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,21]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/andr.12281"],"URL":"https:\/\/doi.org\/10.1111\/andr.12281","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,21]]},"assertion":[{"value":"2016-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}