{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:35:51Z","timestamp":1791326151754,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P3\u20100326"],"award-info":[{"award-number":["P3\u20100326"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to examine whether there is an association among genetic variability in leptin (<jats:italic><jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content><\/jats:italic>) and leptin receptor (<jats:italic><jats:styled-content style=\"fixed-case\">LEPR<\/jats:styled-content><\/jats:italic>) genes and male infertility. We performed a case\u2013control study and were searching for an association between polymorphisms of <jats:italic><jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">LEPR<\/jats:styled-content><\/jats:italic> genes and male infertility. The study group consisted of 317 patients with idiopathic infertility and a control group of 241 fertile men from Slovenia. Four single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in <jats:italic><jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content><\/jats:italic> gene and four single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in <jats:italic><jats:styled-content style=\"fixed-case\">LEPR<\/jats:styled-content><\/jats:italic> gene were chosen and genotyped. Statistically significant <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> was further validated in additional 255 infertile patients and 168 controls from Serbia and Macedonia. In the Slovenian population, we found a statistically significant difference in genotype distribution for rs10244329 polymorphism in <jats:italic><jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content><\/jats:italic> gene (recessive genotype model, <jats:italic>p<\/jats:italic> value\u00a0=\u00a00.048). The trend toward statistically significant difference in genotype distribution for rs10244329 polymorphism was confirmed in the Serbian and Macedonian populations (<jats:italic>p<\/jats:italic> value\u00a0=\u00a00.07). Our data suggest that genetic variability in the <jats:italic><jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content><\/jats:italic> gene might be associated with male infertility warranting further confirmation and mechanistic investigations.<\/jats:p>","DOI":"10.1111\/andr.12295","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T20:52:46Z","timestamp":1478206366000},"page":"70-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility"],"prefix":"10.1111","volume":"5","author":[{"given":"A.","family":"Hod\u017ei\u0107","sequence":"first","affiliation":[{"name":"Clinical Institute of Medical Genetics University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ristanovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Zorn","sequence":"additional","affiliation":[{"name":"Andrology Unit Reproductive Unit Department of Obstetrics and Gynecology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tuli\u0107","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Maver","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical Genetics University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Novakovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Plaseska\u2010Karanfilska","sequence":"additional","affiliation":[{"name":"Research Centre for Genetic Engineering and Biotechnology \u201cGeorgi D. Efremov\u201d Macedonian Academy of Sciences and Arts Skopje Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Peterlin","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical Genetics University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2675-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666151209151550"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.05133"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.38"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00352-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv057"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/ror.0.0040048"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod60.2.216"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1669"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/168659"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.106.000125"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2007.00779.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2006.00754.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2003.00434.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gav025"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-15-0261"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.4.1066"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.06.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.3.1190"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1119"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0398-213"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1610211"},{"key":"e_1_2_8_25_1","volume-title":"WHO Laboratory Manual for the Examination of Human Semen and Semen\u2010Cervical Mucus Interaction","author":"World Health Organization","year":"1999"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.9.7842"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-15"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12295","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T09:44:19Z","timestamp":1694943859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,3]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/andr.12295"],"URL":"https:\/\/doi.org\/10.1111\/andr.12295","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,3]]},"assertion":[{"value":"2016-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}