{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:44:28Z","timestamp":1769589868794,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of the study was to evaluate reproductive outcomes in a cohort of infertile couples with severe and complete asthenozoospermia undergoing <jats:styled-content style=\"fixed-case\">TESA<\/jats:styled-content> (testicular sperm aspiration) with <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>. We conducted a retrospective study of 28 couples with complete or severe asthenozoospermia who underwent <jats:styled-content style=\"fixed-case\">TESA<\/jats:styled-content> between January 2010 and December 2015. We compared <jats:styled-content style=\"fixed-case\">TESA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> outcomes of these couples to ejaculate <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> outcomes of 40 couples with severe asthenozoospermia treated during the same time period at our institution. Couples with female factor infertility and\/or female aged \u226539 were excluded. Sperm retrieval rates and <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> outcomes [(<jats:styled-content style=\"fixed-case\">MII<\/jats:styled-content> oocytes, fertilization rate, good embryo rate (transferred and frozen), couples with embryo transfer (per cycle started), clinical pregnancy (per embryo transfer)] were recorded. Patients were grouped based on whether they had ejaculated (Ej\u2010group) or testicular (<jats:styled-content style=\"fixed-case\">TESA<\/jats:styled-content>\u2010group) spermatozoa used. Testicular sperm patients were further classified based on whether they had complete asthenozoospermia (0% total motility) (Tc\u2010group) or severe asthenozoospermia (\u22641% progressive motility) (Ts\u2010group). Mean (\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) male and female ages were 36\u00a0\u00b1\u00a06 and 32\u00a0\u00b1\u00a04, respectively. Sperm recovery by testicular sperm aspiration (<jats:styled-content style=\"fixed-case\">TESA<\/jats:styled-content>) was successful in 100% (28\/28) of the men. The overall clinical pregnancy rate (<jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>) per cycle started was 34% (23\/68) with a mean of 1.1\u00a0\u00b1\u00a00.4 embryos transferred per transfer. Fertilization rates were significantly lower in <jats:styled-content style=\"fixed-case\">TESA<\/jats:styled-content>\u2010group compared to Ej\u2010group (52% vs. 67%, respectively; <jats:italic>p\u00a0=\u00a0<\/jats:italic>0.001), while male age was significantly higher in <jats:styled-content style=\"fixed-case\">TESA<\/jats:styled-content>\u2010group compared to Ej\u2010group (34\u00a0\u00b1\u00a06 vs. 37\u00a0\u00b1\u00a06, respectively; <jats:italic>p\u00a0=\u00a0<\/jats:italic>0.03). Moreover, female age was significantly higher in Tc\u2010group compared to Ts\u2010group (30\u00a0\u00b1\u00a04 vs. 33\u00a0\u00b1\u00a03, respectively; <jats:italic>p\u00a0=\u00a0<\/jats:italic>0.0285). However, there were no significant difference in clinical pregnancy rate per embryo transfer in the Tc\u2010group, Ts\u2010group, and Ej\u2010group (50% vs. 45% vs. 57%, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.8219). The data suggest that testicular sperm\u2010<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> is no better than ejaculated sperm\u2010<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> in couples with severe or complete asthenozoospermia. Randomized, controlled trials comparing ejaculated vs. testicular spermatozoa are needed to assess the true benefit of <jats:styled-content style=\"fixed-case\">TESA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> in these couples.<\/jats:p>","DOI":"10.1111\/andr.12317","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T23:32:40Z","timestamp":1486769560000},"page":"226-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Testicular sperm aspiration (<scp>TESA<\/scp>) for infertile couples with severe or complete asthenozoospermia"],"prefix":"10.1111","volume":"5","author":[{"given":"A. H.","family":"Al\u2010Malki","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Alrabeeah","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mondou","sequence":"additional","affiliation":[{"name":"OVO Fertility Clinic Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Brochu\u2010Lafontaine","sequence":"additional","affiliation":[{"name":"OVO Fertility Clinic Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Phillips","sequence":"additional","affiliation":[{"name":"OVO Fertility Clinic Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zini","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery McGill University Montreal QC Canada"},{"name":"OVO Fertility Clinic Montreal QC 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