{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:44:31Z","timestamp":1791931471187,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IBSA International"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The standard <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> treatment is based on a 3\u00a0months period, after which both quantitative\/qualitative improvement of sperm parameters and increased pregnancy rate were reported. In this prospective clinical trial, for the first time, we studied (i) Sperm hyaluronic acid binding capacity after highly purified <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> (hp<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>) treatment; (ii) the effect after short\u2010term and standard treatment on this functional parameter. As secondary objective, we analyzed three <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s on <jats:italic><jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content><\/jats:italic>\u03b2 and <jats:italic><jats:styled-content style=\"fixed-case\">FSHR<\/jats:styled-content><\/jats:italic> genes to define their potential predictive value for responsiveness. From a total of 210 consecutive patients, 40 oligo\u2010 and\/or astheno\u2010 and\/or teratozoospermic patients fulfilled the inclusion criteria. Treatment consisted in hp<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> 75\u00a0IU\/L every other day for 3\u00a0months. To avoid potential biases derived from the lack of placebo, we analyzed each patient after 4\u20136\u00a0months of \u2018wash\u2010out\u2019 period. After <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> treatment, we observed a statistically significant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) improvement of the percentage of hyaluronic acid bound spermatozoa from basal to T1 (after 1\u00a0month) and to T3 (after 3\u00a0months). Importantly, these values returned to near\u2010baseline value after the wash\u2010out. The same results were detected for total motile sperm count after 3\u00a0months with return to baseline after wash\u2010out. Forty\u2010two percent of patients responded to the therapy with increasing hyaluronic acid binding capacity above the double of the Intraindividual Variation (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) while 24% of patients reached above the normal Sperm\u2010Hyaluronan Binding Assay (<jats:styled-content style=\"fixed-case\">HBA<\/jats:styled-content>) value. Further increase in \u2018responders\u2019 was observed at T3. The responsiveness to treatment resulted independent from <jats:italic><jats:styled-content style=\"fixed-case\">FSHR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content><\/jats:italic>\u03b2 polymorphisms. The significant positive effect on sperm maturity after 1\u00a0month opens novel therapeutic perspectives. In view of both the high cost and the relative invasiveness of treatment, the short protocol (1\u00a0month) could represent a viable <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> treatment option prior Assisted Reproductive Techniques since <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>, by acting on sperm maturation, increases the proportion of functionally competent cells.<\/jats:p>","DOI":"10.1111\/andr.12333","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T15:22:44Z","timestamp":1489591364000},"page":"414-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Short\u2010term <scp>FSH<\/scp> treatment and sperm maturation: a prospective study in idiopathic infertile men"],"prefix":"10.1111","volume":"5","author":[{"given":"E.","family":"Casamonti","sequence":"first","affiliation":[{"name":"Sexual Medicine and Andrology Unit Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vinci","sequence":"additional","affiliation":[{"name":"Sexual Medicine and Andrology Unit Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Serra","sequence":"additional","affiliation":[{"name":"Sexual Medicine and Andrology Unit Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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