{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:40:51Z","timestamp":1791582051902,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Summary<\/jats:title>\n \n The hypothesis that the assumption of a probiotic associated with a prebiotic (Flortec, Bracco; one sachet contains:\n Lactobacillus paracasei<\/jats:italic>\n B21060 5\u00a0\u00d7\u00a010\n 9<\/jats:sup>\n cells\u00a0+\u00a0arabinogalctan 1243\u00a0mg\u00a0+\u00a0oligo\u2010fructosaccharides 700\u00a0mg\u00a0+\u00a0\n l<\/jats:sc>\n \u2010glutamine 500\u00a0mg) could improve the quality and quantity of spermatozoa in idiopathic oligoasthenoteratospermia (\n iAOT<\/jats:styled-content>\n ) patients to a larger extent than a control substance (starch) was tested. Forty\u2010one patients with no chromosomal aberrations were randomized into two groups: 20 received Flortec, one sachet per day for 6\u00a0months, whereas 21 received the control substance. The following data were collected: clinical history, scrotal Doppler scans, Y microdeletion, karyotype and cystic fibrosis screens, follicle\u2010stimulating hormone (\n FSH<\/jats:styled-content>\n ), luteinizing hormone (\n LH<\/jats:styled-content>\n ), estradiol (E2), testosterone (T), and prolactin (\n PRL<\/jats:styled-content>\n ) levels, and two semen analyses. Both the Flortec and the starch groups underwent two semen analyses and one\n FSH<\/jats:styled-content>\n ,\n LH<\/jats:styled-content>\n , T, E2, and\n PRL<\/jats:styled-content>\n measurement in the blood, at the beginning of the study, and after 6\u00a0months. The comparisons were carried out using a non\u2010parametric (Wilcoxon signed rank) test. The side effects were assessed and compared using the chi\u2010squared test. Group 1 (Flortec) had their sperm count improved: volume of the ejaculate (median from 2.4 to 3.1\u00a0mL;\n p<\/jats:italic>\n \u00a0<\u00a00.01), sperm concentration (median: from 15.2\u00a0\u00d7\u00a010\n 6<\/jats:sup>\n \/mL to 28.3\u00a0\u00d7\u00a010\n 6<\/jats:sup>\n \/39\u00a0mL;\n p<\/jats:italic>\n \u00a0<\u00a00.01), progressive motility (median: from 16.2 to 42.0%;\n p<\/jats:italic>\n \u00a0<\u00a00.01), and the percentage of typical forms (median: from 7 to 16.3%;\n p<\/jats:italic>\n \u00a0<\u00a00.01); in addition, their\n FSH<\/jats:styled-content>\n ,\n LH<\/jats:styled-content>\n , and T levels improved (\n p<\/jats:italic>\n \u00a0<\u00a00.01), while those of E2 and\n PRL<\/jats:styled-content>\n did not. Group 2 (control substance) had no modification in 42 of the parameters studied. There were no side effects in either group. These data showed that Flortec constitutes a safe therapy for improving the volume of the ejaculate and the quality\/quantity of spermatozoa in\n iOAT<\/jats:styled-content>\n patients.\n <\/jats:p>","DOI":"10.1111\/andr.12336","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T19:29:32Z","timestamp":1488310172000},"page":"439-444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["The association of a probiotic with a prebiotic (Flortec, Bracco) to improve the quality\/quantity of spermatozoa in infertile patients with idiopathic oligoasthenoteratospermia: a pilot study"],"prefix":"10.1111","volume":"5","author":[{"given":"C.","family":"Maretti","sequence":"first","affiliation":[{"name":"Department of Andrology Centro Medico Cirm (affiliated with GynePro) Outpatient Clinic of Piacenza Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cavallini","sequence":"additional","affiliation":[{"name":"Department of Andrology GynePro Medical Group Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470773666"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2006.00123.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.107.067330"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2013.99"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp048"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.02.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.07.1991"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(02)00281-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem190"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2016.31.2.193"},{"key":"e_1_2_8_12_1","first-page":"CD007411","article-title":"Antioxidants for male subfertility","volume":"12","author":"Showell MG","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_13_1","first-page":"287","volume-title":"Farma\u2010Annuario, Nutraceutici","author":"Sirtori CR","year":"2011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2010.01402.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-60"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2016.05.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2015-0685"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12061"},{"key":"e_1_2_8_19_1","volume-title":"WHO Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:20:01Z","timestamp":1695021601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,28]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/andr.12336"],"URL":"https:\/\/doi.org\/10.1111\/andr.12336","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,28]]},"assertion":[{"value":"2016-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}