{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:45:45Z","timestamp":1791650745848,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wetenschappelijk Fonds Willy Gepts of the UZ Brussel"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Summary<\/jats:title>\n \n Deletions on the long arm of the Y chromosome are a well\u2010known cause of male infertility and it is generally accepted that deletions involving the\n AZF<\/jats:styled-content>\n b region are not compatible with sperm production. Here, we report on two patients for whom basic diagnostic tests showed a deletion of the\n AZF<\/jats:styled-content>\n b region. Unexpectedly, both patients had some residual sperm production. Subsequently, extension and additional analyses of the\n AZF<\/jats:styled-content>\n b region disclosed an aberrant deletion pattern. Therefore, these results emphasize the need for a detailed and powerful analysis of cases where first\u2010line Yq deletion tests reveal an\n AZF<\/jats:styled-content>\n b deletion. Moreover, our study clearly demonstrated that only a very careful selection of test markers will avoid the pitfall of a \u2018no further treatment possible\u2019 wrongful conclusion.\n <\/jats:p>","DOI":"10.1111\/andr.12350","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T15:46:59Z","timestamp":1491839219000},"page":"691-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Are\n AZF<\/scp>\n b deletions always incompatible with sperm production?"],"prefix":"10.1111","volume":"5","author":[{"given":"K.","family":"Stouffs","sequence":"first","affiliation":[{"name":"Center for Medical Genetics\/Research Center Reproduction and Genetics Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZ Brussel) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vloeberghs","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine\/Biology of the Testis Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZ Brussel) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gheldof","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics\/Research Center Reproduction and Genetics Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZ Brussel) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tournaye","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine\/Biology of the Testis Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZ Brussel) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Seneca","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics\/Research Center Reproduction and Genetics Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZ Brussel) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.048"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2013.00173.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq209"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.04.038"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.9.2267"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2004.00495.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.01.099"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh847"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.4.291"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.07.022"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:44:46Z","timestamp":1696481086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/andr.12350"],"URL":"https:\/\/doi.org\/10.1111\/andr.12350","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,10]]},"assertion":[{"value":"2016-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}