{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:34:28Z","timestamp":1790242468631,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006396","name":"Qazvin University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["687"],"award-info":[{"award-number":["687"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The methylenetetrahydrofolate reductase (<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>) gene codes a crucial enzyme which involve in folate metabolism. The effect of <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> gene polymorphisms on male fertility status is uncertain and controversial. We evaluated the effect of B vitamin family intake on total homocysteine content and semen parameters of men with <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> gene polymorphisms. <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> genotypes frequency and serum total homocysteine concentration were measured among 280 men with impaired spermatogenesis (asthenospermia, oligospermia, severe oligospermia and azoospermia) and 85 control participants. B vitamin family dietary intakes were assessed using a semi\u2010quantitative food\u2010frequency questionnaire. In addition, concentrations of vitamins B9 and B12 were evaluated in serum samples of some participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a060). We observed significantly higher frequency of <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotypes in C677T polymorphism among oligospermic, severe oligospermic and azoospermic men. <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> genotype of A1298C polymorphism was significantly higher only in azoospermic men. Also, we observed critical effect of vitamin B9 and B12 intake on decreasing of total homocysteine and improving of semen parameters among the men with T allele of <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> C677T polymorphism. Our investigation showed that sufficient consumption of vitamins B9 and B12 influences sperm parameters of men with different <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> polymorphisms, especially genotypes with T allele.<\/jats:p>","DOI":"10.1111\/andr.12351","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T14:29:15Z","timestamp":1493130555000},"page":"704-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effect of B9 and B12 vitamin intake on semen parameters and fertility of men with <i><scp>MTHFR<\/scp><\/i> polymorphisms"],"prefix":"10.1111","volume":"5","author":[{"given":"R.","family":"Najafipour","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Centre Qazvin University of Medical Sciences Qazvin 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