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The study was a single\u2010center, three\u2010phase cross\u2010over pharmacokinetic study of three single doses (12.5, 25, 50\u00a0mg) of testosterone cream administered in random sequence on different days with at least 2\u00a0days between doses to healthy eugonadal volunteers with endogenous testosterone suppressed by administration of nandrolone decanoate. Serum testosterone,<jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content>and estradiol concentrations were measured by liquid chromatograpy, mass spectrometry in extracts of serum taken before and for 16\u00a0h after administration of each of the three doses of testosterone cream to the scrotal skin. Testosterone administration onto the scrotal skin produced a swift (peak 1.9\u20132.8\u00a0h), dose\u2010dependent (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) increase in serum testosterone with the 25\u00a0mg dose maintaining physiological levels for 16\u00a0h. Serum<jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content>displayed a time\u2010 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), but not dose\u2010dependent, increase in concentration reaching a peak concentration of 1.2\u00a0ng\/mL (4.1\u00a0n<jats:sc>m<\/jats:sc>) at 4.9\u00a0h which was delayed by 2\u00a0h after peak serum testosterone. There were no significant changes in serum estradiol over time after testosterone administration. We conclude that testosterone administration to scrotal skin is well tolerated and produces dose\u2010dependent peak serum testosterone concentration with a much lower dose relative to the non\u2010scrotal transdermal route.<\/jats:p>","DOI":"10.1111\/andr.12357","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T11:09:41Z","timestamp":1490353781000},"page":"725-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pharmacokinetics of testosterone cream applied to scrotal skin"],"prefix":"10.1111","volume":"5","author":[{"given":"R.","family":"Iyer","sequence":"first","affiliation":[{"name":"Andrology Department Concord Hospital and ANZAC Research Institute University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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