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Via the modification of the hypothalamic\u2013pituitary\u2013gonadal axis hormones or by non\u2010hormonal mechanisms, drugs may directly and indirectly induce sexual dysfunction and spermatogenesis impairment and alteration of epididymal maturation. This systematic literature review summarizes existing data about the negative impact and associations of pharmacological treatments on male fertility (excluding cytotoxic drugs), with a view to making these data more readily available for medical staff. In most cases, these effects on spermatogenesis\/sperm maturation\/sexual function are reversible after the discontinuation of the drug. When a reprotoxic treatment cannot be stopped and\/or when the impact on semen parameters\/sperm\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    is potentially irreversible (Sulfasalazine Azathioprine, Mycophenolate mofetil and Methotrexate), the cryopreservation of spermatozoa before treatment must be proposed. Deleterious impacts on fertility of drugs with very good or good level of evidence (Testosterone, Sulfasalazine, Anabolic steroids, Cyproterone acetate, Opioids, Tramadol, GhRH analogues and Sartan) are developed.\n                  <\/jats:p>","DOI":"10.1111\/andr.12366","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T15:42:38Z","timestamp":1497627758000},"page":"640-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":273,"title":["The impact of drugs on male fertility: a review"],"prefix":"10.1111","volume":"5","author":[{"given":"M.","family":"Semet","sequence":"first","affiliation":[{"name":"Centre clinico\u2010biologique d'Assistance M\u00e9dicale \u00e0 la Procr\u00e9ation \u2013 CECOS Pole Femmes\u2010Parents\u2010Enfants AP\u2010HM La Conception Marseille 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