{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:55:45Z","timestamp":1790621745740,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Several intralesional therapeutic protocols have been proposed for the treatment of Peyronie's disease. Among all, hyaluronic acid (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>) and verapamil have been differently tested. We aimed to evaluate the efficacy of intralesional verapamil (<jats:styled-content style=\"fixed-case\">ILVI<\/jats:styled-content>) compared with intralesional <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> in patients with early onset of Peyronie's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). This is a multi\u2010centre prospective double\u2010arm, randomized, double\u2010blinded study comparing <jats:styled-content style=\"fixed-case\">ILVI<\/jats:styled-content> vs. intralesional <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> after 12\u2010weeks. Sexually active men, older than 18\u00a0years and affected by the acute phase of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were eligible for this study. Patients have been double\u2010blinded randomly divided into two groups (1\u00a0:\u00a01 ratio): Group A received intralesional treatment with Verapamil (10\u00a0mg in 5\u00a0mL of normal saline water) weekly for 12\u00a0weeks, while group B received intralesional treatment with HA (0.8% highly purified sodium salt HA 16\u00a0mg\/2\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>) weekly for 12\u00a0weeks. The primary efficacy outcome was the change from the baseline to the endpoint (12\u00a0weeks after therapy) for the penile curvature (degree). The secondary outcome was the change in the plaque size and in the International Index of erectile Function (<jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u20105) score. The difference between post\u2010 and pre\u2010treatment plaque size was \u22121.36\u00a0mm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0\u00b1\u00a01.27) for Group A and \u22121.80\u00a0mm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0\u00b1\u00a02.47) for Group B (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\u20105 increased of 1.46 points (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0\u00b1\u00a02.18) in Group A and 1.78 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0\u00b1\u00a02.48) in Group B (<jats:italic>p<\/jats:italic>\u2010value\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). No difference in penile curvature was observed in Group A, while in Group B the penile curvature decreased of 4.60\u00b0 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0\u00b1\u00a05.63) from the baseline (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and vs. Group A. According to <jats:styled-content style=\"fixed-case\">PGI<\/jats:styled-content>\u2010I results, we found significant difference as concerning patient global impression of improvement (<jats:styled-content style=\"fixed-case\">PGI<\/jats:styled-content>\u2010I) (4.0 vs. 2.0; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). This prospective, double\u2010arm, randomized, double\u2010blinded study comparing <jats:styled-content style=\"fixed-case\">ILVI<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> as intralesional therapy showed greater efficacy of <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> in terms of penile curvature and <jats:styled-content style=\"fixed-case\">PGI<\/jats:styled-content>\u2010I.<\/jats:p>","DOI":"10.1111\/andr.12368","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T12:25:49Z","timestamp":1500380749000},"page":"771-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Evaluation of intralesional injection of hyaluronic acid compared with verapamil in Peyronie's disease: preliminary results from a prospective, double\u2010blinded, randomized study"],"prefix":"10.1111","volume":"5","author":[{"given":"V.","family":"Favilla","sequence":"first","affiliation":[{"name":"Urology Section Department of Surgery University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-7353","authenticated-orcid":false,"given":"G. 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