{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:23:27Z","timestamp":1792167807366,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq INCT 573747\/2008\u20103"],"award-info":[{"award-number":["CNPq INCT 573747\/2008\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Testosterone is the main hormonal agent used for cross\u2010sex hormone therapy in female\u2010to\u2010male transgender persons. Our aim was to systematically review the literature concerning the effects of testosterone on body mass index (\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    ), blood pressure, hematocrit, hemoglobin, lipid profile, and liver enzymes in transgender men.\n                    <jats:styled-content style=\"fixed-case\">PUBMED<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                    were searched for studies published until March 2017. Studies were included if they reported interventions with any dose of testosterone and comparison of variables before and during treatment. Of 455 potentially eligible articles, 13 were reviewed. Study duration ranged from 6 to 60\u00a0months, sample size ranged from 12 to 97 patients, and the most common treatment was parenteral testosterone undecanoate 1000\u00a0mg\/12\u00a0weeks. Slight but significant increases in\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    were reported (from 1.3 to 11.4%). Three out of seven studies assessing the impact of different testosterone formulations on blood pressure detected modest increases or clinically irrelevant changes in this variable. In another study, however, two patients developed hypertension, which was resolved after cessation of testosterone therapy. Decreases in\n                    <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\n                    \u2010cholesterol and increases in\n                    <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                    \u2010cholesterol were consistently observed. Eight studies observed a relationship between testosterone and increased hemoglobin (range: 4.9\u201312.5%) and hematocrit (range: 4.4\u201317.6%), but discontinuation of androgen therapy was not necessary. In one study, two patients developed erythrocytosis (hematocrit &gt;52%) after 9 and 12\u00a0months of treatment. One study analyzing testosterone formulations observed smaller increases in hemoglobin and hematocrit with testosterone gel. Six studies assessing liver function showed slight or no changes. Overall, the quality of evidence was low, given the lack of randomized clinical\/controlled trials and the small sample sizes. In conclusion, exogenous testosterone administration to transgender men was associated with modest increases in\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    , hemoglobin\/hematocrit, and\n                    <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                    \u2010cholesterol, and with decreases in\n                    <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\n                    \u2010cholesterol. Long\u2010term studies are needed to assess the long\u2010term risks of testosterone therapy, particularly as they relate to cardiometabolic risks such as diabetes, dyslipidemia and the metabolic syndrome.\n                  <\/jats:p>","DOI":"10.1111\/andr.12382","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T17:36:40Z","timestamp":1500053800000},"page":"881-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":156,"title":["Effects of testosterone therapy on\n                    <scp>BMI<\/scp>\n                    , blood pressure, and laboratory profile of transgender men: a systematic review"],"prefix":"10.1111","volume":"5","author":[{"given":"I.","family":"Velho","sequence":"first","affiliation":[{"name":"Gynecological Endocrinology Unit Division of Endocrinology Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"},{"name":"Gender Identity Program Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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