{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:57:38Z","timestamp":1793674658242,"version":"4.5.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K24HD082231"],"award-info":[{"award-number":["K24HD082231"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>There is currently no effective medical therapy for men with infertility due to oligoasthenozoospermia. As men with abnormal sperm production have lower concentrations of 13\u2010<jats:italic>cis<\/jats:italic>\u2010retinoic acid in their testes, we hypothesized that men with infertility from oligoasthenozoospermia might have improved sperm counts when treated with isotretinoin (13\u2010<jats:italic>cis<\/jats:italic>\u2010retinoic acid). We conducted a single\u2010site, single\u2010arm, pilot study to determine the effect of therapy with isotretinoin on sperm indices in 19 infertile men with oligoasthenozoospermia. Subjects were men between 21 and 60\u00a0years of age with infertility for longer than 12\u00a0months associated with sperm concentrations below 15\u00a0million sperm\/mL. All men received isotretinoin 20\u00a0mg by mouth twice daily for 20\u00a0weeks. Subjects had semen analyses, physical examinations, and laboratory tests every 4\u00a0weeks during treatment. Nineteen men enrolled in the study. Median (25th, 75th) sperm concentration increased from 2.5 (0.1, 5.9) million\/mL at baseline to 3.8 (2.1, 13.0) million\/mL at the end of treatment (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006). No significant changes in sperm motility were observed. There was a trend toward improved sperm morphology (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.056). Six pregnancies (three spontaneous and three from intracytoplasmic sperm injection) and five births occurred during the study. Four of the births, including all three of the spontaneous pregnancies, were observed in men with improvements in sperm counts with isotretinoin therapy. Treatment was well tolerated. Isotretinoin therapy improves sperm production in some men with oligoasthenozoospermia. Additional studies of isotretinoin in men with infertility from oligoasthenozoospermia are warranted.<\/jats:p>","DOI":"10.1111\/andr.12420","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T06:32:39Z","timestamp":1507185159000},"page":"1115-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Isotretinoin administration improves sperm production in men with infertility from oligoasthenozoospermia: a pilot study"],"prefix":"10.1111","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7419-435X","authenticated-orcid":false,"given":"J. K.","family":"Amory","sequence":"first","affiliation":[{"name":"Department of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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