{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:13:18Z","timestamp":1772601198453,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571435, 81571499, 81200468"],"award-info":[{"award-number":["81571435, 81571499, 81200468"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20161413"],"award-info":[{"award-number":["20161413"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Epididymal lumen fluids are directly responsible for sperm maturation. However, very little is known about the molecular details of small molecule metabolites in the epididymal lumen fluids until now. Here we identified and compared the metabolic profiles of mouse caput and cauda epididymal lumen fluids using GC\u2010MS technique. Among 236 metabolites identified in caput and cauda epididymis, 36 were significantly enriched in caput epididymis while 18 were significantly enriched in cauda epididymis. Pathway analysis identified ascorbate and aldarate metabolism and beta\u2010alanine metabolism as most relevant pathways in caput and cauda epididymis, respectively. Ascorbate, dehydroascorbic acid and beta\u2010alanine associated with these two pathways were firstly reported in mouse epididymal lumen fluids and might play important roles in sperm maturation.<\/jats:p>","DOI":"10.1111\/andr.12434","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T20:06:16Z","timestamp":1512158776000},"page":"247-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The dynamic metabolomic changes throughout mouse epididymal lumen fluid potentially contribute to sperm maturation"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-0244","authenticated-orcid":false,"given":"S.\u2010G.","family":"Hu","sequence":"first","affiliation":[{"name":"Reproductive Medical Center Renji Hospital School of Medicine Shanghai Jiaotong University Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive 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