{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:01:14Z","timestamp":1773810074634,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>S\u202atudies have suggested an association between varicocele, hypogonadism, and elevated oxidative stress markers, but no other health risks have been associated with varicoceles. \u202c\u202c\u202c\u202cWe sought to determine the association between varicocele and incident medical comorbidities. \u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202c\u202cUsing the Truven Health MarketScan<jats:sup>\u00ae<\/jats:sup> claims database from 2001 to 2009, we identified 4459 men with varicoceles, and 100,066 controls based on ICD\u20109 and CPT codes, with an average follow\u2010up of 3.1 person years. Men with varicoceles were classified as symptomatic or asymptomatic based on co\u2010existing diagnoses. Men with medical comorbidities present before or within 1\u00a0year of index diagnosis were excluded. Metabolic and cardiovascular outcome variables were identified via ICD\u20109 codes. A Cox regression analysis was used to assess incident risk of metabolic and cardiovascular disease amongst the different groups. Men with varicoceles had a higher incidence of heart disease compared to men who underwent infertility testing (HR 1.22, 95% CI: 1.03\u20131.45), and men who underwent vasectomy (HR 1.32, 95% CI 1.13\u20131.54). The varicoceles group also had a higher risk of diabetes (HR 1.73, 95% CI: 1.37\u20132.18) and hyperlipidemia (HR 1.15, 95% CI: 1.03\u20131.28) compared to the vasectomy group. Furthermore, men with symptomatic varicoceles (<jats:italic>n<\/jats:italic>\u00a0=\u00a03442) had a higher risk of heart disease, diabetes, and hyperlipidemia following diagnosis, while men with asymptomatic varicoceles (<jats:italic>n<\/jats:italic>\u00a0=\u00a01017) did not. Given the prevalence of varicoceles, further research is needed to understand the implications of a varicocele to a man's overall health.<\/jats:p>","DOI":"10.1111\/andr.12437","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T20:07:18Z","timestamp":1512158838000},"page":"99-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The association between varicocoeles and vascular disease: an analysis of U.S. claims data"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0796-5625","authenticated-orcid":false,"given":"N. 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