{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:25:56Z","timestamp":1788348356342,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This study aimed to assess the effect of varicocelectomy and\/or mast cells (\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    s) stabilizer on sperm\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    fragmentation in infertile men with varicocele (Vx). Overall, 120 infertile patients were randomized to three equal treatment arms; patients that underwent varicocelectomy, patients on 1\u00a0mg ketotifen twice daily for three months, and patients that underwent varicocelectomy followed with 1\u00a0mg ketotifen twice daily for three months. These patients were subjected to history taking, clinical examination, semen analysis, and estimation of sperm\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    fragmentation index (\n                    <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>\n                    ). After 3\u00a0months, all investigated groups showed significant improvement regarding the mean total sperm count, sperm concentration, total sperm motility, and sperm normal forms percentage compared with the pre\u2010treatment data. As well, the mean sperm\n                    <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>\n                    was significantly improved compared with the pre\u2010treatment data; in men that underwent varicocelectomy (34.6% vs. 28.3%), in men on\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    stabilizer only (33.4% vs. 27.8%), and in men that underwent varicocelectomy followed by\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    stabilizer (34.3% vs. 25.1%). Sperm\n                    <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>\n                    improvement percentages showed the highest improvement in men that underwent varicocelectomy followed with\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    stabilizer compared with the other two groups (26.8% vs. 18.2%, 16.8%). Sperm\n                    <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>\n                    improvement percentages showed significant increases in the infertile patients with Vx grade\n                    <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                    compared to Vx grade\n                    <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                    in all investigated groups. It is concluded that in infertile men associated with Vx and high sperm\n                    <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>\n                    , surgical repair followed with\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    s stabilizer significantly improve sperm\n                    <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>\n                    compared with either surgical repair or\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    s stabilizer alone.\n                  <\/jats:p>","DOI":"10.1111\/andr.12445","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T15:05:55Z","timestamp":1512140755000},"page":"146-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Effect of varicocelectomy and\/or mast cells stabilizer on sperm\n                    <scp>DNA<\/scp>\n                    fragmentation in infertile patients with varicocele"],"prefix":"10.1111","volume":"6","author":[{"given":"A.","family":"Zaazaa","sequence":"first","affiliation":[{"name":"Department of Andrology, Sexology &amp; STIs Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Adel","sequence":"additional","affiliation":[{"name":"Department of Andrology, Sexology &amp; STIs Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Fahmy","sequence":"additional","affiliation":[{"name":"Department of Andrology, Sexology &amp; STIs Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Elkhiat","sequence":"additional","affiliation":[{"name":"Department of Andrology, Sexology &amp; STIs Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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