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This study addresses the impact of neonatal thymectomy on male \u200ereproductive function in pubertal and adult animals. Neonatal Sprague Dawley rats were allotted to four treatments consisting of fully thymectomized, partially thymectomized, intact, and sham\u2010operated rats. Half of the rats in each treatment were sacrificed at 40 and the other half at 80\u00a0days of age. Testicular volume, ventral prostate and spleen weight, several sperm attributes (concentration, motility, livability, membrane integrity, sperm penetration into mucus, total antioxidant capacity, mitochondrial dehydrogenase activity), plasma superoxide dismutase, glutathione, and testosterone level as well as fertility decreased in thymectomized rats. Adrenal gland weight, sperm malondialdehyde level, indices of oxidative stress, sperm abnormality, testicular and sperm lipid peroxidation, protein carbonylation, and sperm reactive oxygen species generation increased in thymectomized rats. In thymectomized rats, the testes contained high levels of malondialdehyde but low levels of glutathione and ferric\u2010reducing antioxidant power. Epididymal sperm reactive oxygen species, blood lipid peroxidation, and oxidative stress indices \u200e\u200ein blood and spermatozoa were highest in fully thymectomized, intermediate \u200ein partially thymectomized, and lowest in both pubertal and mature control rats. Blood levels of superoxide dismutase, lipid peroxidation indices, and \u200etestosterone, and mitochondrial adenosine triphosphate and \u200edehydrogenase activities in epididymal spermatozoa were lowest in fully thymectomized, \u200eintermediate in partially thymectomized, and highest in both pubertal and mature control rats.\u200e The data indicated that increased oxidative stress and mitochondrial dysfunction might play a role in the mechanism of immunosuppression\u2010induced testicular and sperm abnormalities.<\/jats:p>","DOI":"10.1111\/andr.12448","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T20:05:58Z","timestamp":1512158758000},"page":"199-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Retracted: Is immunosuppression, induced by neonatal thymectomy, compatible with poor reproductive performance in adult male rats?"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8283-6538","authenticated-orcid":false,"given":"M. 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