{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:15:38Z","timestamp":1770776138587,"version":"3.50.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In a case\u2010controlled study, we assessed the expressed seminal <jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>\u2010dependent protein deacetylase (<jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1) expression in infertile oligoasthenoteratozoospermic (<jats:styled-content style=\"fixed-case\">OAT<\/jats:styled-content>) men associated with varicocoele. Our study involved 81 men, recruited from the University hospitals, after ethical approval and informed consent. They were allocated into fertile normozoospermic men (<jats:italic>n<\/jats:italic>\u00a0=\u00a023), infertile <jats:styled-content style=\"fixed-case\">OAT<\/jats:styled-content> men without varicocoele (<jats:italic>n<\/jats:italic>\u00a0=\u00a023) and infertile <jats:styled-content style=\"fixed-case\">OAT<\/jats:styled-content> men with varicocoele (<jats:italic>n<\/jats:italic>\u00a0=\u00a035). Inclusion criteria consisted of confirmation of abnormal semen parameters and normal female partners whereas exclusion criteria were leukocytospermia, tobacco smoking, hormonal therapy, immunological disorders, dyslipidemia, hypogonadism, cardiovascular disorders, morbid obesity, and hepatic or renal failures. All participants had an interview to assess clinical history, clinical examination, semen analysis, and estimation of seminal <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 expression. Seminal SIRT1 expression was significantly lower in infertile <jats:styled-content style=\"fixed-case\">OAT<\/jats:styled-content> men than fertile men. Among infertile <jats:styled-content style=\"fixed-case\">OAT<\/jats:styled-content> men, seminal <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 expression was significantly lower in those with varicocoele than in those without. Additionally, seminal <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 expression was significantly lower in varicocoele grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> cases compared with other grades. Seminal <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 expression was positively correlated with sperm concentration (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.327, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), total sperm motility (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.532, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), and sperm normal forms (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.469, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Our results suggest that seminal <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 expression has a role of male infertility being significantly decreased in infertile <jats:styled-content style=\"fixed-case\">OAT<\/jats:styled-content> men in general and in infertile <jats:styled-content style=\"fixed-case\">OAT<\/jats:styled-content> men associated with varicocoele in particular.<\/jats:p>","DOI":"10.1111\/andr.12462","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T02:16:43Z","timestamp":1516673803000},"page":"301-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Seminal <scp>SIRT<\/scp>1 expression in infertile oligoasthenoteratozoospermic men with varicocoele"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-0662","authenticated-orcid":false,"given":"T.","family":"Mostafa","sequence":"first","affiliation":[{"name":"Andrology Sexology &amp; STIs Department Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Nabil","sequence":"additional","affiliation":[{"name":"Andrology Sexology &amp; STIs Department Faculty of Medicine Beni Suef University Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rashed","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Makeen","sequence":"additional","affiliation":[{"name":"General Surgery Department Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"El\u2010Kasas","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Mohamaed","sequence":"additional","affiliation":[{"name":"Andrology Sexology &amp; STIs Department Faculty of Medicine Beni Suef University Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.02.013"},{"key":"e_1_2_8_3_1","first-page":"IE01","article-title":"The impact of oxidative stress on testicular function and the role of antioxidants in improving it: a review","volume":"11","author":"Asadi N","year":"2017","journal-title":"J Clin Diagn 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