{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T21:13:23Z","timestamp":1774559603968,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T00:00:00Z","timestamp":1518825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>H2<jats:styled-content style=\"fixed-case\">BFWT<\/jats:styled-content> is one of the testis\u2010specific histones that plays a fundamental role in spermatogenesis, and single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in this gene may result in male infertility. This study aimed to investigate the association between \u22129C&gt;T and 368A&gt;G transitions of <jats:italic>H2<jats:styled-content style=\"fixed-case\">BFWT<\/jats:styled-content><\/jats:italic> gene and male infertility through a case\u2013control, meta\u2010analysis, and a bioinformatics approach. In this case\u2013control study, 490 subjects including 240 idiopathic infertile men and 250 healthy controls were included. The \u22129C&gt;T and 368A&gt;G <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s genotyping were performed by a <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> method. To find eligible studies for meta\u2010analysis, we searched valid scientific databases. The odds ratios with 95% confidence intervals were estimated to find the strength of these associations. Furthermore, the influences of two common transitions on the molecular features of <jats:italic>H2<jats:styled-content style=\"fixed-case\">BFWT<\/jats:styled-content><\/jats:italic> were assessed by in silico tools. Our case\u2013control data revealed that \u22129C&gt;T is not associated with male infertility. But, there was a significant association between 368A&gt;G and male infertility. In the meta\u2010analysis, five eligible studies were included. Our data revealed significant associations between \u22129C&gt;T, 368A&gt;G, and male infertility in overall and stratified analyses. Moreover, structural analysis showed that 368A&gt;G could affect the protein structure (<jats:styled-content style=\"fixed-case\">SNAP<\/jats:styled-content> prediction: non\u2010neutral, score: 42, expected accuracy: 71%; <jats:styled-content style=\"fixed-case\">SIFT<\/jats:styled-content> prediction: deleterious, score: \u22122.55), while \u22129C&gt;T may affect the binding nucleotide in the promoter region. Based on these findings, two aforementioned polymorphisms were associated with increased risk of male infertility. However, studies with larger sample size and different ethnicities are needed to obtain more accurate conclusions.<\/jats:p>","DOI":"10.1111\/andr.12464","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T06:26:47Z","timestamp":1518848807000},"page":"306-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between two common transitions of <i>H2<scp>BFWT<\/scp><\/i> gene and male infertility: a case\u2013control, meta, and structural analysis"],"prefix":"10.1111","volume":"6","author":[{"given":"M.","family":"Teimouri","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology Faculty of Basic Sciences University of Mazandaran Babolsar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Najaran","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Kashan University of Medical Sciences Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hosseinzadeh","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology Faculty of Basic Sciences University of Mazandaran Babolsar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8270-3276","authenticated-orcid":false,"given":"T.","family":"Mazoochi","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Kashan University of Medical Sciences Kashan 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