{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:58:15Z","timestamp":1740167895283,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T00:00:00Z","timestamp":1518912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dr. Werner Jackstaedt Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study aims to evaluate whether cancer treatments differ in infertile men compared to men who have undergone vasectomy and age\u2010matched controls. We analyzed subjects from the Truven Health MarketScan Claims database from 2001 to 2009. Infertile men were identified through diagnosis and treatment codes. Comparison groups included vasectomized men and an age\u2010matched cohort who were not infertile and had not undergone vasectomy. We considered cancer types previously associated with infertility that were diagnosed after the diagnosis of infertility. The treatment regimens were determined based on the presence of claims with <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> codes for chemotherapy (<jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>), radiation (<jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content>) or surgical treatment (<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>) for each entity in all study groups. Cases with multimodal treatments were also identified. As a result, <jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content> was similarly distributed among the infertile, vasectomized, and control groups. In contrast, <jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> treatment length was shorter in infertile men. The frequency of multimodal treatment (i.e., radiation and chemotherapy) was twofold lower in men with infertility compared to other men. By focusing on treatment patterns for each cancer type among these groups, the duration of <jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content> was shorter in infertile men diagnosed with <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> compared to controls. We conclude that Infertile men diagnosed with cancer and specific cancer types experience different treatment courses, with shorter <jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> and less combined <jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content> compared to fertile and vasectomized men. These differences could reflect differences in stage at presentation, biological behavior, or treatment responses in infertile men.<\/jats:p>","DOI":"10.1111\/andr.12472","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T01:23:07Z","timestamp":1519003387000},"page":"408-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Male infertility is associated with altered treatment course of men with cancer"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0861-3138","authenticated-orcid":false,"given":"O.","family":"Eminaga","sequence":"first","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford CA USA"},{"name":"Department of Urology University Hospital of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Urology and Dermatology Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. C.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Health Research and Policy Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24272"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.1.73"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05771"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.06.042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq163"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.06.025"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.11.080"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1242\/dev.122.6.1703","article-title":"Inhibition of testicular germ cell apoptosis and differentiation in mice\u00a0misexpressing Bcl\u20102 in spermatogonia","volume":"122","author":"Furuchi T","year":"1996","journal-title":"Development"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01490-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.1.265.265"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2014.00200.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2009.179"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7264.789"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802885"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09321"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19210"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.f.1895"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7183.559"},{"key":"e_1_2_9_21_1","first-page":"263","article-title":"Spermatogenesis in Hodgkin's lymphoma patients: a retrospective study of semen quality before and after different chemotherapy regimens","volume":"31","author":"Paoli D","year":"2016","journal-title":"Hum Reprod"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1014"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(95)03551-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.12.1152"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9592-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.562"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25075"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2001.tb03439.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0193"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:46:50Z","timestamp":1695473210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,18]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/andr.12472"],"URL":"https:\/\/doi.org\/10.1111\/andr.12472","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"type":"print","value":"2047-2919"},{"type":"electronic","value":"2047-2927"}],"subject":[],"published":{"date-parts":[[2018,2,18]]},"assertion":[{"value":"2017-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}