{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:15:35Z","timestamp":1760015735987,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T00:00:00Z","timestamp":1518912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Human sperm morphology has been described as an essential parameter for the diagnosis of male infertility and a prognostic indicator of natural or assisted pregnancies. Nevertheless, standard morphological assessment remains a subjective analysis and its impact on intracytoplasmic sperm injection (<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>) is also of limited value. The objective of this prospective cohort study was to investigate whether motile sperm organelle morphology examination (<jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content>) can improve semen analysis by better defining male infertility and providing a better prognosis for <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> up to a year later. Data were obtained from 483 patients undergoing conventional semen analysis from June 2015 to June 2017 in a private university\u2010affiliated in\u00a0vitro fertilization (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>) center. The correlation of <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> with seminal parameters was evaluated. One hundred and thirty patients underwent <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> up to a year later, and the correlation between <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> outcomes was established. Except for volume, all seminal parameters were positively correlated with <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> I+<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> was also distinct between World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) classification groups, with normozoospermic and oligoasthenoteratozoospermic presenting the higher and the lower proportion of <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> I+<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, respectively. <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> I+<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> was prognostic for fertilization rate, high\u2010quality cleavage\u2010stage embryos rate, and blastocyst rate. The normality cutoff value based on blastocyst rate was <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> I+<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2265 5.5%. <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> could be a useful tool for the diagnosis of infertility severity as it is correlated with sperm morphology, motility, and concentration. Men who had higher <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> I+<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> had better <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> outcomes. The future use of <jats:styled-content style=\"fixed-case\">MSOME<\/jats:styled-content> as a routine method for semen analysis may be a reliable form of assessing male infertility.<\/jats:p>","DOI":"10.1111\/andr.12473","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T01:23:18Z","timestamp":1519003398000},"page":"420-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sperm morphological normality under high magnification is correlated to male infertility and predicts embryo development"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7626-3585","authenticated-orcid":false,"given":"B. 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