{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:33:27Z","timestamp":1791891207025,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Semen quality is suggested to be a universal biomarker for future health. Previous studies have mostly been registry based excluding the possibility to address the importance of lifestyle, fertility status, health and socio\u2010economic status. We aimed to investigate whether the association between semen quality and subsequent risk of hospitalization could be explained by differences in occupation, education, fertility, cryptorchidism, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> or smoking; 1423 men with first semen sample at Fertility Clinic, Frederiksberg Hospital, Denmark, from 1977 to 2010 responded to a questionnaire in 2012 about current health, lifestyle, educational level and occupation. They were followed in the Danish National Patient Registry to first\u2010time hospitalizations using <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u20108 and <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010 classification. Data were analysed by Cox proportional hazard regression models to adjust for the possible confounding factors. We found a significant higher risk of being hospitalized with decreasing sperm concentrations (0\u201315 mill\/mL: <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>1.78, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>:1.51\u20132.09; 16\u201350 mill\/mL: <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.37 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.17\u20131.60; 51\u2013100 mill\/mL: <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>1.25 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.07\u20131.45). Same significant association of being hospitalized with decreasing total sperm counts was seen. The dose\u2013response increase in risk in hospitalization with decreasing sperm concentration and total sperm count remained constant after further individual adjustment for occupation, marital status, fertility, cryptorchidism, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> or smoking. The association between semen quality and subsequent morbidity was not explained by differences in lifestyle, behavioural or fertility status. We were unable to adjust for all possible confounders simultaneously due to limited sample size, and reverse causation is a possible explanation as information about education and lifestyle was obtained after semen analysis and hospitalizations occurred and may have changed as consequence of both. Semen quality may be a universal biomarker for future health not explained by lifestyle and socio\u2010economic status, but this needs to be addressed further in future studies.<\/jats:p>","DOI":"10.1111\/andr.12477","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T20:07:57Z","timestamp":1519675677000},"page":"428-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Semen quality associated with subsequent hospitalizations \u2013 Can the effect be explained by socio\u2010economic status and lifestyle factors?"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6250-7208","authenticated-orcid":false,"given":"T.","family":"Latif","sequence":"first","affiliation":[{"name":"Coordinating Research Centre Bispebjerg &amp; Frederiksberg Hospitals Frederiksberg Denmark"},{"name":"Department of Environmental Medicine Institute of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lindahl\u2010Jacobsen","sequence":"additional","affiliation":[{"name":"Danish Aging Research Centre Unit of Epidemiology, Biostatistics and Biodemography University of Southern Denmark Odense Denmark"},{"name":"Max\u2010Planck Odense Centre on the Biodemography of Aging University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mehlsen","sequence":"additional","affiliation":[{"name":"Coordinating Research Centre Bispebjerg &amp; Frederiksberg Hospitals Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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A.","family":"Holmboe","sequence":"additional","affiliation":[{"name":"University Department of Growth and Reproduction and International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC) Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Pors","sequence":"additional","affiliation":[{"name":"Coordinating Research Centre Bispebjerg &amp; Frederiksberg Hospitals Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Brinth","sequence":"additional","affiliation":[{"name":"Coordinating Research Centre Bispebjerg &amp; Frederiksberg Hospitals Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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