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Over the past 30\u00a0years, Sertoli cells have been upgraded from a simple scaffold\u2010like structural system to a dynamic functional system of intercellular support that delivers potent immunomodulatory and trophic factors. Since the discovery of new Sertoli cell secretory products, these cells have been utilized in experimental cell transplantation and co\u2010transplantation protocols aimed at treating both chronic inflammatory and degenerative disorders. For these reasons, this work reviews the application of both naked and microencapsulated Sertoli cells used in cell transplantation studies of several chronic or autoimmune diseases such as diabetes mellitus, Laron dwarfism, and Duchenne muscular dystrophy and in studies aimed at the prevention of skin allograft rejection.<\/jats:p>","DOI":"10.1111\/andr.12484","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T07:51:53Z","timestamp":1522396313000},"page":"385-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Sertoli cells for cell transplantation: pre\u2010clinical studies and future perspectives"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4445-164X","authenticated-orcid":false,"given":"G.","family":"Luca","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"},{"name":"Division of Medical Andrology and Endocrinology of Reproduction University of Perugia and Saint Mary Hospital Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Arato","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sorci","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"},{"name":"Inter\u2010University Institute of Myology (IIM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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