{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:30:33Z","timestamp":1778049033678,"version":"3.51.4"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Peyronie's disease (\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    ) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (\n                    <jats:styled-content style=\"fixed-case\">CCH<\/jats:styled-content>\n                    ) is the first licensed drug for the treatment of\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    and is indicated in patients with palpable plaque and curvature deformity of at least 30\u00b0 of curvature. However, only few monocentric studies are available in the current literature and this is the first national multicentric study focusing on this new treatment. In five Italian centres, 135 patients have completed the treatment with three injections of\n                    <jats:styled-content style=\"fixed-case\">CCH<\/jats:styled-content>\n                    using Ralph's shortened modified protocol. The protocol consisted of three intralesional injections of\n                    <jats:styled-content style=\"fixed-case\">CCH<\/jats:styled-content>\n                    (0.9\u00a0mg) given at 4\u2010weekly intervals in addiction to a combination of home modelling, stretching and a vacuum device on a daily basis. An improvement in the angle of curvature was recorded in 128\/135 patients (94.8%) by a mean (range) of 19.1 (0\u201340)\u00b0 or 42.9 (0\u201367)% from baseline (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). There was also a statistically significant improvement in all\n                    <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">PDQ<\/jats:styled-content>\n                    questionnaires subdomains (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001 in all subdomains). This prospective multicentric study confirms that the three\u2010injection protocol is effective enough to achieve a good result and to minimize the cost of the treatment.\n                  <\/jats:p>","DOI":"10.1111\/andr.12497","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T07:42:51Z","timestamp":1525678971000},"page":"564-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Collagenase clostridium histolyticum for the treatment of Peyronie's disease: a prospective Italian multicentric study"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-404X","authenticated-orcid":false,"given":"M.","family":"Capece","sequence":"first","affiliation":[{"name":"Dipartimento di Neuroscienze e Scienze Riproduttive ed Odontostomatologiche Universita degli Studi di Napoli Federico II Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cocci","sequence":"additional","affiliation":[{"name":"Department of Urology Azienda Ospedaliero Universitaria Careggi Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-7353","authenticated-orcid":false,"given":"G.","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Urology Universita degli Studi di Catania Scuola di Facolta di Medicina Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-4025","authenticated-orcid":false,"given":"G.","family":"Cito","sequence":"additional","affiliation":[{"name":"Department of Urology Azienda Ospedaliero Universitaria Careggi Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Giubilei","sequence":"additional","affiliation":[{"name":"Department of Urology Azienda USL Toscana centro Sede di Empoli Empoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Cacciamani","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Integrata Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Garaffa","sequence":"additional","affiliation":[{"name":"The Institute of Urology London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Falcone","sequence":"additional","affiliation":[{"name":"Department of Urology Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Timpano","sequence":"additional","affiliation":[{"name":"Department of Urology Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino Torino 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II Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ralph","sequence":"additional","affiliation":[{"name":"The Institute of Urology London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mirone","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze e Scienze Riproduttive ed Odontostomatologiche Universita degli Studi di Napoli Federico II Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Mondaini","sequence":"additional","affiliation":[{"name":"Department of Urology Ospedale Santa Maria Annunziata Bagno a Ripoli 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(2017).P. V. EAU Guidelines on Erectile Dysfunction Premature Ejaculation Penile Curvature and Priapism. Retrieved fromhttp:\/\/uroweb.org\/guideline\/male-sexual-dysfunction\/(Accessed 25\/11\/2017)."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13096"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.05.098"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.07.26"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T08:26:19Z","timestamp":1694247979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,7]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/andr.12497"],"URL":"https:\/\/doi.org\/10.1111\/andr.12497","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733183120.793574533","asserted-by":"object"}]},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,7]]},"assertion":[{"value":"2017-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}