{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T22:55:43Z","timestamp":1780872943087,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Some evidences have supported the link between benign prostatic hyperplasia (BPH)\/lower urinary tract symptoms (LUTS) and inflammation. In this study, we aimed to evaluate the association between prostatic inflammation (PI) and non\u2010alcoholic steatohepatitis (NASH) evaluated by a non\u2010invasive scores in a cohort of patients affected by BPH\/LUTS. Between January 2012 and January 2016, we conducted a prospective study in a single academic outpatient clinic on 132 consecutive patients who underwent surgery for lower urinary tract symptoms (LUTS) due to bladder outlet obstruction (BOO). A non\u2010invasive non\u2010alcoholic steatohepatitis score (<jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> score) was calculated, and <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> was evaluated through the Irani score. Patients with a <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> score\u00a0&gt;\u00a01.05 had an average larger prostate volume (55 vs. 45\u00a0cc, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), a greater waist circumference (103 vs. 93.5\u00a0cm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), and high values of blood glucose, triglycerides, insulin, and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> compared to patients without <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>; 36% of patients with an Irani score\u00a0\u2265\u00a04 had <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> compared to 16.1% of patients who had a <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> score\u00a0&lt;\u00a01.05 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). We found that non\u2010alcoholic steatohepatitis (<jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>\u00a0\u2265\u00a01.05) was an independent risk factor for Irani score \u22654 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.24; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and of prostate volume \u2265 40\u00a0cc (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 13.99; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). <jats:styled-content style=\"fixed-case\">LUTS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> can be closely related, underlying common triggers of induction. In particular, inflammation seems to be associated with both conditions and with prostate gland overgrowth. Early identification of this class of patients could play a key role in preventing complications related to disease progression.<\/jats:p>","DOI":"10.1111\/andr.12505","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T05:34:05Z","timestamp":1527917645000},"page":"737-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Benign prostatic hyperplasia and intraprostatic inflammation are associated with liver inflammation: it's time for prevention"],"prefix":"10.1111","volume":"6","author":[{"given":"S.","family":"Privitera","sequence":"first","affiliation":[{"name":"Urology Section Department of Surgery University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-7353","authenticated-orcid":false,"given":"G. I.","family":"Russo","sequence":"additional","affiliation":[{"name":"Urology Section Department of Surgery University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-2372","authenticated-orcid":false,"given":"S.","family":"La Vignera","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Condorelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Calogero","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cantiello","sequence":"additional","affiliation":[{"name":"Department of Urology University Magna Graecia of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Damiano","sequence":"additional","affiliation":[{"name":"Department of Urology University Magna Graecia of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Favilla","sequence":"additional","affiliation":[{"name":"Urology Section Department of Surgery University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cimino","sequence":"additional","affiliation":[{"name":"Urology Section Department of Surgery University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Morgia","sequence":"additional","affiliation":[{"name":"Urology Section Department of Surgery University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01858.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.02.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36966-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2016.168"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2016.04.001"},{"key":"e_1_2_8_7_1","first-page":"S90","article-title":"The cost of treating the 10 most prevalent diseases in men 50\u00a0years of age or older","volume":"12","author":"Fenter TC","year":"2006","journal-title":"Am J Manag Care"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12342"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2012.44"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12728"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.07.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500221"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64957-7"},{"key":"e_1_2_8_15_1","first-page":"873","article-title":"Non\u2010alcoholic fatty liver disease (NAFLD)\u2013a review","volume":"24","author":"Karim MF","year":"2015","journal-title":"Mymensingh Med J"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x04vm552xx"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2010.51.4.266"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12186"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002557"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50161"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1595"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e3283336f3f"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08317.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.029"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00238-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/13685538.2015.1062980"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12877"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1392-4"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23237"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-015-1736-8"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22122159"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14007"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2017.02.004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv304"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0051-3"},{"issue":"1","key":"e_1_2_8_37_1","first-page":"1","article-title":"Benign prostatic hyperplasia: epidemiology, economics and evaluation","volume":"22","author":"Vuichoud C","year":"2015","journal-title":"Can J Urol"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443313"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T04:54:43Z","timestamp":1694840083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/andr.12505"],"URL":"https:\/\/doi.org\/10.1111\/andr.12505","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"2018-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}