{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:45:44Z","timestamp":1792035944126,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Seminal cytokines were previously reported to adversely affect process of spermatogenesis and ultimately induce poor semen quality. However, association between both\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20106 and\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010\u03b1 and leukocytospermia was not yet settled. The aim of this study was to evaluate the association between leukocytospermia and levels of interleukin\u20106 (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20106) and tumor necrosis factor\u2010alpha (\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010\u03b1) in semen of infertile men. This cross\u2010sectional study included 100 age\u2010matched (\u226518\u201345\u00a0years.) men. Participants were divided into four groups with 25 patients in each group: Group (A) \u2013 infertile patients with leukocytospermia and normal other semen parameters; Group (B) \u2013 infertile patients with leukocytospermia and abnormal semen parameters; Group (C) \u2013 infertile patients with oligospermia and\/or asthenospermia and\/or teratospermia but with no leukocytospermia; Group (D) \u2013 fertile patients with normal semen parameters and without leukocytospermia. All patients were assessed by detailed medical, sexual, fertility history, and complete physical examination. Laboratory assessment included hormonal and semen analysis and assessment of\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20106 and\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010\u03b1 in semen plasma. There were significant differences among the study groups regarding total sperm count, sperm concentration, and progressive motility (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.05 for each). There was significant increase in semen\n                    <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>\n                    counts in groups A and B vs. groups C and D (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003). There were significant associations between increase levels of\n                    <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>\n                    s\u00a0\u2265\u00a05\/\n                    <jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>\n                    and decrease levels of total sperm count (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.023), sperm concentration (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001), and sperm progressive motility (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.02). There were significant upregulations in mean level of\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20106 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001) and mean level of\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010\u03b1 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003) in groups A and B vs. groups C and D. Overall, leukocytospermia is associated with reduction in sperm count, progressive motility and further upregulation of seminal\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20106 and\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    \u2010\u03b1. The effect of treatment of leukocytospermia on the level of seminal cytokines is important point of future research.\n                  <\/jats:p>","DOI":"10.1111\/andr.12513","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T03:10:13Z","timestamp":1530933013000},"page":"775-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Association between leukocytospermia and semen interleukin\u20106 and tumor necrosis factor\u2010alpha in infertile men"],"prefix":"10.1111","volume":"6","author":[{"given":"E. M.","family":"Eldamnhoury","sequence":"first","affiliation":[{"name":"Department of Urology Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A.","family":"Elatrash","sequence":"additional","affiliation":[{"name":"Department of Urology Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Rashwan","sequence":"additional","affiliation":[{"name":"Department of Urology Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-5952","authenticated-orcid":false,"given":"A. I.","family":"El\u2010Sakka","sequence":"additional","affiliation":[{"name":"Department of Urology Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-126"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0400-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.02.050"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12501"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.01.124"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.7.1476"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0425-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.03.29"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afju.2016.03.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2605.1997.00062.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2008.57"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2015.02.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138061"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-002-0269-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60587-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01373-13"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.11.009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.5.1257"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12188"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2005.00668.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD16090"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem281"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2012.01293.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.143285"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.4049\/jimmunol.159.8.3921","article-title":"Molecular regulation of IL\u20106 activation by asbestos in lung epithelial cells: role of reactive oxygen species","volume":"159","author":"Simeonova PP","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2614692"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57588-8"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:54:25Z","timestamp":1694825665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,6]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/andr.12513"],"URL":"https:\/\/doi.org\/10.1111\/andr.12513","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,6]]},"assertion":[{"value":"2018-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}