{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:21:41Z","timestamp":1790914901593,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671450"],"award-info":[{"award-number":["81671450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401194"],"award-info":[{"award-number":["81401194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Postradical prostatectomy erectile dysfunction (<jats:styled-content style=\"fixed-case\">pRP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) is a major health issue. There has been a shortage of an effective treatment method until now. In this study, a total of 48 adult male Sprague\u2010Dawley (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) rats were randomly equally divided into four groups, including group 1\u2014sham surgery with cavernous nerve exposure plus vehicle, group 2\u2014bilateral cavernous nerve injury (<jats:styled-content style=\"fixed-case\">BCNI<\/jats:styled-content>) plus vehicle, group 3\u2014<jats:styled-content style=\"fixed-case\">BCNI<\/jats:styled-content> plus adipose\u2010derived mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>s)\u2010derived exosomes (<jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>\u2010Exo), and group 4\u2014<jats:styled-content style=\"fixed-case\">BCNI<\/jats:styled-content> plus bone marrow\u2010derived mesenchymal stem cell (<jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s)\u2010derived exosomes (<jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>\u2010Exo). Twenty\u2010one days following surgery, erectile function was measured before tissue harvest. Histologic and Western blot analyses were then performed. Exosomes were capable of internalization into human umbilical vein endothelial cells (<jats:styled-content style=\"fixed-case\">HUVEC<\/jats:styled-content>) in\u00a0vitro and could be detected in the corpus cavernosum in\u00a0vivo. The <jats:styled-content style=\"fixed-case\">nNOS<\/jats:styled-content> expression in the penile dorsal nerves (<jats:styled-content style=\"fixed-case\">DN<\/jats:styled-content>) and major pelvic ganglion (<jats:styled-content style=\"fixed-case\">MPG<\/jats:styled-content>), protein level of neurofilament in the <jats:styled-content style=\"fixed-case\">DN<\/jats:styled-content>, endothelial markers <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>, alpha smooth muscle actin (\u03b1\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>), the ratio of smooth muscle to collagen content were obviously lower in <jats:styled-content style=\"fixed-case\">BCNI<\/jats:styled-content> group compared with the sham group, while <jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>\u2010Exo and <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>\u2010Exo groups resulted in significant restoration of the above histopathological changes. Moreover, <jats:styled-content style=\"fixed-case\">BCNI<\/jats:styled-content> treated with <jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>\u2010Exo or <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>\u2010Exo had significantly higher mean intracavernous pressure\/mean arterial pressure ratio compared with <jats:styled-content style=\"fixed-case\">BCNI<\/jats:styled-content> group. The results demonstrated that both <jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>\u2010Exo and <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>\u2010Exo treatment could significantly alleviate pathological changes and improve the erectile function in <jats:styled-content style=\"fixed-case\">BCNI<\/jats:styled-content>\u2010related rats. Exosomes derived from <jats:styled-content style=\"fixed-case\">ADSC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s may be a potential agent for <jats:styled-content style=\"fixed-case\">pRP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> treatment.<\/jats:p>","DOI":"10.1111\/andr.12519","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T07:04:54Z","timestamp":1531724694000},"page":"927-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Exosomes derived from mesenchymal stem cells exert therapeutic effect in a rat model of cavernous nerves injury"],"prefix":"10.1111","volume":"6","author":[{"given":"M.","family":"Li","sequence":"first","affiliation":[{"name":"Molecular Biology Laboratory of Andrology Center Peking University First Hospital Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Urology Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology First Hospital Affiliated to Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Li","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory of Andrology Center Peking University First Hospital Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Yang","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory of Andrology Center Peking University First Hospital Peking University Beijing 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