{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:49:48Z","timestamp":1772603388926,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Miscarriage and take\u2010home baby are the most important issues to patients with cryptozoospermia in receiving intracytoplasmic sperm injection (\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      ). The\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      usually use ejaculated or testicular sperm. Unfortunately, no synthesized evidence reported miscarriage and take\u2010home baby rate between the two sperm sources.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study aimed to compare the miscarriage and take\u2010home baby rate of\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      using testicular and ejaculated sperm in patient with cryptozoospermia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      We conducted meta\u2010analyses that were based on data from Cochrane library, Ovid, PubMed, ScienceDirect, Scopus, and Web of Science. The pooled analyses used risk ratio (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      ) in random\u2010effects model. Sensitivity analyses by subgrouping were completed to explore the associations between mean age and outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study identified 331 potential citations and included four cohort studies for qualitative and quantitative synthesis. The four studies involved 331 patients with 479\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      cycles. The results showed no significant difference in miscarriage between testicular sperm group and ejaculated sperm group (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      \u00a0=\u00a01.06, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.48\u20132.35,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.88). Yet, take\u2010home babies per embryo transfer in testicular sperm group (53\/226, 23.45%) was more than ejaculated sperm group (59\/429, 13.75%) (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      \u00a0=\u00a01.72, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.21\u20132.44,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.002). Similar results can be found in take\u2010home babies per\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      cycle (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      \u00a0=\u00a01.77, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.28\u20132.44,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.0005), especially in younger couple (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      \u00a0=\u00a01.93, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.11\u20133.34,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.02). No small study bias was detected in the analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      This study found that testicular sperm has more advantage for\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      in patients with cryptozoospermia, especially in younger couple. These findings may help guide us when deciding the optimal method of sperm harvest for men with cryptozoospermia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Comparing to ejaculated sperm, testicular sperm showed benefits for take\u2010home baby rate, but not for miscarriage in patients with cryptozoospermia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.12546","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T02:05:01Z","timestamp":1536717901000},"page":"882-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association of sperm source with miscarriage and take\u2010home baby after ICSI in cryptozoospermia: a meta\u2010analysis of testicular and ejaculated sperm"],"prefix":"10.1111","volume":"6","author":[{"given":"F.\u2010Y.","family":"Ku","sequence":"first","affiliation":[{"name":"Department of Urology Taipei Medical University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology Taipei Medical University Hospital Taipei Taiwan"},{"name":"Department of Education and Humanities in Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Department of Urology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010W.","family":"Hsiao","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8244-2846","authenticated-orcid":false,"given":"Y.\u2010N.","family":"Kang","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Medicine Department of Education Taipei Medical University Hospital Taipei 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