{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:25:54Z","timestamp":1788827154142,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:00:00Z","timestamp":1544140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2014_3185"],"award-info":[{"award-number":["2014_3185"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evaluation of male fertility includes standard semen analysis; however, there is uncertainty about the value of sperm parameters in predicting fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between semen parameters and fatherhood during a long\u2010time period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Semen parameters (total sperm count, concentration, motility, and morphology) and sperm <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation Index (<jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>) assessed on samples collected from 195 Norwegian men from the general population in 2001\/2002 were matched with information about fatherhood until 2015, obtained from the Medical Birth Register. The parameters were dichotomized as normal vs. abnormal according to the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> reference values from 1999 and 2010. Cut\u2010offs at 20% and 30% were used for <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among men who had no children before 2003, those with normal progressive sperm motility had more often become fathers (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> 1999, cut\u2010off \u226550%, adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.8, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.3\u20136.1 and <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> 2010, cut\u2010off \u226532%; <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 4.2, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u201315). Based on the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> 1999 reference value, men with normal sperm concentration (\u226520 \u00d7 10<jats:sup>6<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>) had more often become fathers (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 3.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u20138.6). Men with progressive sperm motility \u226550% and concentration \u226520 \u00d7 10<jats:sup>6<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> did more often achieve fatherhood (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 8.4, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.1\u201334). For <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content>, there was a borderline significance at cut\u2010off 20% in the group of men who had ever been fathers (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.7, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0\u20137.0 <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results indicate that sperm progressive motility, sperm concentration, and <jats:styled-content style=\"fixed-case\">DFI<\/jats:styled-content> are associated with fatherhood during a longer time period, with sperm motility being most consistent. Although the sample size is relatively small and our results should be replicated in larger studies, they may be of clinical relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Semen parameters may have a diagnostic value not only in a short time frame but also for predicting future fertility potential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12558","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T12:51:39Z","timestamp":1544187099000},"page":"76-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between semen parameters and chance of fatherhood \u2010 a long\u2010term follow\u2010up study"],"prefix":"10.1111","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-3839","authenticated-orcid":false,"given":"G.","family":"Malm","sequence":"first","affiliation":[{"name":"Molecular Reproductive Research Department of Translational Medicine Lund University Skane University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rylander","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-0785","authenticated-orcid":false,"given":"A.","family":"Giwercman","sequence":"additional","affiliation":[{"name":"Molecular Reproductive Research Department of Translational Medicine Lund University Skane University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-3393","authenticated-orcid":false,"given":"T. B.","family":"Haugen","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences OsloMet\u2013Oslo Metropolitan University Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev197"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10514-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del326"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.73"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.08.20"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009844109023"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.00995.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.05010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu305"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2007.00799.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.7.1562"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0427"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.08.024"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12381"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2009.64"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp027"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.503"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14647273.2013.807522"},{"key":"e_1_2_9_21_1","volume-title":"WHO Laboratory Manual for the Examination of Human Semen and Sperm\u2010Cervical Mucus Interaction","author":"World Health Organization","year":"1992"},{"key":"e_1_2_9_22_1","volume-title":"WHO Laboratory Manual for the Examination of Human Semen and Sperm\u2010Cervical Mucus Interaction","author":"World Health Organization","year":"1999"},{"key":"e_1_2_9_23_1","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2000.tb03284.x"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:00:27Z","timestamp":1694368827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,7]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/andr.12558"],"URL":"https:\/\/doi.org\/10.1111\/andr.12558","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,7]]},"assertion":[{"value":"2018-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}