{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:36:28Z","timestamp":1787790988885,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Traditional risk factors used to assess cardiovascular risk miss a significant population who are indeed at risk for future cardiac events. Erectile dysfunction (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) is an emerging marker for future cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>) and major adverse cardiovascular events (<jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>), especially in young and middle\u2010aged men with vasculogenic <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>. Cavernous arteries morphological alterations at penile colour doppler ultrasound (P\u2010<jats:styled-content style=\"fixed-case\">CDU<\/jats:styled-content>) are used to find a vasculogenic <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated the possible relationship between cavernous arteries morphological alterations at P\u2010<jats:styled-content style=\"fixed-case\">CDU<\/jats:styled-content> assessment and future <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We conducted a retrospective cohort study involving 300 <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> patients, aged 35\u201365\u00a0years (mean age 54.1\u00a0\u00b1\u00a07.1), with a follow\u2010up period of 10\u00a0years. Patients underwent vascular evaluation including P\u2010<jats:styled-content style=\"fixed-case\">CDU<\/jats:styled-content>, colour doppler ultrasound of the carotid and lower limbs arteries. At baseline data for glucose metabolism, lipid profile, hypertension and hormonal status were collected. During the follow\u2010up period, the occurrence of <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content> was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a strong association between cavernous arteries morphological alterations and <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> with a threefold increased risk of future <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content> in comparison to patients with healthy cavernous arteries (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 3.2, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.17\u20138.78). This association remained statistically significant after adjustment for <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> risk factors (age, glycaemia, total cholesterol, hypertension and smoke).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Morphological alterations of cavernous arteries are independently associated with an increased risk of future <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>. These data contribute to the formulation of the hypothesis that cavernous artery pathology at P\u2010<jats:styled-content style=\"fixed-case\">CDU<\/jats:styled-content> is related to <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12561","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T13:58:29Z","timestamp":1541685509000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Penile doppler ultrasound predicts cardiovascular events in men with erectile dysfunction"],"prefix":"10.1111","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3181-7617","authenticated-orcid":false,"given":"N.","family":"Caretta","sequence":"first","affiliation":[{"name":"Department of Medicine Section\u00a0of Endocrinology and Centre for Human Reproduction Pathology University of Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"De Rocco Ponce","sequence":"additional","affiliation":[{"name":"Department of Medicine Section\u00a0of Endocrinology and Centre for Human Reproduction Pathology University of Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Minicuci","sequence":"additional","affiliation":[{"name":"CNR Neuroscience Institute Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Palego","sequence":"additional","affiliation":[{"name":"Department of Medicine Section\u00a0of Endocrinology and Centre for Human Reproduction Pathology University of Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of Medicine Section\u00a0of Endocrinology and Centre for Human Reproduction Pathology University of Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garolla","sequence":"additional","affiliation":[{"name":"Department of Medicine Section\u00a0of Endocrinology and Centre for Human Reproduction Pathology University of Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-6570","authenticated-orcid":false,"given":"A.","family":"Ferlin","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences Endocrine and Metabolic Unit University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-2183","authenticated-orcid":false,"given":"C.","family":"Foresta","sequence":"additional","affiliation":[{"name":"Department of Medicine Section\u00a0of Endocrinology and Centre for Human Reproduction Pathology University of Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2018.02.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2003.tb02743.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901413"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01112.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2014.302148"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00982.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.024"},{"key":"e_1_2_9_9_1","first-page":"1","article-title":"Erectile dysfunction and risk of cardiovascular and all\u2010cause mortality in the general population: a meta\u2010analysis of cohort studies","volume":"3","author":"Fan Y","year":"2018","journal-title":"World J Urol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.08.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12342"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.041"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901477"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.2.213"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.440"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-015-0482-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2013.10.133"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4065\/84.2.108"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000877"},{"key":"e_1_2_9_20_1","first-page":"4","volume-title":"Atlas of Clinical Urology","author":"Lue TF","year":"1999"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.10.013"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01087.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X17725809"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12958"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.128413"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02474.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.08.038"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2017.12.027"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.3.251"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.23.2996"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033990"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043673"},{"key":"e_1_2_9_33_1","first-page":"1","article-title":"Does erectile dysfunction independently predict cardiovascular events? It's time to act on the evidence","volume":"1","author":"Zhao B","year":"2018","journal-title":"Eur J Prev Cardiol"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12561","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:00:03Z","timestamp":1694368803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/andr.12561"],"URL":"https:\/\/doi.org\/10.1111\/andr.12561","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,8]]},"assertion":[{"value":"2018-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}