{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:58:38Z","timestamp":1789052318087,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Premature ejaculation (PE<\/jats:styled-content>) is present in up to 30% of men with erectile dysfunction (ED<\/jats:styled-content>).<\/jats:p><\/jats:sec>Objectives<\/jats:title>To assess the clinical features of men complaining of both ED<\/jats:styled-content> and PE<\/jats:styled-content> (ED<\/jats:styled-content>\u2010PE<\/jats:styled-content>) as compared to men reporting only ED<\/jats:styled-content> or PE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>A consecutive series of 4024 men (mean age 51.2\u00a0\u00b1\u00a013.2\u00a0years) consulting for sexual dysfunction was studied. The population was categorized into ED<\/jats:styled-content>\u2010only (n<\/jats:italic>\u00a0=\u00a02767; 68.8%), PE<\/jats:styled-content>\u2010only (n<\/jats:italic>\u00a0=\u00a0475; 1.8%), and ED<\/jats:styled-content>\u2010PE<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a0782; 19.4%). Sexual symptoms were evaluated using the structured interviews SIEDY<\/jats:styled-content> and ANDROTEST<\/jats:styled-content>. Penile color Doppler ultrasound (PDCU<\/jats:styled-content>) parameters were also assessed.<\/jats:p><\/jats:sec>Results<\/jats:title>When compared to PE<\/jats:styled-content> alone, ED<\/jats:styled-content>\u2010PE<\/jats:styled-content> reported more sexual complaints, including impaired morning erections [OR<\/jats:styled-content>\u00a0=\u00a05.8 (4.1; 8.3)], decreased sexual desire [OR<\/jats:styled-content>\u00a0=\u00a02.6 (1.8; 3.7)], decreased ejaculate volume [OR<\/jats:styled-content>\u00a0=\u00a02.7 (1.8; 4.0)], and reduced frequency of sexual intercourse [OR<\/jats:styled-content>\u00a0=\u00a01.4 (1.0; 2.0)]. Conversely, ED<\/jats:styled-content>\u2010PE<\/jats:styled-content> and ED<\/jats:styled-content>\u2010only men had a similar prevalence of sexual symptoms. In ED<\/jats:styled-content>\u2010PE<\/jats:styled-content> men, the characteristics of ED<\/jats:styled-content> were similar to ED<\/jats:styled-content>\u2010only men, whereas the characteristics of PE<\/jats:styled-content> were milder than in PE<\/jats:styled-content>\u2010only men. ED<\/jats:styled-content>\u2010PE<\/jats:styled-content> men had a significantly higher prevalence of hypertension, diabetes, and cardiovascular (CV<\/jats:styled-content>) diseases [OR<\/jats:styled-content>\u00a0=\u00a01.8 (1.1; 3.0), 2.7 (1.3; 5.6) and 2.7 (1.1; 6.5), respectively] than PE<\/jats:styled-content>\u2010only subjects. Moreover, ED<\/jats:styled-content>\u2010PE<\/jats:styled-content> men showed worse dynamic peak systolic velocity at PDCU<\/jats:styled-content> [B<\/jats:italic>\u00a0=\u00a0\u221212.0 (\u221217.7; \u22126.2)] and a greater 10\u2010year estimated CV<\/jats:styled-content> risk [B<\/jats:italic>\u00a0=\u00a03.8 (2.5; 5.1)] than PE<\/jats:styled-content>\u2010only patients. Conversely, comorbidities and PDCU<\/jats:styled-content> parameters were similar in ED<\/jats:styled-content>\u2010PE<\/jats:styled-content> and ED<\/jats:styled-content>\u2010only men.<\/jats:p><\/jats:sec>Discussion<\/jats:title>The present results suggest that men reporting ED<\/jats:styled-content> and PE<\/jats:styled-content> should be considered as patients with ED<\/jats:styled-content>\u2010only, at least at first glance. Consequently, the diagnosis\u2014including the CV<\/jats:styled-content> risk stratification\u2014and treatment should be primarily focused on the erectile problem.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Erectile dysfunction\u2010PE<\/jats:styled-content> patients present several similarities with those consulting only for ED<\/jats:styled-content>, whereas their characteristics are different from PE<\/jats:styled-content>\u2010only men. In agreement with the guidelines, our results confirm that ED<\/jats:styled-content>\u2010PE<\/jats:styled-content> men might be considered (and managed) primarily as patients with ED<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12579","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T05:43:31Z","timestamp":1545025411000},"page":"163-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical characteristics of men complaining of premature ejaculation together with erectile dysfunction: a cross\u2010sectional study"],"prefix":"10.1111","volume":"7","author":[{"given":"G.","family":"Rastrelli","sequence":"first","affiliation":[{"name":"Sexual Medicine and Andrology Unit Department of Experimental Clinical and Biomedical Sciences \u2018Mario Serio\u2019 University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Sexual Medicine and Andrology Unit Department of Experimental Clinical and Biomedical Sciences \u2018Mario Serio\u2019 University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Corona","sequence":"additional","affiliation":[{"name":"Sexual Medicine and Andrology Unit Department of Experimental Clinical and Biomedical Sciences \u2018Mario Serio\u2019 University of Florence Florence Italy"},{"name":"Endocrinology Unit Medical Department Azienda Usl Bologna Maggiore\u2010Bellaria Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Vignozzi","sequence":"additional","affiliation":[{"name":"Sexual Medicine and Andrology Unit Department of Experimental Clinical and Biomedical Sciences \u2018Mario Serio\u2019 University of Florence Florence Italy"},{"name":"I.N.B.B. \u2013 Istituto Nazionale Biostrutture e Biosistemi Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3267-4221","authenticated-orcid":false,"given":"M.","family":"Maggi","sequence":"additional","affiliation":[{"name":"Sexual Medicine and Andrology Unit Department of Experimental Clinical and Biomedical Sciences \u2018Mario Serio\u2019 University of Florence Florence Italy"},{"name":"I.N.B.B. \u2013 Istituto Nazionale Biostrutture e Biosistemi Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01975.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12504"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12382"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12738"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.12.028"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2605.2002.00368.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.02.053"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00982.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01248.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01601.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01744.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2010.01059.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00262.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.110.010397"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02762.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.13041"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.112.490.917"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.07.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12180"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2016.11.002"},{"key":"e_1_2_9_22_1","article-title":"Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation","author":"Hatzimouratidis K","year":"2015","journal-title":"Eur Assoc Urol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.01.016"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02401.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12315"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901250"},{"key":"e_1_2_9_27_1","first-page":"266","article-title":"Clinical study of sildenafil in the treatment of premature ejaculation complicated by erectile dysfunction","volume":"9","author":"Li X","year":"2003","journal-title":"Zhonghua Nan Ke Xue"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2012.00031.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2016.02.001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2015.12.034"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01092.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06290.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02507.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02824.x"},{"key":"e_1_2_9_35_1","first-page":"393","article-title":"Evaluation of the global cardiovascular absolute risk: the Progetto CUORE individual score","volume":"40","author":"Palmieri L","year":"2004","journal-title":"Ann Ist Super Sanita"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901006"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.07.004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01820.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02947.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-015-9322-3"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2018.04.005"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000146566.24909.7d"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T05:34:21Z","timestamp":1694324061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,16]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/andr.12579"],"URL":"https:\/\/doi.org\/10.1111\/andr.12579","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,16]]},"assertion":[{"value":"2018-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}