{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:11:47Z","timestamp":1788837107888,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While the spermatotoxic properties of cancer treatments such as chemotherapy and radiation therapy are widely recognized, the effect of malignancy itself on male fertility is not clearly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether malignancy is associated with diminished semen quality prior to spermatotoxic treatment among sperm bankers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Retrospective database review of de\u2010identified records was obtained for all episodes of sperm banking performed at a cryobank from January 2004 to May 2017 for one of the following reasons: \u2018future use\u2019 (e.g., military deployment and gender reassignment); infertility; benign disease; and malignancy, further categorized as testicular, other genitourinary (<jats:styled-content style=\"fixed-case\">GU<\/jats:styled-content>), solid non\u2010<jats:styled-content style=\"fixed-case\">GU<\/jats:styled-content>, hematologic, or unspecified. Dependent variables of interest were ejaculatory volume, sperm concentration, % motility, and total motile sperm count (<jats:styled-content style=\"fixed-case\">TMSC<\/jats:styled-content>), as well as post\u2010thaw <jats:styled-content style=\"fixed-case\">TMSC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1558 patients met the inclusion criteria. Multivariable regression analysis on log\u2010transformed data controlling for age demonstrated decreased ejaculatory volume and sperm concentration, % motility, and <jats:styled-content style=\"fixed-case\">TMSC<\/jats:styled-content> in the infertility group as compared to the \u2018future use\u2019 group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Testicular cancer was associated with decreased sperm concentration, <jats:styled-content style=\"fixed-case\">TMSC<\/jats:styled-content>, and post\u2010thaw <jats:styled-content style=\"fixed-case\">TMSC<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001); other <jats:styled-content style=\"fixed-case\">GU<\/jats:styled-content> malignancy was associated with decreased ejaculatory volume (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Benign disease, solid non\u2010<jats:styled-content style=\"fixed-case\">GU<\/jats:styled-content> malignancy, hematologic malignancy, and unspecified malignancy were not associated with decreased parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In addition to sperm bankers with known fertility issues, sperm bankers with testicular and other <jats:styled-content style=\"fixed-case\">GU<\/jats:styled-content> malignancy had worse baseline semen parameters as compared to individuals pursuing banking for future use. These findings can inform patient counseling and consent prior to sperm banking and disease treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals with testicular and other <jats:styled-content style=\"fixed-case\">GU<\/jats:styled-content> malignancy who banked spermatozoa before undergoing spermatotoxic therapy demonstrated worse baseline semen parameters as compared to individuals banking spermatozoa for non\u2010medical reasons.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12602","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T20:59:29Z","timestamp":1550696369000},"page":"449-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genitourinary cancer patients have worse baseline semen parameters than healthy sperm bankers"],"prefix":"10.1111","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-7589","authenticated-orcid":false,"given":"R.","family":"Xu","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Centola","sequence":"additional","affiliation":[{"name":"New England Cryogenic Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tanrikut","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston MA USA"},{"name":"New England Cryogenic Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12610-016-0031-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.11.015"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12451"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.00956.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2003.11.024"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.08.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26221"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12037"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.031"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2013.145"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20170009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.08.022"},{"key":"e_1_2_6_14_1","first-page":"263","article-title":"Spermatogenesis in Hodgkin's lymphoma patients: a retrospective study of semen quality before and after different chemotherapy regimens","volume":"31","author":"Paoli D","year":"2016","journal-title":"Hum Reprod"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2016.05.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11229"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21185"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990815)86:4<697::AID-CNCR20>3.0.CO;2-J"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-013-0345-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.10.023"},{"key":"e_1_2_6_22_1","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T05:25:17Z","timestamp":1694323517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,20]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/andr.12602"],"URL":"https:\/\/doi.org\/10.1111\/andr.12602","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,20]]},"assertion":[{"value":"2018-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}