{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:55:45Z","timestamp":1790794545501,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571192"],"award-info":[{"award-number":["31571192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701119"],"award-info":[{"award-number":["31701119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Small non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (snc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) accomplish a huge variety of biological functions. Over the past decade, we have witnessed the substantial progress in the epididymal snc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> studies. In the Epididymis 7, we had the true privilege of having a whole session to share our findings and exchange ideas on the epididymal snc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This mini\u2010review attempts to provide an overview of what is known about the snc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in the mammalian epididymis and discuss the future directions in this field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We surveyed literature regarding the snc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> studies in the mammalian epididymis, and integrated some of our unpublished findings as well. We focus on the progress in methodology and the advances in our understanding of the expression and functions of epididymal snc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Discussion<\/jats:title><jats:p>The applications of high\u2010throughput approaches have made great contributions in the discovery of new snc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> species and profiling their dynamics in the epithelial cells, the passing spermatozoa, and the luminal environment. The diverse classes of epididymal snc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s exert important biological functions from the in situ regulation of epididymal gene expression to the epigenetic inheritance in the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although still in its infancy, we believe that the research on epididymal snc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s will not only lead to a better understanding of their physiological and pathological functions, but also contribute to the whole landscape of the <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> field.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12639","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T05:12:12Z","timestamp":1556773932000},"page":"681-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Epididymal small non\u2010coding <scp>RNA<\/scp> studies: progress over the past decade"],"prefix":"10.1111","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8084-0867","authenticated-orcid":false,"given":"C.","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Cancer Biology Dana\u2010Farber Cancer Institute Boston MA USA"},{"name":"Department of Genetics Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. L.","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular Andrology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular Andrology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology Dana\u2010Farber Cancer Institute Boston MA USA"},{"name":"Department of Genetics Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. 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