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Questionnaire data of 82 men with <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> and of 711 men without <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>A third of men with <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> considered their health poor, with more frequently diagnosed renal diseases, benign prostate hyperplasia, <jats:styled-content style=\"fixed-case\">STD<\/jats:styled-content>s, chronic nervous system diseases, and depression in them than in controls. They reported more cystitis and gynecological inflammations in their partners, and more prostatitis in their close relatives. This familial predisposition indicates possible genetic and immunologic background of <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> that may be associated also with susceptibility to respiratory tract infections revealed for the first time in our study. By the personality type, the men in the <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> group were less calm but more worrying. Hard drinks, antidepressants, sedative, and sleeping pills were more frequently consumed, and nightshift working and continuous stress were more commonly seen among men with than without <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> disturbed the sexual life as well as everyday activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The men with <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> are characterized by remarkable complex of co\u2010morbidities, habits, and attitudes. <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> possess substantial negative impact on quality of life. Successful work\u2010up of these patients needs multidimensional treatment modalities that take into consideration major factors of syndrome. Genetic factors and central nervous system imbalance but also partner's genital tract microbiota as the potential contributing and\/or perpetuating factors to <jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content> need more scientific attention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12647","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T09:45:27Z","timestamp":1557913527000},"page":"101-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dramatically deteriorated quality of life in men with prostatitis\u2010like symptoms"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9747-3618","authenticated-orcid":false,"given":"R.","family":"M\u00e4ndar","sequence":"first","affiliation":[{"name":"Department of Microbiology Institute of Biomedicine and Translational Medicine University of Tartu Tartu Estonia"},{"name":"Competence 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