{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:54:54Z","timestamp":1780404894956,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has been reported that paternal folic acid deficiency is correlated with male infertility and increased birth defects in the offspring. However, there are few data concerning the influence of folic acid supplementation on male\u2010factor infertility with<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>gene polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate whether folic acid supplementation has a beneficial effect on oligozoospermia with<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>gene polymorphisms in Chinese infertility population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The infertile men suffering oligozoospermia with<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>gene polymorphisms were randomly divided into the folic acid treatment groups receiving folic acid 0.8\u00a0mg daily for 3\u00a0months and the placebo groups receiving placebo for 3\u00a0months. Semen parameters, seminal<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>fragmentation were measured. Furthermore, spontaneous pregnancy rate and live birth rate were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Administration of folic acid for 3\u00a0months could significantly improve the seminal parameters in patients with<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>677<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>genotype in comparison with that receiving placebo. Moreover, seminal<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>and sperm<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>fragmentation index in patients with<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>677<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>genotype significantly declined at the end of treatment. Spontaneous pregnancy rate and live birth rate tended to be significantly higher in couples in which the men with<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>677<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>genotype receiving folic acid than that receiving placebo. However, folic acid treatment did not exhibit any advantage in<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>677<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>, 1298<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, 1298<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>, 1793<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>, or combined 677<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\/1298<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The anti\u2010oxidation function of folic acid is one of possible mechanisms invovled in improving seminal parameters and pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Folic acid supplementation has a beneficial effect on oligozoospermia with<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>677<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>genotype in term of seminal parameters, seminal<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>, sperm<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>fragmentation, and pregnancy outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12652","type":"journal-article","created":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T04:14:18Z","timestamp":1558757658000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of folic acid on oligozoospermia with<i><scp>MTHFR<\/scp><\/i>polymorphisms in term of seminal parameters,<scp>DNA<\/scp>fragmentation, and live birth rate: a double\u2010blind, randomized, placebo\u2010controlled 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