{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:32:05Z","timestamp":1788550325452,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIHR Biomedical Research Centre University College London Hospital"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and objectives<\/jats:title><jats:p>Adult undescended testicles (<jats:styled-content style=\"fixed-case\">UDT<\/jats:styled-content>s) often present to fertility specialists with subfertility or azoospermia and with either an intra\u2010abdominal or inguinal testicle(s). Performing an orchidopexy followed by a surgical sperm retrieval (<jats:styled-content style=\"fixed-case\">SSR<\/jats:styled-content>) is a potential option to retrieve spermatozoa. A microdissection <jats:styled-content style=\"fixed-case\">TESE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">mTESE<\/jats:styled-content>) procedure is performed to retrieve mature spermatozoa for use in <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>. This paper reviews the outcomes of <jats:styled-content style=\"fixed-case\">mTESE<\/jats:styled-content> in adults following an orchidopexy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A cohort of azoospermic patients underwent adult orchidopexy over a 10\u2010year period at a single specialist centre. Data were collected retrospectively from the patient records retrieved from an institutional database. All patients underwent pre\u2010operative imaging to localize the testicles, serum testosterone levels and a semen analysis. Separate intraoperative testicular biopsies were performed to exclude intratubular germ cell neoplasia (<jats:styled-content style=\"fixed-case\">ITGCN<\/jats:styled-content>) and to analyse the Johnsen score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients (age range 18\u201336\u00a0years) underwent orchidopexy procedures for either intra\u2010abdominal or inguinal testicles. Mean follow\u2010up was 34\u00a0months (range 13\u201358). Ninety per cent of patients had bilateral <jats:styled-content style=\"fixed-case\">UDT<\/jats:styled-content> with azoospermia. Pre\u2010operative testosterone levels were within the normal range (mean 13.9\u00a0nmol\/L; range 9.1\u201324.2). Five pelvic testicles (from four patients) were brought down and underwent a delayed <jats:styled-content style=\"fixed-case\">mTESE<\/jats:styled-content>. A total of nine inguinal orchidopexy procedures were carried out in eight men, and spermatozoa were found and preserved in three patients. None of the men with intra\u2010abdominal testicles had mature spermatozoa present following a delayed <jats:styled-content style=\"fixed-case\">mTESE<\/jats:styled-content>. Overall, <jats:styled-content style=\"fixed-case\">SSR<\/jats:styled-content> was successful in 37.5% of the patients. Histological analysis showed no cases of <jats:styled-content style=\"fixed-case\">ITGCN<\/jats:styled-content> and the Johnsen scores ranged from 1 to 3.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">Microdissection TESE<\/jats:styled-content> following orchidopexy for inguinal testicles can result in a successful <jats:styled-content style=\"fixed-case\">SSR<\/jats:styled-content> in over 1\/3rd of patients. Intra\u2010abdominal testicles appear to lack spermatogonia although the testicles can still be preserved for endogenous hormone production. Adult orchidopexy allows preservation of endogenous testosterone, easier self\u2010examination and an immediate or delayed <jats:styled-content style=\"fixed-case\">mTESE\u00a0in azoospermic patients<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12679","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T05:44:12Z","timestamp":1562823852000},"page":"166-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Microdissection\u00a0TESE (<scp>mTESE<\/scp>) following adult orchidopexy for undescended intra\u2010abdominal and inguinal testicles \u2013 surgical techniques and outcomes from a single\u2010centre cohort"],"prefix":"10.1111","volume":"8","author":[{"given":"P.","family":"Sangster","sequence":"first","affiliation":[{"name":"Institute of Andrology University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6364-0310","authenticated-orcid":false,"given":"H. M.","family":"Alnajjar","sequence":"additional","affiliation":[{"name":"Institute of Andrology University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Institute of Andrology University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Christodoulidou","sequence":"additional","affiliation":[{"name":"Institute of Andrology University College London Hospital London UK"},{"name":"Division of Surgery and Interventional Science University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Institute of Andrology University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Institute of Andrology University College London Hospital London UK"},{"name":"Division of Surgery and Interventional Science University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dawas","sequence":"additional","affiliation":[{"name":"Department of Surgery University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ralph","sequence":"additional","affiliation":[{"name":"Institute of Andrology University College London Hospital London UK"},{"name":"Division of Surgery and Interventional Science University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-1614","authenticated-orcid":false,"given":"A.","family":"Muneer","sequence":"additional","affiliation":[{"name":"Institute of Andrology University College London Hospital London UK"},{"name":"Division of Surgery and Interventional Science University College London London UK"},{"name":"NIHR Biomedical Research Centre University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15998-9"},{"key":"e_1_2_6_3_1","first-page":"289","article-title":"Incidence of undescended testis in the newborn","author":"Buemann B","year":"1961","journal-title":"Acta Chir Scand Suppl"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1991.tb15325.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1592197"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00560-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2000.00662.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06274-2"},{"key":"e_1_2_6_9_1","first-page":"6","article-title":"Importance of early postnatal germ cell maturation for fertility of cryptorchid males","volume":"55","author":"Hadziselimovic F","year":"2001","journal-title":"Horm Res"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.01.017"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)01006-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2007.01788.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067588"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2016.07.014"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.1.131"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.5296"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.20723"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000106100.21225.d7"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fandr.12679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12679","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T21:41:28Z","timestamp":1694209288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,10]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/andr.12679"],"URL":"https:\/\/doi.org\/10.1111\/andr.12679","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,10]]},"assertion":[{"value":"2018-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}