{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:30:56Z","timestamp":1790908256640,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["1762418"],"award-info":[{"award-number":["1762418"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/08450\u20103"],"award-info":[{"award-number":["2016\/08450\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/10100\u20100"],"award-info":[{"award-number":["2016\/10100\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Rheumatoid arthritis (\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      ) may reduce the testosterone production, thereby leading to testicular dysfunction and subfertility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study aimed to evaluate whether adjuvant\u2010induced arthritis (\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      ) induces histopathological and morphometric\u2010stereological alterations on testes with repercussions on the prostate, and alternatively, verifying\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      \u2010induced direct effects on the prostate, regardless of the testicular involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      Adult male\n                      <jats:italic>Wistar<\/jats:italic>\n                      rats were sham\u2010orchiectomized or orchiectomized. Twenty days after the surgery, these animals were injected with vehicle (\n                      <jats:styled-content style=\"fixed-case\">SHAM<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">ORQ<\/jats:styled-content>\n                      groups, respectively) or adjuvant (\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      ) to induce arthritis (\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">ORQ<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      groups, respectively). Forty days later, testes and ventral prostate were processed for histopathological and morphometric\u2010stereological analyses, as well as to\n                      <jats:styled-content style=\"fixed-case\">PCNA<\/jats:styled-content>\n                      immunohistochemistry. Collagen deposit was evaluated in prostate. Circulating testosterone levels were determined 15\u00a0days post\u2010\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      induction in\n                      <jats:styled-content style=\"fixed-case\">SHAM<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      rats and 40th day in all groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the testes,\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      promoted histopathological changes characterized by an increase in the percentage of abnormal tubules and reduction in the height of the seminiferous epithelium, daily production of spermatozoa, and cellular proliferation. In the prostate,\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      decreased the luminal volume of the secretory ducts. In condition of androgenic deprivation due to the orchiectomy,\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      induced proliferation of the prostatic epithelium.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      The effects of arthritis on testes and prostate were observed 40\u00a0days post\u2010\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      induction, possibly results of the hypoandrogenism were already established on 15th day post\u2010induction, which is related to the decline of the steroidogenesis in the Leydig cells. On the other hand, the joint inflammatory process may also have direct repercussions upon the prostate, regardless of this hypoandrogenism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      effects on reproductive tissues may be related to both hypoandrogenism and other direct inflammatory mechanisms. Possibly, these\n                      <jats:styled-content style=\"fixed-case\">AIA<\/jats:styled-content>\n                      effects on the testes and prostate occur at a stage in which the inflammatory process is most active, about 15\u201320\u00a0days after induction, remaining evident until the 40th day.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/andr.12693","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T02:19:45Z","timestamp":1567131585000},"page":"473-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adjuvant\u2010induced arthritis affects testes and ventral prostate of\n                    <i>Wistar<\/i>\n                    rats"],"prefix":"10.1111","volume":"8","author":[{"given":"C. R.","family":"Santos","sequence":"first","affiliation":[{"name":"Master's Program in Health and Aging Mar\u00edlia Medical School Mar\u00edlia SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. A.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Undergraduate Program in Medicine Mar\u00edlia Medical School Mar\u00edlia SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Chies","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology Mar\u00edlia Medical School Mar\u00edlia SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. F.","family":"Domeniconi","sequence":"additional","affiliation":[{"name":"Department of Anatomy Institute of Biosciences \u2010 UNESP Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. P.","family":"Zochio","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Biosciences \u2010 UNESP Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9843-0169","authenticated-orcid":false,"given":"M. A.","family":"Spadella","sequence":"additional","affiliation":[{"name":"Human Embryology Laboratory Mar\u00edlia Medical School Mar\u00edlia SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12280"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2002.tb02270.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/019262339902700125"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.02.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12436"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90722-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1992.tb01634.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00794"},{"key":"e_1_2_9_10_1","first-page":"443","article-title":"Reversible plasma testosterone levels reduction after gentamicin administration and Freund's Adjuvant Arthritic in Rats","volume":"49","author":"Carageorgiou HK","year":"2005","journal-title":"Indian J Physiol Pharmacol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441207"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.01.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1989.tb00130.x"},{"key":"e_1_2_9_14_1","first-page":"286","article-title":"Extra\u2010articular manifestations in rheumatoid arthritis","volume":"5","author":"Cojocaru M","year":"2010","journal-title":"Maedica"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12158"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.05.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.00972.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001958"},{"key":"e_1_2_9_19_1","first-page":"12","article-title":"Rheumatic diseases and male infertility","volume":"46","author":"Freire EAM","year":"2006","journal-title":"Rev Bras Reumatol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1676-24442011000500002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00503.2015"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22806"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.08.013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar328"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0838-2"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2006.01.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01886"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63834-5"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2005.07.009"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod43.6.1079"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.12.031"},{"key":"e_1_2_9_32_1","unstructured":"McKayAC&SharmaS. (2018)Anatomy Abdomen and Pelvis Seminal Vesicle. [Updated 2018 Dec 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan. Available at:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499854\/"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761991000700002"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22830"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042012000200002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2018.75523"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801875"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0540103"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2016.06.019"},{"key":"e_1_2_9_40_1","first-page":"544","volume-title":"Williams Tratado de Endocrinolog\u00eda","author":"Shalender B","year":"2010"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.46833\/reumatologiasp.2016.15.2.12-24","article-title":"Subfertilidade e infertilidade em pacientes com doen\u00e7as reumatol\u00f3gicas","volume":"15","author":"Silva CAA","year":"2016","journal-title":"Rev Paulista Reumatol"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.039"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2014.0595"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.148270"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39065"},{"key":"e_1_2_9_46_1","first-page":"49","article-title":"Influence of castration upon trophism and reactivity of rat seminal vesicles","volume":"15","author":"Valle RM","year":"1982","journal-title":"Braz J Med Biol Res"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20001101)45:3<253::AID-PROS8>3.0.CO;2-P"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.8.2839"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.30.1.23"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12693","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T02:24:57Z","timestamp":1693880697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,29]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/andr.12693"],"URL":"https:\/\/doi.org\/10.1111\/andr.12693","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,29]]},"assertion":[{"value":"2019-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}