{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:52:59Z","timestamp":1788457979065,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Andrology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Average paternal age in the United States has increased substantially in the last few decades. Children of advanced age fathers have a higher incidence of early onset cancer and neuropsychiatric disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To quantify the number of population adjusted cases of early\u2010onset cancer and neuropsychiatric disease in children attributable to increasing paternal age in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Paternal age in the United States from 1972 to 2015 was collected using the National Vital Statistics System (<jats:styled-content style=\"fixed-case\">NVSS<\/jats:styled-content>). Population attributable fraction and paternal age\u2010specific cumulative incidence rates of several cancers and neuropsychiatric disorders were obtained from peer\u2010reviewed publications. Paternal age\u2010specific birth rates were correlated with paternal age\u2010specific cumulative incidence rates to determine the number of attributable cases of disease caused by advancing age of fathers in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 2015 birth cohort in the United States is estimated to expect 9.2% more cases of acute lymphoblastic leukemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) diagnosed before 16\u00a0years of age (157 additional cases), 13.2% more cases of embryonal tumors in children &lt;5\u00a0years of age (209 additional cases), and 13.0% more cases of breast cancer in females younger than 40\u00a0years old (424 additional cases) compared to the 1972 birth cohort. We can estimate to expect 10.5% more cases of schizophrenia diagnosed before 21\u00a0years of age (2864 additional cases), 6.3% more cases of autism spectrum disorder (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) in adolescents &lt;17\u00a0years of age (2934 additional cases), 4.5% more cases of anorexia nervosa (<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>) in females 8\u201330\u00a0years old (620 additional cases), and 9.2% more cases of bipolar disorder in young patients 16\u201325\u00a0years old (252 additional cases) in the 2015 birth cohort compared to the 1972 birth cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increasing paternal age in the United States is associated with a substantial increase in the number of cases of early\u2010onset cancer and neuropsychiatric disease in offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/andr.12700","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T11:00:20Z","timestamp":1567508420000},"page":"342-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Disease burden in offspring is associated with changing paternal demographics in the United States"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-7414","authenticated-orcid":false,"given":"D. R.","family":"Greenberg","sequence":"first","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. S.","family":"Khandwala","sequence":"additional","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. K.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2000.tb01196.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.116.189241"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2010.07.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490070068044"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.4525"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2014.11.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20190"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.125"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.05.039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004458"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2016.1274791"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2014.10.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex267"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11396"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000771"},{"key":"e_1_2_9_17_1","first-page":"1","article-title":"Births in the United States, 2015","volume":"258","author":"Martin JA","year":"2016","journal-title":"NCHS Data Brief"},{"key":"e_1_2_9_18_1","first-page":"1","article-title":"Mean age of mothers is on the rise: United States, 2000\u20132014","volume":"232","author":"Mathews TJ","year":"2016","journal-title":"NCHS Data Brief"},{"key":"e_1_2_9_19_1","first-page":"1","article-title":"First births to older women continue to rise","volume":"152","author":"Matthews TJ","year":"2014","journal-title":"NCHS Data Brief"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.12.019"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10020252"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.03.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016747"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3469-0"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280210395740"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.05.046"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30677"}],"container-title":["Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/andr.12700","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T06:25:27Z","timestamp":1693895127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/andr.12700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/andr.12700"],"URL":"https:\/\/doi.org\/10.1111\/andr.12700","archive":["Portico"],"relation":{},"ISSN":["2047-2919","2047-2927"],"issn-type":[{"value":"2047-2919","type":"print"},{"value":"2047-2927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"assertion":[{"value":"2018-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}